Lorglumide sodium
Based on 1 Customer Validation
Lorglumide sodium salt (CR-1409 sodium salt) is a potent cholecystokinin (CCK) receptor antagonist.
For research use only. We do not sell to patients.
- Purity: 99.19%
- CAS No.: 1021868-76-7
- Formula: C22H31Cl2N2NaO4
- Molecular Weight:481.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
CCK[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| AGS | IC50 |
289 nM
Compound: Lorglumide Sodium
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Antiproliferative activity against human AGS cells assessed as reduction in cell viability after 3 days by MTT assay
Antiproliferative activity against human AGS cells assessed as reduction in cell viability after 3 days by MTT assay
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10.1039/C6MD00052E |
| MAC13 | IC50 |
421 nM
Compound: Lorglumide Sodium
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Antiproliferative activity against mouse MAC13 cells assessed as reduction in cell viability after 3 days by MTT assay
Antiproliferative activity against mouse MAC13 cells assessed as reduction in cell viability after 3 days by MTT assay
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10.1039/C6MD00052E |
| MAC16 | IC50 |
861 nM
Compound: Lorglumide Sodium
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Antiproliferative activity against mouse MAC16 cells assessed as reduction in cell viability after 3 days by MTT assay
Antiproliferative activity against mouse MAC16 cells assessed as reduction in cell viability after 3 days by MTT assay
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10.1039/C6MD00052E |
| U-373MG ATCC | IC50 |
>5000 nM
Compound: Lorglumide Sodium
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Antiproliferative activity against human U373MG cells assessed as reduction in cell viability after 3 days by MTT assay
Antiproliferative activity against human U373MG cells assessed as reduction in cell viability after 3 days by MTT assay
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10.1039/C6MD00052E |
Chemical Information
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CAS No. 1021868-76-7
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Appearance Solid
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Molecular Weight 481.39
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Formula C22H31Cl2N2NaO4
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Color White to off-white
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SMILES
ClC1=C(C=CC(C(NC(CCC(O[Na])=O)C(N(CCCCC)CCCCC)=O)=O)=C1)Cl
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Synonyms
CR-1409 sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
H2O : ≥ 100 mg/mL (207.73 mM)
DMSO : 100 mg/mL (207.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.08 mg/mL (4.32 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.08 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (103.87 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.0773 mL | 10.3866 mL | 20.7732 mL | 51.9329 mL |
| 5 mM | 0.4155 mL | 2.0773 mL | 4.1546 mL | 10.3866 mL | |
| 10 mM | 0.2077 mL | 1.0387 mL | 2.0773 mL | 5.1933 mL | |
| 15 mM | 0.1385 mL | 0.6924 mL | 1.3849 mL | 3.4622 mL | |
| 20 mM | 0.1039 mL | 0.5193 mL | 1.0387 mL | 2.5966 mL | |
| 25 mM | 0.0831 mL | 0.4155 mL | 0.8309 mL | 2.0773 mL | |
| 30 mM | 0.0692 mL | 0.3462 mL | 0.6924 mL | 1.7311 mL | |
| 40 mM | 0.0519 mL | 0.2597 mL | 0.5193 mL | 1.2983 mL | |
| 50 mM | 0.0415 mL | 0.2077 mL | 0.4155 mL | 1.0387 mL | |
| 60 mM | 0.0346 mL | 0.1731 mL | 0.3462 mL | 0.8655 mL | |
| 80 mM | 0.0260 mL | 0.1298 mL | 0.2597 mL | 0.6492 mL | |
| 100 mM | 0.0208 mL | 0.1039 mL | 0.2077 mL | 0.5193 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Lorglumide sodium Related Classifications
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