FASTKD3 - FASTK mitochondrial RNA regulator 3 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79072

Summary

This gene encodes a member of a small family of Fas-activated serine/threonine kinase domain (FASTKD) containing proteins that share an amino terminal mitochondrial targeting domain and multiple carboxy terminal FAST domains as well as a putative RNA-binding RAP domain. The members of this family are ubiquitously expressed and are generally most abundant in mitochondria-enriched tissues such as heart, skeletal muscle and brown-adipose tissue. Some members of this protein family may play a role in Apoptosis. The protein encoded by this gene interacts with components of the mitochondrial respiratory and translation networks. A pseudogene of this gene is also present on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Ubiquitous expression in kidney (RPKM 3.9), lymph node (RPKM 3.8) and 25 other tissues.

FASTKD3 Products (1)

mRNA Protein Name
NG_033101.1 [RefSeqGene]
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in mitochondrial cytochrome c oxidase assembly IDA
IDA: Inferred from direct assay
27789713 GOA
involved in positive regulation of mitochondrial translation IDA
IDA: Inferred from direct assay
27789713 GOA
involved in regulation of mitochondrial mRNA stability IDA
IDA: Inferred from direct assay
27789713 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
20869947 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FASTKD3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FASTKD3 Q14CZ7 FAM9B Homo sapiens Q8IZU0 31515488
Intra
FASTKD3 Q14CZ7 FAM9B Homo sapiens Q8IZU0 25416956
Intra
FASTKD3 Q14CZ7 AGTRAP Homo sapiens Q6RW13 25416956
Intra
FASTKD3 Q14CZ7 MAGEA12 Homo sapiens P43365 25416956
Intra
FASTKD3 Q14CZ7 MAGEA12 Homo sapiens P43365 25416956
Cross: Cross-species interaction Intra: Intraspecies interaction