1. GPCR/G Protein Neuronal Signaling
  2. Cholecystokinin Receptor
  3. Tarazepide

Tarazepide is a potent and specific CCK-A receptor antagonist.

For research use only. We do not sell to patients.

Tarazepide Chemical Structure

Tarazepide Chemical Structure

CAS No. : 141374-81-4

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Description

Tarazepide is a potent and specific CCK-A receptor antagonist.

IC50 & Target

CCK-A receptor[1]

In Vivo

Tarazepide decreases duodenal electric activity, reduces interdigestive pancreatic secretion, especially protein; reduces cephalic and early postprandial (milk) induced secretion of bicarbonate and protein.Pancreatic protein secretion to intravenous CCK-8 was little affected by atropine, but was significantly reduced by Tarazepide±Atropine; in contrast, protein secretion to intraduodenal CCK-8 was abolished by Tarazepide or atropine[1]. Leptin is administered to the animals at doses of 0.1, 1.0 or 10.0 μg/kg i.d. Tarazepide (2.5 mg/kg, i.d.), a CCK(1) receptor antagonist, is given to the rats prior to the application of leptin. CCK plasma level is measured by radioimmunoassay (RIA) following administration of leptin to the rats. Intraduodenal administration of leptin (1.0 or 10.0 microg/kg) to the fasted rats significantly and dose-dependently increases pancreatic protein and amylase outputs. Pancreatic secretory responses to leptin were totally abolished by prior capsaicin deactivation of sensory nerves or by pretreatment of the rats with Tarazepide[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

448.52

Formula

C28H24N4O2

CAS No.
SMILES

O=C(C1=CC2=CC=CC3=C2N1CCC3)N[C@@H]4C(N(C)C5=CC=CC=C5C(C6=CC=CC=C6)=N4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
Animal Administration
[1]

Calve[1]
The 5 to 7-day-old Friesian male calves (42.0±1.5 kg body weight) are used. The study is made on four calves. After recording 2 to 3 preprandial (interdigestive) MMC/PPS cycles, Tarazepide suspension (0.05, 0.5 and 5.0 mg/kg body weight), or vehicle alone (1% methylcellulose) is infused intraduodenally (i.d.).

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Tarazepide Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Tarazepide
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HY-U00062
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