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Cat. No.: HY-P11249

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Mr1.1[S4Dap, C16Pen]

Mr1.1[S4Dap, C16Pen] is a highly active and selective nAChR (human α9α10 nAChR IC₅₀ = 4.0 nM, rat α9α10 nAChR IC₅₀ = 2.7 nM) inhibitor. Mr1.1[S4Dap, C16Pen] can significantly relieve pain and has significant stability. Mr1.1[S4Dap, C16Pen] can be used for the study of neuropathic pain.

For research use only. We do not sell to patients.

Formula: C₇₁H₁₀₉N₂₅O₂₂S₄
Molecular Weight:1793.04

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Mr1.1[S4Dap, C16Pen] Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Chemical Information

Molecular Weight 1793.04
Formula C₇₁H₁₀₉N₂₅O₂₂S₄
Sequence

Gly-Cys-Cys-{Dap}-His-Pro-Ala-Cys-Ser-Val-Asn-Asn-Pro-Asp-Ile-{Pen}-NH2 (Disulfide bridge: Cys2-Cys8,Cys3-Pen)
Sequence Shortening

GCC-{Dap}-HPACSVNNPDI-{Pen}-NH2 (Disulfide bridge: Cys2-Cys8,Cys3-Pen)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (258 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li T, et al. Development of an Intravenously Stable Disulfide-Rich Peptide for the Treatment of Chemotherapy-Induced Neuropathic Pain. J Med Chem. 2024 Nov 14;67(21):18741-18752. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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