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Cat. No.: HY-117828

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PF-04756956

PF-04756956 is a highly potent type 1 cholecystokinin receptor (CCK1R) agonist (EC₅₀=0.47 nM). PF-04756956 is promising for research of obesity and related metabolic disorders.

For research use only. We do not sell to patients.

CAS No.: 1228934-52-8
Formula: C₄₀H₃₉N₇O₂
Molecular Weight:649.78

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

PF-04756956 Chemical Structure

CAS No.: 1228934-52-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PF-04756956 is a highly potent type 1 cholecystokinin receptor (CCK1R) agonist (EC₅₀=0.47 nM). PF-04756956 is promising for research of obesity and related metabolic disorders^[1].

All Cholecystokinin Receptor Isoforms :

CCKAR
CCKBR

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	0.47 nM Compound: PF-04756956	Agonist activity at wild-type human CCK1R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis Agonist activity at wild-type human CCK1R expressed in CHO cells assessed as intracellular calcium response by fluorescence analysis	[PMID: 26654202]
CHO	IC₅₀	>1000 nM Compound: PF-04756956	Displacement of [125I-BDZ-1] from wild-type human CCK1R expressed in CHO cells after 60 mins by scintillation counter Displacement of [125I-BDZ-1] from wild-type human CCK1R expressed in CHO cells after 60 mins by scintillation counter	[PMID: 26654202]
CHO	IC₅₀	>1000 nM Compound: PF-04756956	Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter Displacement of [125I-BDZ-2] from wild-type human CCK2R expressed in CHO cells after 60 mins by scintillation counter	[PMID: 26654202]
CHO	IC₅₀	14.7 nM Compound: 10e	Displacement of [125I]-CCK-2 from rat CCK1 receptor expressed in CHO cells after 90 mins by liquid scintillation counting Displacement of [125I]-CCK-2 from rat CCK1 receptor expressed in CHO cells after 90 mins by liquid scintillation counting	[PMID: 22424974]
CHO	IC₅₀	20.3 nM Compound: 10e	Displacement of [125I]-CCK-2 from human CCK1 receptor expressed in CHO cells after 90 mins by liquid scintillation counting Displacement of [125I]-CCK-2 from human CCK1 receptor expressed in CHO cells after 90 mins by liquid scintillation counting	[PMID: 22424974]
CHO	IC₅₀	35 nM Compound: PF-04756956	Displacement of [125I-CCK] from wild-type human CCK1R expressed in CHO cells after 60 mins by scintillation counter Displacement of [125I-CCK] from wild-type human CCK1R expressed in CHO cells after 60 mins by scintillation counter	[PMID: 26654202]

Chemical Information

CAS No. 1228934-52-8
Molecular Weight 649.78
Formula C₄₀H₃₉N₇O₂
SMILES

O=C1[C@@H](CC2=NNC3=C2C=CC=C3)C4=NN=C(C5=CC=CC=C5)N4C6=CC=CC=C6N1CC(N7[C@@H](CC8=CC(C)=CC(C)=C8)CCCC7)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Desai AJ, et al. Molecular Mechanism of Action of Triazolobenzodiazepinone Agonists of the Type 1 Cholecystokinin Receptor. Possible Cooperativity across the Receptor Homodimeric Complex. J Med Chem. 2015 Dec 24;58(24):9562-77. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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PF-04756956

All Cholecystokinin Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PF-04756956 Related Classifications

HY-117828 Related Classifications