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Cat. No.: HY-116576

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LY219057

LY219057 is a potent antagonist of cholecystokinin octapeptide (CCK-8), with the ID₅₀ of 287.5 nM.

For research use only. We do not sell to patients.

CAS No.: 150351-93-2
Formula: C₂₃H₁₇ClF₃N₃OS
Molecular Weight:475.91

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

LY219057 Chemical Structure

CAS No.: 150351-93-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

LY219057 is a potent antagonist of cholecystokinin octapeptide (CCK-8), with the ID₅₀ of 287.5 nM^[1]^[2].

All Cholecystokinin Receptor Isoforms :

CCKAR
CCKBR

Chemical Information

CAS No. 150351-93-2
Molecular Weight 475.91
Formula C₂₃H₁₇ClF₃N₃OS
SMILES

FC(F)(F)C(C=C1NC(N2[C@@H](C3=CC=CC=C3)[C@H](C4=CC=CC=C4)C(N2)=O)=S)=C(C=C1)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

CCK-8/WST-8 Cell Proliferation Assay
The CCK-8/WST-8 assay is based on the reduction of the water-soluble tetrazolium salt WST-8 to a water-soluble formazan product by cellular dehydrogenases in metabolically active cells, where the generated formazan amount is proportional to the number of living cells and is quantified by measuring absorbance in the visible range, providing a colorimetric readout for cell viability and proliferation assessment. This class of tetrazolium-based assays improves upon earlier MTT-based systems by producing a water-soluble formazan, eliminating the need for organic solubilization steps and enabling direct spectrophotometric measurement in culture medium.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. T Akiyama, et al. Characterization of a new diphenylpyrazolidinone cholecystokinin antagonist in vitro isolated rat pancreatic acini. Int J Pancreatol. 1993 Oct;14(2):167-73. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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