Igmesine hydrochloride
Based on 1 Customer Validation
Igmesine hydrochloride (JO 1784) is an orally active σ-receptor ligand capable of blocking the increase in colonic electromechanical activity induced by emotional stress. Igmesine hydrochloride also eliminates the colonic motility stimulation induced by dopamine, as well as the stimulation induced by centrally injected D1 or D2 receptor agonists. Furthermore, Igmesine hydrochloride can block the colonic motility responses induced by corticotropin-releasing factor (CRF) and ES through central cholecystokinin (CCK) release and/or activation of supraspinal CCK pathways.
For research use only. We do not sell to patients.
- CAS No.: 130152-35-1
- Formula: C23H30ClN
- Molecular Weight:355.94
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
Chemical Information
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CAS No. 130152-35-1
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Appearance Solid
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Molecular Weight 355.94
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Formula C23H30ClN
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SMILES
CN(CC1CC1)C(CC)(C2=CC=CC=C2)C/C=C/C3=CC=CC=C3.Cl
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Synonyms
JO 1784 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
References
[1]. Gué M, et al. Reversal of CRF- and dopamine-induced stimulation of colonic motility by CCK and igmesine (JO 1784) in the rat. Br J Pharmacol. 1994 Mar;111(3):930-4. [Content Brief]
[2]. Roman F J, et al. JO 1784, a potent and selective ligand for rat and mouse brain σ‐sites[J]. Journal of Pharmacy and Pharmacology, 1990, 42(6): 439-440. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Igmesine hydrochloride Related Classifications
HY-169914 Related Classifications
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