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Referencia número: HY-117828

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PF-04756956

PF-04756956 is a highly potent type 1 cholecystokinin receptor (CCK1R) agonist (EC₅₀=0.47 nM). PF-04756956 is promising for research of obesity and related metabolic disorders.

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No. CAS: 1228934-52-8
Fòrmula: C₄₀H₃₉N₇O₂
Peso molecular:649.78

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

PF-04756956 Chemical Structure

No. CAS: 1228934-52-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

PF-04756956 is a highly potent type 1 cholecystokinin receptor (CCK1R) agonist (EC₅₀=0.47 nM). PF-04756956 is promising for research of obesity and related metabolic disorders^[1].

Ver todos los productos específicos de isoformas Cholecystokinin Receptor :

CCKAR
CCKBR

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	0.47 nM Compound: PF-04756956	Agonist activity at wild-type human CCK1R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis Agonist activity at wild-type human CCK1R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis	[PMID: 26654202]
CHO	IC₅₀	>1000 nM Compound: PF-04756956	Displacement of [125I-BDZ-1] from wild-type human CCK1R expressed in CHO cells after 60 mins by scintillation counter Displacement of [125I-BDZ-1] from wild-type human CCK1R expressed in CHO cells after 60 mins by scintillation counter	[PMID: 26654202]
CHO	IC₅₀	>1000 nM Compound: PF-04756956	Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter	[PMID: 26654202]
CHO	IC₅₀	14.7 nM Compound: 10e	Displacement of [125I]-CCK-2 from rat CCK1 receptor expressed in CHO cells after 90 mins by liquid scintillation counting Displacement of [125I]-CCK-2 from rat CCK1 receptor expressed in CHO cells after 90 mins by liquid scintillation counting	[PMID: 22424974]
CHO	IC₅₀	20.3 nM Compound: 10e	Displacement of [125I]-CCK-2 from human CCK1 receptor expressed in CHO cells after 90 mins by liquid scintillation counting Displacement of [125I]-CCK-2 from human CCK1 receptor expressed in CHO cells after 90 mins by liquid scintillation counting	[PMID: 22424974]
CHO	IC₅₀	35 nM Compound: PF-04756956	Displacement of [125I-CCK] from wild-type human CCK1R expressed in CHO cells after 60 mins by scintillation counter Displacement of [125I-CCK] from wild-type human CCK1R expressed in CHO cells after 60 mins by scintillation counter	[PMID: 26654202]

Chemical Information

No. CAS 1228934-52-8
Peso molecular 649.78
Fòrmula C₄₀H₃₉N₇O₂
SMILES

O=C1[C@@H](CC2=NNC3=C2C=CC=C3)C4=NN=C(C5=CC=CC=C5)N4C6=CC=CC=C6N1CC(N7[C@@H](CC8=CC(C)=CC(C)=C8)CCCC7)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Desai AJ, et al. Molecular Mechanism of Action of Triazolobenzodiazepinone Agonists of the Type 1 Cholecystokinin Receptor. Possible Cooperativity across the Receptor Homodimeric Complex. J Med Chem. 2015 Dec 24;58(24):9562-77. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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