1. GPCR/G Protein
    Neuronal Signaling
  2. Cholecystokinin Receptor
  3. Devazepide

Devazepide (Synonyms: L-364,718; MK-329)

Cat. No.: HY-106301
Handling Instructions

Devazepide (L-364,718) is a potent, competitive, selective and orally active nonpeptide antagonist of cholecystokinin (CCK) receptor, with IC50s of 81 pM, 45 pM and 245 nM for rat pancreatic, bovine gallbladder and guinea pig brain CCK receptors, respectively. Devazepide (L-364,718) is effective for gastrointestinal disorders.

For research use only. We do not sell to patients.

Devazepide Chemical Structure

Devazepide Chemical Structure

CAS No. : 103420-77-5

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Description

Devazepide (L-364,718) is a potent, competitive, selective and orally active nonpeptide antagonist of cholecystokinin (CCK) receptor, with IC50s of 81 pM, 45 pM and 245 nM for rat pancreatic, bovine gallbladder and guinea pig brain CCK receptors, respectively. Devazepide (L-364,718) is effective for gastrointestinal disorders[1].

IC50 & Target

IC50: 45 pM (Rat pancreatic CCK receptor), 81 pM (Bovine gallbladder CCK receptor), 245 nM (Guinea pig brain CCK receptor)[1]

Molecular Weight

408.45

Formula

C₂₅H₂₀N₄O₂

CAS No.

103420-77-5

SMILES

O=C(C1=CC2=C(C=CC=C2)N1)N[[email protected]]3N=C(C4=CC=CC=C4)C5=CC=CC=C5N(C)C3=O

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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