1. GPCR/G Protein
    Neuronal Signaling
  2. Cholecystokinin Receptor
  3. LY288513

LY288513 

Cat. No.: HY-103357
Handling Instructions

LY288513, a selective non-peptide CCK-B receptor antagonist with an IC50 value of 16 nM. LY288513 possesses both anxiolytic and antipsychotic potential.

For research use only. We do not sell to patients.

LY288513 Chemical Structure

LY288513 Chemical Structure

CAS No. : 147523-65-7

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Description

LY288513, a selective non-peptide CCK-B receptor antagonist with an IC50 value of 16 nM. LY288513 possesses both anxiolytic and antipsychotic potential[1][2][3].

IC50 & Target

IC50: 16 nM (CCK-B receptor)[1]

In Vitro

LY288513 (10 nM; 2 days) suppresses the effects of CCK-8 on CD4+ T cell subset-specific transcription factors[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[2]

Cell Line: CD4+ T cells
Concentration: 10 nM
Incubation Time: 2 days
Result: Suppressed the effects of CCK-8 on CD4+ T cell subset-specific transcription factors.
In Vivo

LY288513 (3, 10 mg/kg, i.p.; 10, 30 mg/kg, p.o.) produces an anxiolytic-like action[3].
LY288513 (1000 mg/kg, p.o.) potentiates the effects of a CNS depressant, slightly lowered body temperature, and had modest sedative effects only at the highest dose examined[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male CD-l mice[3]
Dosage: 3, 10 mg/kg; 10, 30 mg/kg
Administration: I.p.; p.o.
Result: Displayed anxiolytic-like effects in the elevated plusmaze.
Molecular Weight

436.30

Formula

C₂₂H₁₈BrN₃O₂

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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LY288513
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HY-103357
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