MR1 - major histocompatibility complex, class I-related Gene

Also Known as HLALS

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3140

About MR1

Cytogenetic location: 1q25.3 Genomic coordinates (GRCh38): 1:181,033,387-181,061,938 (from NCBI)

This gene has 12 transcripts (splice variants), 649 orthologues and 22 paralogues. Ubiquitous expression in urinary bladder (RPKM 6.3), thyroid (RPKM 5.6) and 24 other tissues.

Summary

MAIT (mucosal-associated invariant T-cells) lymphocytes represent a small population of T-cells primarily found in the gut. The protein encoded by this gene is an antigen-presenting molecule that presents metabolites of microbial vitamin B to MAITs. This presentation may activate the MAITs to regulate the amounts of specific types of bacteria in the gut. Several transcript variants encoding different isoforms have been found for this gene, and a pseudogene of it has been detected about 36 kbp upstream on the same chromosome. [provided by RefSeq, Jul 2015]

MR1 Products (9)

mRNA Protein Name
NM_001194999.2 NP_001181928.1 major histocompatibility complex class I-related gene protein isoform 2 precursor
NM_001195000.2 NP_001181929.1 major histocompatibility complex class I-related gene protein isoform 3 precursor
NM_001195035.2 NP_001181964.1 major histocompatibility complex class I-related gene protein isoform 4 precursor
NM_001310213.2 NP_001297142.1 major histocompatibility complex class I-related gene protein isoform 5
NM_001385161.1 NP_001372090.1 major histocompatibility complex class I-related gene protein isoform 1 precursor
NM_001385162.1 NP_001372091.1 major histocompatibility complex class I-related gene protein isoform 6 precursor
NM_001385163.1 NP_001372092.1 major histocompatibility complex class I-related gene protein isoform 7 precursor
NM_001385164.1 NP_001372093.1 major histocompatibility complex class I-related gene protein isoform 3 precursor
NM_001531.3 NP_001522.1 major histocompatibility complex class I-related gene protein isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables T cell receptor binding IDA
IDA: Inferred from direct assay
26795251 GOA
enables beta-2-microglobulin binding IDA
IDA: Inferred from direct assay
26795251 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23051753 GOA
Biological Process GO Annotation Evidence Références Source
involved in antigen processing and presentation of exogenous antigen IDA
IDA: Inferred from direct assay
27043408 GOA
involved in defense response to Gram-negative bacterium IDA
IDA: Inferred from direct assay
20581831 GOA
involved in defense response to Gram-positive bacterium IDA
IDA: Inferred from direct assay
27527800 GOA
involved in positive regulation of T cell mediated cytotoxicity directed against tumor cell target IDA
IDA: Inferred from direct assay
31959982 GOA
Cellular Component GO Annotation Evidence Références Source
located in early endosome membrane IDA
IDA: Inferred from direct assay
27043408 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
21190736 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
27043408 GOA
located in late endosome membrane IDA
IDA: Inferred from direct assay
27043408 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
27043408 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MR1 Protein Structure

MHC_I

MHC_I: Class I Histocompatibility antigen, domains alpha 1 and 2 (24 - 198)

C1-set

C1-set: Immunoglobulin C1-set domain (218 - 286)

  • 0
  • 100
  • 200
  • 300
  • 341 a.a.
Protein Preferred Names Protein Names

major histocompatibility complex class I-related gene protein

  • MHC class I-like antigen MR-1

MR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
MR1 Q95460 FATE1 Homo sapiens Q969F0
Y2H Array
25416956
Intra
MR1 Q95460 FATE1 Homo sapiens Q969F0
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

MR1 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P84718 MR1 Antibody (YA4415) IHC-P, ICC/IF, FC, ELISA Human
HY-P84718A MR1 Antibody (YA4415)(PBS only) IHC-P, ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Immune Deficiency Disease

  • Immunodeficiency

  • Primary Immunodeficiency

  • Primary Immunodeficiency Disease

  • Immunologic Deficiency Syndromes

  • Hypoimmunity

  • Immune Deficiency Disorder

  • Immunodeficiency Syndrome

  • Immune Disorder

  • Primary Immune Deficiency Disorder

  • Immune System Diseases

  • Human Immunodeficiency Virus Infection

  • Hiv - [Human Immunodeficiency Virus Infection]

  • Hiv Positive Nos

  • Hiv Disease

  • Acquired Immune Deficiency Syndrome-Related Complex

  • Aids-Like Syndrome

  • Aids-Related Complex Nos

  • Arc - [Aids-Related Complex]

  • Immunodeficiency Due To Human Immunodeficiency Virus Infection

  • Unspecified Human Immunodeficiency Virus Disease

  • Hiv Disease Nos

  • Human Immunodeficiency Virus Positive Nos

  • Hiv Nos

  • Deficiency Of Complement Initial Pathway

  • Deficiency Of Complement Terminal Pathway

  • Cfdd - [Complement Factor D Deficiency]

  • Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

  • Nonfamilial Hypogammaglobulinaemia

  • Common Variable Immune Deficiency

  • Nonfamilial Agammaglobulinaemia

  • Common Variable Agammaglobulinaemia

  • Agammaglobulinaemia Nos

  • Agammaglobulinaemia Antibody Deficiency Syndrome

  • Hypogammaglobulinaemia Antibody Deficiency Syndrome

  • Acquired Agammaglobulinaemia Nos

  • Hypogammaglobulinaemia Nos

  • Hyper Igm
Hemochromatosis, Type 1

  • Hemochromatosis

  • Hemochromatosis Type 1

  • Hereditary Hemochromatosis

  • Hh

  • HFE1

  • Hfe Hemochromatosis, Modifier Of

  • Symptomatic Form Of Classic Hemochromatosis

  • Symptomatic Form Of Hemochromatosis Type 1

  • Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis

  • Haemochromatosis

  • Iron Storage Disorder

  • Bronze Diabetes

  • Hereditary Haemochromatosis

  • Hlah

  • Hfe

  • Hemochromatosis, Hereditary

  • Diabetes Bronze

  • Classic Hemochromatosis

  • Hfe-Associated Hereditary Hemochromatosis

  • Hemochromatosis Classic

  • Bronzed Cirrhosis

  • Familial Hemochromatosis

  • Genetic Hemochromatosis

  • Hc

  • Pigmentary Cirrhosis

  • Primary Hemochromatosis

  • Troisier-Hanot-Chauffard Syndrome

  • Von Recklenhausen-Applebaum Disease

  • Hemochromatosis 1

  • Primary Hereditary Hemochromatosis

  • Bronze Cirrhosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit Effect
Pureté Phase
HY-157282 Photolumazine I / Phase 4

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-124004 Acetyl-6-formylpterin 95.0% Unkown
HY-126855 Cholic acid 7-sulfate 99.92% Unkown
HY-32955 2-Chloropyridine-5-boronic acid 99.96% Unkown
HY-W168754 DB28 Inhibitor 99.92% Unkown
HY-157281 Photolumazine III 99.96% Unkown
HY-157194 RL-6-Me-7-OH 96.56% Unkown
HY-182894 MR1-114 Inhibitor / Unkown
HY-P11249 Mr1.1[S4Dap, C16Pen] Inhibitor / Unkown
HY-RS08637 MR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10777 PNKD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-126855S Cholic acid 7-sulfate-d4 / Unkown
HY-163122 5-Formylsalicylic acid 99.54% Unkown
Inhibitory Antibodies (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-P990134 Anti-Mouse CD40L/CD154 Antibody (MR-1) Inhibitor 99.62% Unkown
HY-P990269 Anti-Mouse CD40L/CD154 (LALA-PG) Antibody (MR-1) Inhibitor 95.00% Unkown
HY-P990270 Anti-Mouse CD40L/CD154 (D265A) Antibody (MR-1) / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MR1 VGNC VGNC:100013
Mus musculus MR1 MGD MGI:1195463
Bos taurus MR1 VGNC VGNC:31595
Rattus norvegicus MR1 RGD RGD:1593291
Others MR1 NCBI