39024-57-2
![[Leu15]-Gastrin I (human) Chemical Structure](http://file.medchemexpress.cn/product_pic/hy-p2671.gif "[Leu15]-Gastrin I (human) Chemical Structure")
Chemical Structure
[Leu15]-Gastrin I (human)
- CAS No.: 39024-57-2
- Formula:C98H126N20O31
- Molecular Weight:2080.16
InChIKey: CMVMLPDUAGUTOC-FPBFVHJESA-N
SMILES: O=C([C@H]1N(CCC1)C(CNC([C@H]2NC(CC2)=O)=O)=O)N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@H](C(N)=O)CC3=CC=CC=C3)=O)=O)=O)CC4=CNC5=CC=CC=C45)=O)=O)CC6=CC=C(C=C6)O)=O)=O)=O)=O)=O)=O)=O)=O)CC7=CNC8=CC=CC=C78
Biological Activity: [Leu15]-Gastrin I (human) is a Gastrin I, human (HY-P1097) peptide hormone derivative, which is trophic for normal gastrointestinal epithelium. Gastrin stimulates growth of gastric adenocarcinoma (gastric cancer) through G-protein-coupled receptor called the cholecystokinin (CCK) or cholecystokinin-B receptors (CCK-BR) that are overexpressed in this malignancy. [Leu15]-Gastrin I (human) is promising for research of gastric cancer[1][2][3][4].
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[Leu15]-Gastrin I (human) | 99.98% | [Leu15]-Gastrin I (human) is a Gastrin I, human (HY-P1097) peptide hormone derivative, which is trophic for normal gastrointestinal epithelium. Gastrin stimulates growth of gastric adenocarcinoma (gastric cancer) through G-protein-coupled receptor called the cholecystokinin (CCK) or cholecystokinin-B receptors (CCK-BR) that are overexpressed in this malignancy. [Leu15]-Gastrin I (human) is promising for research of gastric cancer. | ||||||||||||||||||||
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- [1]. Kleomenis Barlos, et al. Veresterung von partiell geschützten peptid-fragmenten mit harzen. Einsatz von 2-chlortritylchlorid zur synthese von Leu15 -gastrin I[J]. Tetrahedron Letters, 1989.
- [2]. Smith JP, et al. Gastrin and Gastric Cancer. Cell Mol Gastroenterol Hepatol. 2017 Mar 14;4(1):75-83. [Content Brief]
- [3]. Barlos K, et al. Application of 2-chlorotrityl resin in solid phase synthesis of (Leu15)-gastrin I and unsulfated cholecystokinin octapeptide. Selective O-deprotection of tyrosine. Int J Pept Protein Res. 1991 Dec;38(6):555-61. [Content Brief]
- [4]. Reubi JC, et al. Localization of cholecystokinin A and cholecystokinin B-gastrin receptors in the human stomach. Gastroenterology. 1997 Apr;112(4):1197-205. [Content Brief]
Keywords
