130152-35-1
Chemical Structure
Igmesine hydrochloride
Synonym(s): JO 1784 hydrochloride
- CAS No.: 130152-35-1
- Formula:C23H30ClN
- Molecular Weight:355.94
InChIKey: SCHQQPAJNUHKSV-RSGUCCNWSA-N
SMILES: CN(CC1CC1)C(CC)(C2=CC=CC=C2)C/C=C/C3=CC=CC=C3.Cl
Biological Activity: Igmesine hydrochloride (JO 1784) is an orally active σ-receptor ligand capable of blocking the increase in colonic electromechanical activity induced by emotional stress. Igmesine hydrochloride also eliminates the colonic motility stimulation induced by dopamine, as well as the stimulation induced by centrally injected D1 or D2 receptor agonists. Furthermore, Igmesine hydrochloride can block the colonic motility responses induced by corticotropin-releasing factor (CRF) and ES through central cholecystokinin (CCK) release and/or activation of supraspinal CCK pathways[1][2].
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Igmesine hydrochloride | Igmesine hydrochloride (JO 1784) is an orally active σ-receptor ligand capable of blocking the increase in colonic electromechanical activity induced by emotional stress. Igmesine hydrochloride also eliminates the colonic motility stimulation induced by dopamine, as well as the stimulation induced by centrally injected D1 or D2 receptor agonists. Furthermore, Igmesine hydrochloride can block the colonic motility responses induced by corticotropin-releasing factor (CRF) and ES through central cholecystokinin (CCK) release and/or activation of supraspinal CCK pathways. | |||||||||||||||||||||
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- [1]. Gué M, et al. Reversal of CRF- and dopamine-induced stimulation of colonic motility by CCK and igmesine (JO 1784) in the rat. Br J Pharmacol. 1994 Mar;111(3):930-4. [Content Brief]
- [2]. Roman F J, et al. JO 1784, a potent and selective ligand for rat and mouse brain σ‐sites[J]. Journal of Pharmacy and Pharmacology, 1990, 42(6): 439-440. [Content Brief]
Keywords
