NFYB - nuclear transcription factor Y subunit beta Gene
Also Known as HAP3; CBF-A; CBF-B; NF-YB
Species: Homo sapiens
About NFYB
This gene has 5 transcripts (splice variants), 244 orthologues and 2 paralogues. Ubiquitous expression in prostate (RPKM 10.4), endometrium (RPKM 9.3) and 25 other tissues.
Summary
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. [provided by RefSeq, Jul 2008]
NFYB Products (16)
| mRNA | Protein | Name |
|---|---|---|
| NM_001414518.1 | NP_001401447.1 | nuclear transcription factor Y subunit beta isoform a |
| NM_001414519.1 | NP_001401448.1 | nuclear transcription factor Y subunit beta isoform a |
| NM_001414520.1 | NP_001401449.1 | nuclear transcription factor Y subunit beta isoform b |
| NM_001414521.1 | NP_001401450.1 | nuclear transcription factor Y subunit beta isoform b |
| NM_001414522.1 | NP_001401451.1 | nuclear transcription factor Y subunit beta isoform c |
| NM_001414523.1 | NP_001401452.1 | nuclear transcription factor Y subunit beta isoform d |
| NM_001414524.1 | NP_001401453.1 | nuclear transcription factor Y subunit beta isoform d |
| NM_001414525.1 | NP_001401454.1 | nuclear transcription factor Y subunit beta isoform d |
| NM_001414526.1 | NP_001401455.1 | nuclear transcription factor Y subunit beta isoform d |
| NM_001414527.1 | NP_001401456.1 | nuclear transcription factor Y subunit beta isoform e |
| NM_001414528.1 | NP_001401457.1 | nuclear transcription factor Y subunit beta isoform f |
| NM_001414529.1 | NP_001401458.1 | nuclear transcription factor Y subunit beta isoform f |
| NM_001414530.1 | NP_001401459.1 | nuclear transcription factor Y subunit beta isoform g |
| NM_001414531.1 | NP_001401460.1 | nuclear transcription factor Y subunit beta isoform h |
| NM_001414532.1 | NP_001401461.1 | nuclear transcription factor Y subunit beta isoform h |
| NM_006166.4 | NP_006157.1 | nuclear transcription factor Y subunit beta isoform b |
NFYB Protein Structure
CBFD_NFYB_HMF: Histone-like transcription factor (CBF/NF-Y) and archaeal histone (58 - 122)
- 0
- 100
- 207 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
nuclear transcription factor Y subunit beta |
|
NFYB Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
NFYB | P25208 | NFYA | Homo sapiens | P23511-2 | 32296183 | |
|
Intra
|
NFYB | P25208 | NFYA | Homo sapiens | P23511-2 | 26496610 | |
|
Intra
|
NFYB | P25208 | NFYA | Homo sapiens | P23511-2 | 32296183 | |
|
Intra
|
NFYB | P25208 | NFYC | Homo sapiens | Q13952-2 | 32296183 | |
|
Intra
|
NFYB | P25208 | MEOX2 | Homo sapiens | Q6FHY5 | 32296183 | |
|
Intra
|
NFYB | P25208 | MEOX2 | Homo sapiens | Q6FHY5 | 32296183 | |
|
Intra
|
NFYB | P25208 | MEOX2 | Homo sapiens | Q6FHY5 | 32296183 | |
|
Intra
|
NFYB | P25208 | TP53 | Homo sapiens | P04637 | 23734815 | |
|
Intra
|
NFYB | P25208 | TP53 | Homo sapiens | P04637 | 16959611 | |
|
Intra
|
NFYB | P25208 | NFYA | Homo sapiens | P23511 | 25416956 | |
|
Intra
|
NFYB | P25208 | NFYA | Homo sapiens | P23511 | 16959611 | |
|
Intra
|
NFYB | P25208 | NFYC | Homo sapiens | Q13952 | 26496610 | |
|
Intra
|
NFYB | P25208 | NFYC | Homo sapiens | Q13952 | 12401788 | |
|
Intra
|
NFYB | P25208 | NFYC | Homo sapiens | Q13952 | 21988832 | |
|
Intra
|
NFYB | P25208 | DRAP1 | Homo sapiens | Q14919 | 16189514 | |
|
Intra
|
NFYB | P25208 | AGTRAP | Homo sapiens | Q6RW13 | 25416956 | |
|
Intra
|
NFYB | P25208 | AGTRAP | Homo sapiens | Q6RW13 | 25416956 | |
|
Intra
|
NFYB | P25208 | POLE4 | Homo sapiens | Q9NR33 | 25416956 | |
|
Intra
|
NFYB | P25208 | POLE4 | Homo sapiens | Q9NR33 | 32296183 | |
|
Intra
|
NFYB | P25208 | POLE4 | Homo sapiens | Q9NR33 | 25416956 |
NFYB Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P811114 | NFYB Antibody | WB, IHC-P | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Cyclosporiasis |
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS09272 | NFYB Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS22255 | Nfyb Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | NFYB | MGD | MGI:97317 |
| Macaca mulatta | NFYB | VGNC | VGNC:97795 |
| Felis catus | NFYB | VGNC | VGNC:97525 |
| Rattus norvegicus | NFYB | RGD | RGD:3172 |
| Bos taurus | NFYB | VGNC | VGNC:32056 |
| Canis familiaris | NFYB | VGNC | VGNC:43791 |
| Others | NFYB | NCBI |
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