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FATE1 - fetal and adult testis expressed 1 Gene

Also Known as CT43; FATE

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 89885

About FATE1

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:151,716,035-151,723,194 (from NCBI)

This gene has 2 transcripts (splice variants) and 77 orthologues. Restricted expression toward testis (RPKM 120.2).

Summary

This gene encodes a cancer-testis antigen that is highly expressed in hepatocellular carcinomas and Other tumors and weakly expressed in normal tissues except testis. The protein is strongly expressed in spermatogonia, primary spermatocytes, and Sertoli cells in seminiferous tubules. This protein may have a role in the control of early testicular differentiation and cell proliferation. [provided by RefSeq, Jan 2010]

FATE1 Products (1)

mRNA	Protein	Name
NM_033085.3	NP_149076.1	fetal and adult testis-expressed transcript protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables ubiquitin protein ligase binding	IDA IDA: Inferred from direct assay	26567849	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	12865919	GOA
involved in negative regulation of mitochondrial calcium ion concentration	IDA IDA: Inferred from direct assay	12865919	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondria-associated endoplasmic reticulum membrane contact site	IDA IDA: Inferred from direct assay	12865919	GOA
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	12865919	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FATE1 Protein Structure

Miff

0
100
183 a.a.

Protein Preferred Names	Protein Names
fetal and adult testis-expressed transcript protein	BJ-HCC-2 antigen

FATE1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FATE1	Q969F0	GPR25	Homo sapiens	O00155	Validated Y2H	25416956
Intra	FATE1	Q969F0	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	FATE1	Q969F0	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	FATE1	Q969F0	LY75	Homo sapiens	O60449-3	Y2H Array	25416956
Intra	FATE1	Q969F0	SNAP47	Homo sapiens	Q5SQN1	Y2H Array	25416956
Intra	FATE1	Q969F0	AQP9	Homo sapiens	Q6FGT0	Y2H Array	25416956
Intra	FATE1	Q969F0	NRSN1	Homo sapiens	Q8IZ57	Y2H Prey Pooling	25416956
Intra	FATE1	Q969F0	NRSN1	Homo sapiens	Q8IZ57	Validated Y2H	25416956
Intra	FATE1	Q969F0	NRSN1	Homo sapiens	Q8IZ57	Y2H Array	25416956
Intra	FATE1	Q969F0	PRRG2	Homo sapiens	Q8TAS3	Y2H Prey Pooling	25416956
Intra	FATE1	Q969F0	PRRG2	Homo sapiens	Q8TAS3	Y2H Array	25416956
Intra	FATE1	Q969F0	SYNPR	Homo sapiens	Q8TBG9	Validated Y2H	25416956
Intra	FATE1	Q969F0	MR1	Homo sapiens	Q95460	Validated Y2H	25416956
Intra	FATE1	Q969F0	SLC41A2	Homo sapiens	Q96JW4	Validated Y2H	32296183
Intra	FATE1	Q969F0	TMEM74	Homo sapiens	Q96NL1	Y2H Prey Pooling	25416956
Intra	FATE1	Q969F0	SEC22C	Homo sapiens	Q9BRL7	Validated Y2H	25416956
Intra	FATE1	Q969F0	SEC22C	Homo sapiens	Q9BRL7	Y2H Prey Pooling	25416956
Intra	FATE1	Q969F0	MARCHF2	Homo sapiens	Q9P0N8	Validated Y2H	32296183
Intra	FATE1	Q969F0	MARCHF2	Homo sapiens	Q9P0N8	Y2H Array	25416956
Intra	FATE1	Q969F0	KCNS2	Homo sapiens	Q9ULS6	Validated Y2H	25416956
Intra	FATE1	Q969F0	KCNS2	Homo sapiens	Q9ULS6	Validated Y2H	32296183
Intra	FATE1	Q969F0	RPRM	Homo sapiens	Q9NS64	Y2H Prey Pooling	25416956
Intra	FATE1	Q969F0	RPRM	Homo sapiens	Q9NS64	Validated Y2H	25416956
Intra	FATE1	Q969F0	RPRM	Homo sapiens	Q9NS64	Validated Y2H	32296183
Intra	FATE1	Q969F0	RPRM	Homo sapiens	Q9NS64	Y2H Array	25416956
Intra	FATE1	Q969F0	MFF	Homo sapiens	Q9GZY8-5	Validated Y2H	32296183
Intra	FATE1	Q969F0	MFF	Homo sapiens	Q9GZY8-5	Y2H Array	32296183
Intra	FATE1	Q969F0	MFF	Homo sapiens	Q9GZY8-5	Y2H Prey Pooling	32296183
Intra	FATE1	Q969F0	LNPEP	Homo sapiens	Q9UIQ6-2	Validated Y2H	32296183
Intra	FATE1	Q969F0	CALN1	Homo sapiens	Q9BXU9	Validated Y2H	32296183
Intra	FATE1	Q969F0	GINM1	Homo sapiens	Q9NU53	Validated Y2H	32296183
Intra	FATE1	Q969F0	PKMYT1	Homo sapiens	Q99640-2	Validated Y2H	32296183
Intra	FATE1	Q969F0	NDUFB11	Homo sapiens	Q9NX14	Validated Y2H	32296183
Intra	FATE1	Q969F0	NDUFB11	Homo sapiens	Q9NX14	Validated Y2H	25416956
Intra	FATE1	Q969F0	ASGR2	Homo sapiens	P07307-3	Y2H Prey Pooling	32296183
Intra	FATE1	Q969F0	ASGR2	Homo sapiens	P07307-3	Y2H Array	32296183
Intra	FATE1	Q969F0	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	FATE1	Q969F0	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	FATE1	Q969F0	CSF2RA	Homo sapiens	P15509	Y2H Prey Pooling	25416956
Intra	FATE1	Q969F0	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	FATE1	Q969F0	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	FATE1	Q969F0	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	FATE1	Q969F0	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	FATE1	Q969F0	MARCHF5	Homo sapiens	Q9NX47	Y2H Array	25416956
Intra	FATE1	Q969F0	MARCHF5	Homo sapiens	Q9NX47	Y2H Array	31515488
Intra	FATE1	Q969F0	USP20	Homo sapiens	Q9Y2K6	Validated Y2H	25416956
Intra	FATE1	Q969F0	CERS4	Homo sapiens	Q9HA82	Y2H Prey Pooling	32296183
Intra	FATE1	Q969F0	CERS4	Homo sapiens	Q9HA82	Validated Y2H	32296183
Intra	FATE1	Q969F0	CERS4	Homo sapiens	Q9HA82	Y2H Array	32296183
Intra	FATE1	Q969F0	LNPEP	Homo sapiens	Q9UIQ6	Validated Y2H	25416956
Intra	FATE1	Q969F0	SMIM14	Homo sapiens	Q96QK8	Validated Y2H	32296183
Intra	FATE1	Q969F0	SMIM14	Homo sapiens	Q96QK8	Y2H	21516116
Intra	FATE1	Q969F0	UNC93B1	Homo sapiens	Q9H1C4	Validated Y2H	32296183
Intra	FATE1	Q969F0	FRMD8	Homo sapiens	Q9BZ67	Validated Y2H	32296183
Intra	FATE1	Q969F0	GIMAP5	Homo sapiens	Q96F15	Validated Y2H	32296183
Intra	FATE1	Q969F0	TIMMDC1	Homo sapiens	Q9NPL8	Y2H Array	31515488
Intra	FATE1	Q969F0	TIMMDC1	Homo sapiens	Q9NPL8	Y2H Prey Pooling	25416956
Intra	FATE1	Q969F0	TIMMDC1	Homo sapiens	Q9NPL8	Validated Y2H	25416956
Intra	FATE1	Q969F0	SYNGR1	Homo sapiens	O43759	Y2H Array	25416956
Intra	FATE1	Q969F0	SYNGR1	Homo sapiens	O43759	Validated Y2H	25416956
Intra	FATE1	Q969F0	CCDC70	Homo sapiens	Q6NSX1	Y2H Array	31515488
Intra	FATE1	Q969F0	CCDC70	Homo sapiens	Q6NSX1	Y2H Array	25416956
Intra	FATE1	Q969F0	BIK	Homo sapiens	Q13323	Y2H Array	25416956
Intra	FATE1	Q969F0	BIK	Homo sapiens	Q13323	Y2H Array	31515488
Intra	FATE1	Q969F0	BIK	Homo sapiens	Q13323	Y2H Prey Pooling	25416956
Intra	FATE1	Q969F0	BIK	Homo sapiens	Q13323	Validated Y2H	25416956
Intra	FATE1	Q969F0	BCL2L2	Homo sapiens	Q92843	Y2H Prey Pooling	25416956
Intra	FATE1	Q969F0	BCL2L2	Homo sapiens	Q92843	Validated Y2H	25416956
Intra	FATE1	Q969F0	SYNE4	Homo sapiens	Q8N205	Validated Y2H	25416956
Intra	FATE1	Q969F0	SYNE4	Homo sapiens	Q8N205	Y2H Array	25416956
Intra	FATE1	Q969F0	PIN4	Homo sapiens	Q9Y237	Y2H Prey Pooling	25416956
Intra	FATE1	Q969F0	PIN4	Homo sapiens	Q9Y237	Y2H Array	25416956
Intra	FATE1	Q969F0	TMEM11	Homo sapiens	P17152	Y2H	21516116
Intra	FATE1	Q969F0	SYNDIG1	Homo sapiens	Q9H7V2	Y2H Prey Pooling	25416956
Intra	FATE1	Q969F0	SYNDIG1	Homo sapiens	Q9H7V2	Validated Y2H	32296183
Intra	FATE1	Q969F0	SYNDIG1	Homo sapiens	Q9H7V2	Validated Y2H	25416956
Intra	FATE1	Q969F0	AGTRAP	Homo sapiens	Q6RW13	Y2H Array	25416956
Intra	FATE1	Q969F0	SEC23B	Homo sapiens	Q15437	Y2H Array	25416956
Intra	FATE1	Q969F0	RNF183	Homo sapiens	Q96D59	Validated Y2H	32296183
Intra	FATE1	Q969F0	RNF183	Homo sapiens	Q96D59	Y2H Pooling	16189514
Intra	FATE1	Q969F0	DCTN5	Homo sapiens	Q9BTE1	Y2H Prey Pooling	25416956
Intra	FATE1	Q969F0	DCTN5	Homo sapiens	Q9BTE1	Y2H Array	25416956
Intra	FATE1	Q969F0	DCTN5	Homo sapiens	Q9BTE1	Validated Y2H	25416956
Intra	FATE1	Q969F0	ZCCHC12	Homo sapiens	Q6PEW1	Y2H Prey Pooling	32296183
Intra	FATE1	Q969F0	ZCCHC12	Homo sapiens	Q6PEW1	Y2H Array	32296183
Intra	FATE1	Q969F0	INPP5K	Homo sapiens	Q9BT40	Validated Y2H	32296183
Intra	FATE1	Q969F0	INPP5K	Homo sapiens	Q9BT40	Validated Y2H	25416956
Intra	FATE1	Q969F0	INPP5K	Homo sapiens	Q9BT40	Y2H Array	29892012
Intra	FATE1	Q969F0	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	25416956
Intra	FATE1	Q969F0	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	32296183
Intra	FATE1	Q969F0	KASH5	Homo sapiens	Q8N6L0	Y2H Array	32296183
Intra	FATE1	Q969F0	BNIP3	Homo sapiens	Q12983	Y2H Prey Pooling	25416956
Intra	FATE1	Q969F0	YIPF4	Homo sapiens	Q9BSR8	Validated Y2H	25416956
Intra	FATE1	Q969F0	YIPF4	Homo sapiens	Q9BSR8	Validated Y2H	32296183
Intra	FATE1	Q969F0	YIPF4	Homo sapiens	Q9BSR8	Y2H Array	25416956
Intra	FATE1	Q969F0	BNIP2	Homo sapiens	Q12982	Validated Y2H	32296183
Intra	FATE1	Q969F0	BNIP2	Homo sapiens	Q12982	Y2H Array	25416956
Intra	FATE1	Q969F0	BNIP2	Homo sapiens	Q12982	Y2H Prey Pooling	25416956
Intra	FATE1	Q969F0	BNIP2	Homo sapiens	Q12982	Validated Y2H	25416956
Intra	FATE1	Q969F0	TRAF3IP3	Homo sapiens	Q9Y228	Validated Y2H	32296183
Intra	FATE1	Q969F0	TRAF3IP3	Homo sapiens	Q9Y228	Y2H Array	25416956
Intra	FATE1	Q969F0	TRAF3IP3	Homo sapiens	Q9Y228	Y2H Prey Pooling	25416956
Intra	FATE1	Q969F0	BNIP3L	Homo sapiens	O60238	Y2H Prey Pooling	25416956
Intra	FATE1	Q969F0	CREB3L3	Homo sapiens	Q68CJ9	Y2H Prey Pooling	32296183
Intra	FATE1	Q969F0	CREB3L3	Homo sapiens	Q68CJ9	Y2H Array	32296183
Intra	FATE1	Q969F0	NRG4	Homo sapiens	Q8WWG1	Y2H Array	25416956
Intra	FATE1	Q969F0	NRG4	Homo sapiens	Q8WWG1	Y2H Prey Pooling	25416956
Intra	FATE1	Q969F0	DNAJC30	Homo sapiens	Q96LL9	Validated Y2H	32296183
Intra	FATE1	Q969F0	TM4SF4	Homo sapiens	P48230	Validated Y2H	25416956
Intra	FATE1	Q969F0	SEC22A	Homo sapiens	Q96IW7	Y2H Prey Pooling	25416956
Intra	FATE1	Q969F0	SEC22A	Homo sapiens	Q96IW7	Validated Y2H	32296183
Intra	FATE1	Q969F0	VSIG4	Homo sapiens	Q9Y279	Validated Y2H	32296183
Intra	FATE1	Q969F0	SLC38A1	Homo sapiens	Q9H2H9	Validated Y2H	32296183
Intra	FATE1	Q969F0	SLC38A1	Homo sapiens	Q9H2H9	Y2H Array	25416956
Cross	FATE1	Q969F0	tax	Human T-cell leukemia virus 1	P14079	MAPPIT	22458338

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Martin-Probst Syndrome	Deafness-Intellectual Disability, Martin-Probst Type Syndrome Martin-Probst Deafness-Mental Retardation Syndrome Mental Retardation, X-Linked, Syndromic, Martin-Probst Type MRXSMP Deafness-Intellectual Disability Syndrome, Martin-Probst Type Hearing Loss-Intellectual Disability Syndrome, Martin-Probst Type X-Linked Deafness-Intellectual Disability Syndrome Syndrome X-Linked Hearing Loss-Intellectual Disability Syndrome Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04764	FATE1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22500	Fate1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	FATE1	VGNC	VGNC:28878
Felis catus	FATE1	VGNC	VGNC:62160
Mus musculus	FATE1	MGD	MGI:1925155
Canis familiaris	FATE1	VGNC	VGNC:40746
Others	FATE1	NCBI