Duodenal Ulcer

A duodenal ulcer is a peptic ulcer that develops in the lining of the duodenum, the first part of the small intestine, primarily caused by Helicobacter pylori infection or the use of nonsteroidal anti-inflammatory drugs (NSAIDs). It presents with characteristic dull or burning pain in the upper abdomen, typically occurring between meals and relieved by eating or antacids. The condition is part of peptic ulcer disease (PUD), affecting approximately 1% of the global population. Treatment involves acid-suppressing medications and eradication of H. pylori infection over a 4–8 week period. Lifestyle modifications, including avoidance of smoking and alcohol, are key to prevention. Duodenal ulcers result from an imbalance between mucosal defensive factors and aggressive agents such as gastric acid and pepsin, leading to mucosal breakdown and necrosis extending into the submucosa.

References:

[1]. Duodenal Ulcer. diseasedb.

Duodenal Ulcer (1):

Targets:	NO Synthase (1) Sigma Receptor (1)

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure

HY-108515

(+)-Igmesine hydrochloride		99.0%
(+)-Igmesine hydrochloride (JO1784) is an orally active and selective σ₁ receptor ligand with an IC₅₀ of 39 nM. (+)-Igmesine hydrochloride binds σ₁ receptors to activate G-proteins and modulate Ca²⁺ uptake. (+)-Igmesine (hydrochloride) attenuates ischaemia-induced nitric oxide synthase activity and hyperactivity. (+)-Igmesine hydrochloride can be used for the research of duodenal ulcers, gastric ulcers, and cerebral ischaemia.

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