FASTKD3 - FASTK mitochondrial RNA regulator 3 Gene
Species: Homo sapiens
Summary
This gene encodes a member of a small family of Fas-activated serine/threonine kinase domain (FASTKD) containing proteins that share an amino terminal mitochondrial targeting domain and multiple carboxy terminal FAST domains as well as a putative RNA-binding RAP domain. The members of this family are ubiquitously expressed and are generally most abundant in mitochondria-enriched tissues such as heart, skeletal muscle and brown-adipose tissue. Some members of this protein family may play a role in Apoptosis. The protein encoded by this gene interacts with components of the mitochondrial respiratory and translation networks. A pseudogene of this gene is also present on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Ubiquitous expression in kidney (RPKM 3.9), lymph node (RPKM 3.8) and 25 other tissues.
FASTKD3 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NG_033101.1 [RefSeqGene] |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
25416956 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in mitochondrial cytochrome c oxidase assembly |
IDA
IDA: Inferred from direct assay
|
27789713 | GOA |
| involved in positive regulation of mitochondrial translation |
IDA
IDA: Inferred from direct assay
|
27789713 | GOA |
| involved in regulation of mitochondrial mRNA stability |
IDA
IDA: Inferred from direct assay
|
27789713 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in mitochondrion |
IDA
IDA: Inferred from direct assay
|
20869947 | GOA |
FASTKD3 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
FASTKD3 | Q14CZ7 | FAM9B | Homo sapiens | Q8IZU0 | 31515488 | |
|
Intra
|
FASTKD3 | Q14CZ7 | FAM9B | Homo sapiens | Q8IZU0 | 25416956 | |
|
Intra
|
FASTKD3 | Q14CZ7 | AGTRAP | Homo sapiens | Q6RW13 | 25416956 | |
|
Intra
|
FASTKD3 | Q14CZ7 | MAGEA12 | Homo sapiens | P43365 | 25416956 | |
|
Intra
|
FASTKD3 | Q14CZ7 | MAGEA12 | Homo sapiens | P43365 | 25416956 |