BAM(8-22)
Based on 1 publication(s) in Google Scholar
BAM(8-22), a proteolytically cleaved product of proenkephalin A and sensory neuron-specific receptor (SNSR) agonist, is a potent activator of Mas-related G-protein-coupled receptors (Mrgprs), MrgprC11 and hMrgprX1. BAM(8-22) induces scratching in mice in an Mrgpr-dependent manner. In addition, BAM(8-22) has an analgesic effect and can also inhibit the activation of microglia.
For research use only. We do not sell to patients.
- Purity: 99.89%
- CAS No.: 412961-36-5
- Formula: C91H127N25O23S
- Molecular Weight:1971.20
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) BAM(8-22)
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Biological Activity
BAM(8 - 22) (intrathecal injection; 10 μL; 3-30 nmol; single dose) has an ameliorating effect in the rat pain model[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NMDA (HY-17551) treated adult (250-320 g) male Spraguee Dawley rats[3]
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Dosage:10 μL; 3, 10 and 30 nmol
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Administration:Intrathecal administration (i.t.); single dose
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Result:Dose-dependently diminished NMDA-evoked nocifensive behaviors and hyperalgesia.
Reduced NMDA-evoked expression of FLI and NADPH reactivity in the spinal dorsal horn.
Chemical Information
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CAS No. 412961-36-5
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Appearance Solid
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Molecular Weight 1971.20
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Formula C91H127N25O23S
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Color White to off-white
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Sequence
Val-Gly-Arg-Pro-Glu-Trp-Trp-Met-Asp-Tyr-Gln-Lys-Arg-Tyr-Gly
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Sequence Shortening
VGRPEWWMDYQKRYG
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Appl Biochem Biotechnol
Berbamine Attenuates Chronic Kidney Disease-Associated Pruritus by Targeting MRGPRX1/MrgprC11 Signaling. [Abstract]2025 Dec 26. PMID: 41452414
Solvent & Solubility
H2O : 100 mg/mL (50.73 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (50.73 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Wang A, et al. A Novel Mechanism of BAM8-22 Inhibiting Microglia Activation: Represses CX3CR1 Expression via Upregulating miR-184. J Mol Neurosci. 2020 Apr;70(4):550-558. [Content Brief]
[2]. Liu Q, et al. Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus. Cell. 2009 Dec 24;139(7):1353-65. [Content Brief]
[3]. Chen T, et al. Modulation of NMDA receptors by intrathecal administration of the sensory neuron-specific receptor agonist BAM8-22. Neuropharmacology. 2008 Apr;54(5):796-803. [Content Brief]
[4]. Parul Sikand, et al. BAM8-22 peptide produces itch and nociceptive sensations in humans independent of histamine release. J Neurosci. 2011 May 18;31(20):7563-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.5073 mL | 2.5365 mL | 5.0731 mL | 12.6826 mL |
| 5 mM | 0.1015 mL | 0.5073 mL | 1.0146 mL | 2.5365 mL | |
| 10 mM | 0.0507 mL | 0.2537 mL | 0.5073 mL | 1.2683 mL | |
| 15 mM | 0.0338 mL | 0.1691 mL | 0.3382 mL | 0.8455 mL | |
| 20 mM | 0.0254 mL | 0.1268 mL | 0.2537 mL | 0.6341 mL | |
| 25 mM | 0.0203 mL | 0.1015 mL | 0.2029 mL | 0.5073 mL | |
| 30 mM | 0.0169 mL | 0.0846 mL | 0.1691 mL | 0.4228 mL | |
| 40 mM | 0.0127 mL | 0.0634 mL | 0.1268 mL | 0.3171 mL | |
| 50 mM | 0.0101 mL | 0.0507 mL | 0.1015 mL | 0.2537 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
BAM(8-22) Related Classifications
HY-P1241 Related Classifications
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