Cholecystokinin-33 (swine)

Cat. No.: HY-P3652: FAQs
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Cholecystokinin-33 (swine) is a cholecystokinin (CCK) fragment. Cholecystokinin-33 (swine) can reduce food intake and gallbladder contraction.

For research use only. We do not sell to patients.

Cholecystokinin-33 (swine) Chemical Structure

CAS No. : 67256-27-3

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Description

Cholecystokinin-33 (swine) is a cholecystokinin (CCK) fragment. Cholecystokinin-33 (swine) can reduce food intake and gallbladder contraction^[1].

In Vivo

Cholecystokinin-33 (swine, 0.05-0.25 nM/kg; catheterization, for a branch of the abdominal aorta and a branch of the aorta located caudal) has gastrointestinal site specificity in regulating feeding behaviors in male rats. Cholecystokinin-33 swine reduces meal size and increased the satiety ratio at sites supplied by the cranial mesenteric artery^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague Dawley rats (400-450 g)^[1]
Dosage:	0.05, 0.15, and 0.25 nM/kg
Administration:	Catheterization, for a branch of the abdominal aorta and a branch of the aorta located caudal
Result:	Reduced meal size (MS) and increased the satiety ratio (SR).

Molecular Weight

3918.42

Formula

C₁₆₆H₂₆₂N₅₀O₅₂S₄

CAS No.

67256-27-3

Sequence

Lys-Ala-Pro-Ser-Gly-Arg-Val-Ser-Met-Ile-Lys-Asn-Leu-Gln-Ser-Leu-Asp-Pro-Ser-His-Arg-Ile-Ser-Asp-Arg-Asp-{Tyr-SO3H}-Met-Gly-Trp-Met-Asp-Phe-NH2

Sequence Shortening

KAPSGRVSMIKNLQSLDPSHRISDRD-{Tyr-SO3H}-MGWMDF-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Washington MC, et, al. Cholecystokinin-33, but not cholecystokinin-8 shows gastrointestinal site specificity in regulating feeding behaviors in male rats. Horm Behav. 2016 Sep;85:36-42. [Content Brief]

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cholecystokinin-33 (swine)67256-27-3Otherscholecystokininfood intakegallbladder contractionmeal sizesatiety ratioInhibitorinhibitorinhibit

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Cholecystokinin-33 (swine)