NFYC - nuclear transcription factor Y subunit gamma Gene

Homo sapiens

Also known as HSM; CBFC; HAP5; CBF-C; NF-YC; H1TF2A

Gene ID: 4802 | Gene type: protein coding

About NFYC

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:40,691,704-40,771,603 (from NCBI)

This gene has 24 transcripts (splice variants), 209 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 9.6), heart (RPKM 9.5) and 25 other tissues.

Summary

This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

NFYC Products(7)

mRNA	Protein	Name
NM_001142587.2	NP_001136059.1	nuclear transcription factor Y subunit gamma isoform 3
NM_001142588.2	NP_001136060.1	nuclear transcription factor Y subunit gamma isoform 1
NM_001142589.2	NP_001136061.1	nuclear transcription factor Y subunit gamma isoform 4
NM_001142590.2	NP_001136062.1	nuclear transcription factor Y subunit gamma isoform 5
NM_001308114.1	NP_001295043.1	nuclear transcription factor Y subunit gamma isoform 6
NM_001308115.2	NP_001295044.1	nuclear transcription factor Y subunit gamma isoform 7
NM_014223.5	NP_055038.2	nuclear transcription factor Y subunit gamma isoform 2

NFYC Protein Structure

CBFD_NFYB_HMF

0
100
200
300
400
458 a.a.

Protein Preferred Names

Protein Names

nuclear transcription factor Y subunit gamma

CAAT box DNA-binding protein subunit C

Related Diseases

Diseases

Alias

Choroid Plexus Cancer

Choroid Plexus Carcinoma	Choroid Plexus Neoplasms
Choroid Plexus Neoplasm	Tumor Of Choroid Plexus
Tumor Of The Choroid Plexus	Choroid Plexus Tumor
Choroid Plexus Tumors	Anaplastic Choroid Plexus Papilloma
Choroid Plexus Papilloma Nos	Papilloma Of Choroid Plexus
Plexus Choroideus Papilloma	Choroid Plexus Papilloma In Fourth Ventricle
Plexus Choroideus Papilloma In Fourth Ventricle

Neonatal Candidiasis

Neonatal Candida Infection	Neonatal Monilia Infection
Neonatal Moniliasis

Adult Acute Monocytic Leukemia

Adult Acute Monoblastic And Acute Monocytic Leukemia

Cyclosporiasis

Cyclosporosis

Cyclospora Infection

Atypical Choroid Plexus Papilloma

Atypical Papilloma Of Choroid Plexus

Atypical Cpp

Multiple Epiphyseal Dysplasia Due To Collagen 9 Anomaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09273	NFYC Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NFYC	VGNC	VGNC:106416
Felis catus	NFYC	VGNC	VGNC:68492
Canis familiaris	NFYC	VGNC	VGNC:43792
Bos taurus	NFYC	VGNC	VGNC:32057
Mus musculus	NFYC	MGD	MGI:107901
Rattus norvegicus	NFYC	RGD	RGD:3173