AGTRAP - angiotensin II receptor associated protein Gene

Also Known as ATRAP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57085

About AGTRAP

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:11,736,136-11,750,769 (from NCBI)

This gene has 14 transcripts (splice variants) and 177 orthologues. Ubiquitous expression in bone marrow (RPKM 38.0), prostate (RPKM 28.1) and 25 other tissues.

Summary

This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

AGTRAP Products (5)

mRNA	Protein	Name
NM_001040194.2	NP_001035284.1	type-1 angiotensin II receptor-associated protein isoform b
NM_001040195.2	NP_001035285.1	type-1 angiotensin II receptor-associated protein isoform c
NM_001040196.2	NP_001035286.1	type-1 angiotensin II receptor-associated protein isoform d
NM_001040197.2	NP_001035287.1	type-1 angiotensin II receptor-associated protein isoform e
NM_020350.5	NP_065083.3	type-1 angiotensin II receptor-associated protein isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AGTRAP Protein Structure

AGTRAP

0
100
159 a.a.

Protein Preferred Names	Protein Names
type-1 angiotensin II receptor-associated protein	AT1 receptor-associated protein

AGTRAP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AGTRAP	Q6RW13	SUCLA2	Homo sapiens	E5KS60	Y2H Array	25416956
Intra	AGTRAP	Q6RW13	SSX5	Homo sapiens	O60225	Validated Y2H	25416956
Intra	AGTRAP	Q6RW13	SSX5	Homo sapiens	O60225	Y2H Array	25416956
Intra	AGTRAP	Q6RW13	SSX5	Homo sapiens	O60225	Y2H Array	29892012
Intra	AGTRAP	Q6RW13	SSX5	Homo sapiens	O60225	Y2H Array	31515488
Intra	AGTRAP	Q6RW13	GDNF	Homo sapiens	P39905	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	GDNF	Homo sapiens	P39905	Validated Y2H	25416956
Intra	AGTRAP	Q6RW13	GAD1	Homo sapiens	Q8IVA8	Validated Y2H	25416956
Intra	AGTRAP	Q6RW13	FASTKD3	Homo sapiens	Q14CZ7	Y2H Array	25416956
Intra	AGTRAP	Q6RW13	FASTKD3	Homo sapiens	Q14CZ7	Validated Y2H	25416956
Intra	AGTRAP	Q6RW13	SYT16	Homo sapiens	Q17RD7	Y2H Array	31515488
Intra	AGTRAP	Q6RW13	SYT16	Homo sapiens	Q17RD7	Validated Y2H	25416956
Intra	AGTRAP	Q6RW13	SYT16	Homo sapiens	Q17RD7	Y2H Array	29892012
Intra	AGTRAP	Q6RW13	PBX3	Homo sapiens	Q5JS98	Y2H Array	25416956
Intra	AGTRAP	Q6RW13	PBX3	Homo sapiens	Q5JS98	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	PTPN9	Homo sapiens	Q6IQ43	Y2H Array	25416956
Intra	AGTRAP	Q6RW13	STAG3L1	Homo sapiens	Q7L1H2	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	STAG3L1	Homo sapiens	Q7L1H2	Validated Y2H	25416956
Intra	AGTRAP	Q6RW13	STAG3L1	Homo sapiens	Q7L1H2	Y2H Array	25416956
Intra	AGTRAP	Q6RW13	BPIFA2	Homo sapiens	Q96DR5	Y2H Array	25416956
Intra	AGTRAP	Q6RW13	BPIFA2	Homo sapiens	Q96DR5	Validated Y2H	25416956
Intra	AGTRAP	Q6RW13	MCEE	Homo sapiens	Q96PE7	Validated Y2H	25416956
Intra	AGTRAP	Q6RW13	MCEE	Homo sapiens	Q96PE7	Y2H Array	25416956
Intra	AGTRAP	Q6RW13	MCEE	Homo sapiens	Q96PE7	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	MCEE	Homo sapiens	Q96PE7	Y2H Array	31515488
Intra	AGTRAP	Q6RW13	H4C7	Homo sapiens	Q99525	Y2H Array	25416956
Intra	AGTRAP	Q6RW13	H4C7	Homo sapiens	Q99525	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	SSX3	Homo sapiens	Q99909	Validated Y2H	25416956
Intra	AGTRAP	Q6RW13	SSX3	Homo sapiens	Q99909	Y2H Array	25416956
Intra	AGTRAP	Q6RW13	MUTYH	Homo sapiens	Q9UIF7-3	Validated Y2H	25416956
Intra	AGTRAP	Q6RW13	MUTYH	Homo sapiens	Q9UIF7-3	Y2H Array	25416956
Intra	AGTRAP	Q6RW13	NDRG4	Homo sapiens	Q9ULP0	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	NDRG4	Homo sapiens	Q9ULP0	Y2H Array	25416956
Intra	AGTRAP	Q6RW13	ISCU	Homo sapiens	Q9H1K1	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	TFAM	Homo sapiens	Q00059	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	TFAM	Homo sapiens	Q00059	Validated Y2H	25416956
Intra	AGTRAP	Q6RW13	ALDH18A1	Homo sapiens	P54886	Validated Y2H	25416956
Intra	AGTRAP	Q6RW13	HSCB	Homo sapiens	Q8IWL3	Y2H Array	31515488
Intra	AGTRAP	Q6RW13	HSCB	Homo sapiens	Q8IWL3	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	HSCB	Homo sapiens	Q8IWL3	Y2H Array	25416956
Intra	AGTRAP	Q6RW13	AP3M1	Homo sapiens	Q9Y2T2	Validated Y2H	25416956
Intra	AGTRAP	Q6RW13	AP3M1	Homo sapiens	Q9Y2T2	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	FARS2	Homo sapiens	O95363	Y2H Array	25416956
Intra	AGTRAP	Q6RW13	PIMREG	Homo sapiens	Q9BSJ6	Y2H Array	25416956
Intra	AGTRAP	Q6RW13	PIMREG	Homo sapiens	Q9BSJ6	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	FAM114A1	Homo sapiens	Q8IWE2	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	RMDN2	Homo sapiens	Q96LZ7	Y2H Array	25416956
Intra	AGTRAP	Q6RW13	RMDN2	Homo sapiens	Q96LZ7	Validated Y2H	25416956
Intra	AGTRAP	Q6RW13	SNX1	Homo sapiens	Q13596	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	SNX1	Homo sapiens	Q13596	Y2H Array	25416956
Intra	AGTRAP	Q6RW13	ACSF2	Homo sapiens	Q96CM8	Y2H Array	31515488
Intra	AGTRAP	Q6RW13	TXN2	Homo sapiens	Q99757	Y2H Array	25416956
Intra	AGTRAP	Q6RW13	TXN2	Homo sapiens	Q99757	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	TXN2	Homo sapiens	Q99757	Validated Y2H	25416956
Intra	AGTRAP	Q6RW13	GTF3C1	Homo sapiens	Q12789	Validated Y2H	25416956
Intra	AGTRAP	Q6RW13	HMGB1	Homo sapiens	P09429	Validated Y2H	25416956
Intra	AGTRAP	Q6RW13	HMGB1	Homo sapiens	P09429	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	HMGB1	Homo sapiens	P09429	Y2H Array	25416956
Intra	AGTRAP	Q6RW13	NFYB	Homo sapiens	P25208	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	HARS2	Homo sapiens	P49590	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	HARS2	Homo sapiens	P49590	Y2H Array	25416956
Intra	AGTRAP	Q6RW13	NKG7	Homo sapiens	Q16617	Y2H Array	25416956
Intra	AGTRAP	Q6RW13	CD160	Homo sapiens	O95971	Validated Y2H	25416956
Intra	AGTRAP	Q6RW13	CD160	Homo sapiens	O95971	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	PCTP	Homo sapiens	Q9UKL6	Y2H Array	25416956
Intra	AGTRAP	Q6RW13	TUBA1B	Homo sapiens	P68363	Y2H Array	25416956
Intra	AGTRAP	Q6RW13	ECPAS	Homo sapiens	Q5VYK3	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	ECPAS	Homo sapiens	Q5VYK3	Validated Y2H	25416956
Intra	AGTRAP	Q6RW13	ECPAS	Homo sapiens	Q5VYK3	Y2H Array	25416956
Intra	AGTRAP	Q6RW13	MRM1	Homo sapiens	Q6IN84	Validated Y2H	25416956
Intra	AGTRAP	Q6RW13	MRM1	Homo sapiens	Q6IN84	Y2H Array	25416956
Intra	AGTRAP	Q6RW13	TCEANC2	Homo sapiens	Q96MN5	Validated Y2H	25416956
Intra	AGTRAP	Q6RW13	TCEANC2	Homo sapiens	Q96MN5	Y2H Array	25416956
Intra	AGTRAP	Q6RW13	ARFIP2	Homo sapiens	P53365	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	ARFIP2	Homo sapiens	P53365	Validated Y2H	25416956
Intra	AGTRAP	Q6RW13	TBRG4	Homo sapiens	Q969Z0	Y2H Array	25416956
Intra	AGTRAP	Q6RW13	MYG1	Homo sapiens	Q9HB07	Y2H Array	31515488
Intra	AGTRAP	Q6RW13	CAPNS1	Homo sapiens	P04632	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	CAPNS1	Homo sapiens	P04632	Y2H Array	25416956
Intra	AGTRAP	Q6RW13	GABARAPL2	Homo sapiens	P60520	Validated Y2H	25416956
Intra	AGTRAP	Q6RW13	GABARAPL2	Homo sapiens	P60520	Y2H Array	25416956
Intra	AGTRAP	Q6RW13	GABARAPL2	Homo sapiens	P60520	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	NFU1	Homo sapiens	Q9UMS0	Validated Y2H	25416956
Intra	AGTRAP	Q6RW13	NFU1	Homo sapiens	Q9UMS0	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	LMO2	Homo sapiens	P25791	Validated Y2H	25416956
Intra	AGTRAP	Q6RW13	LMO2	Homo sapiens	P25791	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	MIEF1	Homo sapiens	Q9NQG6	Y2H Array	25416956
Intra	AGTRAP	Q6RW13	MIEF1	Homo sapiens	Q9NQG6	Validated Y2H	25416956
Intra	AGTRAP	Q6RW13	FHIP1B	Homo sapiens	Q8N612	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	FHIP1B	Homo sapiens	Q8N612	Validated Y2H	25416956
Intra	AGTRAP	Q6RW13	FHIP1B	Homo sapiens	Q8N612	Y2H Array	25416956
Intra	AGTRAP	Q6RW13	SPG21	Homo sapiens	Q9NZD8	Y2H Array	31515488
Intra	AGTRAP	Q6RW13	SPG21	Homo sapiens	Q9NZD8	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	PTPN9	Homo sapiens	P43378	Y2H	21516116
Intra	AGTRAP	Q6RW13	PTPN9	Homo sapiens	P43378	Y2H Array	31515488
Intra	AGTRAP	Q6RW13	PTPN9	Homo sapiens	P43378	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	PTPN9	Homo sapiens	P43378	Y2H Array	25416956
Intra	AGTRAP	Q6RW13	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	FATE1	Homo sapiens	Q969F0	Validated Y2H	25416956
Intra	AGTRAP	Q6RW13	COQ8A	Homo sapiens	Q8NI60	Y2H Array	31515488
Intra	AGTRAP	Q6RW13	COQ8A	Homo sapiens	Q8NI60	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	COQ8A	Homo sapiens	Q8NI60	Validated Y2H	25416956
Intra	AGTRAP	Q6RW13	COQ8A	Homo sapiens	Q8NI60	Y2H Array	25416956
Intra	AGTRAP	Q6RW13	PITPNC1	Homo sapiens	Q9UKF7	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	MIEF2	Homo sapiens	Q96C03	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	MIEF2	Homo sapiens	Q96C03	Validated Y2H	25416956
Intra	AGTRAP	Q6RW13	PDHX	Homo sapiens	O00330	Y2H Array	31515488
Intra	AGTRAP	Q6RW13	PDHX	Homo sapiens	O00330	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	PDHX	Homo sapiens	O00330	Y2H	21516116
Intra	AGTRAP	Q6RW13	MTERF3	Homo sapiens	Q96E29	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	GAD2	Homo sapiens	Q05329	Validated Y2H	25416956
Intra	AGTRAP	Q6RW13	GAD2	Homo sapiens	Q05329	Y2H Array	25416956
Intra	AGTRAP	Q6RW13	GAD2	Homo sapiens	Q05329	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	TPD52L3	Homo sapiens	Q96J77	Y2H Prey Pooling	25416956
Intra	AGTRAP	Q6RW13	TPD52L3	Homo sapiens	Q96J77	Validated Y2H	25416956
Intra	AGTRAP	Q6RW13	ARAF	Homo sapiens	Q96II5	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hypertensive Retinopathy
Childhood Astrocytic Tumor	Juvenile Astrocytoma Pediatric Astrocytoma
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00472	AGTRAP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21819	Agtrap Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28335	Agtrap Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	AGTRAP	VGNC	VGNC:69604
Rattus norvegicus	AGTRAP	RGD	RGD:1359346
Bos taurus	AGTRAP	VGNC	VGNC:25747
Mus musculus	AGTRAP	MGD	MGI:1339977
Canis familiaris	AGTRAP	VGNC	VGNC:37722
Others	AGTRAP	NCBI