[Leu15]-Gastrin I (human)
Based on 1 publication(s) in Google Scholar
[Leu15]-Gastrin I (human) is a Gastrin I, human (HY-P1097) peptide hormone derivative, which is trophic for normal gastrointestinal epithelium. Gastrin stimulates growth of gastric adenocarcinoma (gastric cancer) through G-protein-coupled receptor called the cholecystokinin (CCK) or cholecystokinin-B receptors (CCK-BR) that are overexpressed in this malignancy. [Leu15]-Gastrin I (human) is promising for research of gastric cancer.
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- 純度: 99.98%
- CAS 番号: 39024-57-2
- 分子式: C98H126N20O31
- 分子量:2080.16
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保管条件:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
![[Leu15]-Gastrin I (human) Chemical Structure](https://file.medchemexpress.com/product_pic/hy-p2671.gif "Click to View [Leu15]-Gastrin I (human) Chemical Structure")
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 [Leu15]-Gastrin I (human)
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生物活性
化学情報
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CAS 番号 39024-57-2
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性状 Solid
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分子量 2080.16
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分子式 C98H126N20O31
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Color White to off-white
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配列
{Pyr}-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2
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シーケンスの短縮
{Pyr}-GPWLEEEEEAYGWLDF-NH2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
溶剤 & 溶解度
DMSO : 100 mg/mL (48.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 10.53 mg/mL (5.06 mM; ultrasonic and adjust pH to 11 with NaOH)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[2]. Smith JP, et al. Gastrin and Gastric Cancer. Cell Mol Gastroenterol Hepatol. 2017 Mar 14;4(1):75-83. [Content Brief]
[3]. Barlos K, et al. Application of 2-chlorotrityl resin in solid phase synthesis of (Leu15)-gastrin I and unsulfated cholecystokinin octapeptide. Selective O-deprotection of tyrosine. Int J Pept Protein Res. 1991 Dec;38(6):555-61. [Content Brief]
[4]. Reubi JC, et al. Localization of cholecystokinin A and cholecystokinin B-gastrin receptors in the human stomach. Gastroenterology. 1997 Apr;112(4):1197-205. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 0.4807 mL | 2.4037 mL | 4.8073 mL | 12.0183 mL |
| 5 mM | 0.0961 mL | 0.4807 mL | 0.9615 mL | 2.4037 mL | |
| DMSO | 10 mM | 0.0481 mL | 0.2404 mL | 0.4807 mL | 1.2018 mL |
| 15 mM | 0.0320 mL | 0.1602 mL | 0.3205 mL | 0.8012 mL | |
| 20 mM | 0.0240 mL | 0.1202 mL | 0.2404 mL | 0.6009 mL | |
| 25 mM | 0.0192 mL | 0.0961 mL | 0.1923 mL | 0.4807 mL | |
| 30 mM | 0.0160 mL | 0.0801 mL | 0.1602 mL | 0.4006 mL | |
| 40 mM | 0.0120 mL | 0.0601 mL | 0.1202 mL | 0.3005 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
[Leu15]-Gastrin I (human) 関連分類
HY-P2671 関連分類
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