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LHX5 - LIM homeobox 5 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 64211

About LHX5

Cytogenetic location: 12q24.13 Genomic coordinates (GRCh38): 12:113,462,033-113,471,871 (from NCBI)

This gene has 2 transcripts (splice variants), 128 orthologues and 20 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be involved in the control of differentiation and development of the forebrain. In mice, this protein is essential for the regulation of precursor cell proliferation and the control of neuronal differentiation and migration during hippocampal development. This protein is involved in learning and motor functions in adult mice. [provided by RefSeq, Jul 2008]

LHX5 Products (1)

mRNA	Protein	Name
NM_022363.3	NP_071758.1	LIM/homeobox protein Lhx5

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LHX5 Protein Structure

LIM

Homeobox

0
100
200
300
402 a.a.

Protein Preferred Names	Protein Names
LIM/homeobox protein Lhx5	LIM homeobox protein 5

LHX5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LHX5	Q9H2C1	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	LHX5	Q9H2C1	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	LHX5	Q9H2C1	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	LHX5	Q9H2C1	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	LHX5	Q9H2C1	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	LHX5	Q9H2C1	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	LHX5	Q9H2C1	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	LHX5	Q9H2C1	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	LHX5	Q9H2C1	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	LHX5	Q9H2C1	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	LHX5	Q9H2C1	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	LHX5	Q9H2C1	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	LHX5	Q9H2C1	KAT5	Homo sapiens	Q92993	Validated Y2H	32814053
Intra	LHX5	Q9H2C1	KAT5	Homo sapiens	Q92993	Y2H Pooling	32814053
Intra	LHX5	Q9H2C1	KAT5	Homo sapiens	Q92993	Y2H Array	32814053
Intra	LHX5	Q9H2C1	HIP1	Homo sapiens	O00291	Y2H Array	32814053
Intra	LHX5	Q9H2C1	HIP1	Homo sapiens	O00291	Y2H Pooling	32814053
Intra	LHX5	Q9H2C1	HIP1	Homo sapiens	O00291	Validated Y2H	32814053
Intra	LHX5	Q9H2C1	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	LHX5	Q9H2C1	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	LHX5	Q9H2C1	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	LHX5	Q9H2C1	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	LHX5	Q9H2C1	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	LHX5	Q9H2C1	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	LHX5	Q9H2C1	COQ8A	Homo sapiens	Q8NI60	Validated Y2H	32814053
Intra	LHX5	Q9H2C1	COQ8A	Homo sapiens	Q8NI60	Y2H Pooling	32814053
Intra	LHX5	Q9H2C1	COQ8A	Homo sapiens	Q8NI60	Y2H Array	32814053
Intra	LHX5	Q9H2C1	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053
Intra	LHX5	Q9H2C1	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	LHX5	Q9H2C1	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Bestiality	Zoophilia
Scapuloperoneal Spinal Muscular Atrophy	SPSMA Amyotrophy, Neurogenic Scapuloperoneal, New England Type Neurogenic Scapuloperoneal Amyotrophy, New England Type Scapuloperoneal Neuronopathy Spinal Muscular Atrophy, Scapuloperoneal Amyotrophy Neurogenic Scapuloperoneal New England Type Muscular Atrophy, Spinal Scapuloperoneal Form Of Spinal Muscular Atrophy
Scapuloperoneal Myopathy
Kluver-Bucy Syndrome	Bilateral Temporal Lobe Disorder Klüver-Bucy Syndrome Klver-Bucy Syndrome Kluver Bucy Syndrome Memory Loss, Extreme Sexual Behavior, Placidity, And Visual Distractibility Post-Encephalitic Kluver Bucy Syndrome Post-Traumatic Kluver Bucy Syndrome
Developmental And Epileptic Encephalopathy 28	DEE28 Epileptic Encephalopathy, Early Infantile, 28 Eiee28 Developmental And Epileptic Encephalopathy, 28 Early Infantile Epileptic Encephalopathy 28 Encephalopathy, Epileptic, Early Infantile, Type 28

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07635	LHX5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20764	Lhx5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27278	Lhx5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	LHX5	VGNC	VGNC:30875
Mus musculus	LHX5	MGD	MGI:107792
Canis familiaris	LHX5	VGNC	VGNC:42666
Felis catus	LHX5	VGNC	VGNC:80449
Rattus norvegicus	LHX5	RGD	RGD:71079
Others	LHX5	NCBI