2. Apoptosis Immunology/Inflammation
  3. TNF Receptor IFNAR
  4. Anti-Mouse CD40L/CD154 Antibody (MR-1)

Anti-Mouse CD40L/CD154 Antibody (MR-1) 

Cat. No.: HY-P990134 Purity: 99.62%
COA
SDS
Technical Support

Anti-Mouse CD40L/CD154 Antibody (MR-1) is an anti-mouse CD40L/CD154 IgG monoclonal antibody. Anti-Mouse CD40L/CD154 Antibody (MR-1) reduces the expression of IFN signaling pathway and lowers the level of IFN-β. Anti-Mouse CD40L/CD154 Antibody (MR-1) can prolong the survival time of transplants. Anti-Mouse CD40L/CD154 Antibody (MR-1) can be used for researches on cancer, inflammation conditions and xenotransplantation such as pancreatic cancer and autoimmune cholangitis.

For research use only. We do not sell to patients.

Size Price Stock Quantity
1 mg In-stock
5 mg In-stock
10 mg In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 Customer Validation

Anti-Mouse CD40L/CD154 Antibody (MR-1) Featured Recommendations:

Anti-Mouse CD40L/CD154 Antibody (MR-1) Related Antibodies

Top Publications Citing Use of Products

View All TNF Receptor Isoform Specific Products:

View All Isoforms
TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Anti-Mouse CD40L/CD154 Antibody (MR-1) is an anti-mouse CD40L/CD154 IgG monoclonal antibody. Anti-Mouse CD40L/CD154 Antibody (MR-1) reduces the expression of IFN signaling pathway and lowers the level of IFN-β. Anti-Mouse CD40L/CD154 Antibody (MR-1) can prolong the survival time of transplants. Anti-Mouse CD40L/CD154 Antibody (MR-1) can be used for researches on cancer, inflammation conditions and xenotransplantation such as pancreatic cancer and autoimmune cholangitis[1][2][3].

Isotype

Armenian hamster IgG
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target

CD40L/CD154
In Vitro

Anti-Mouse CD40L/CD154 Antibody (MR-1) (200 μg/mL, 48 h) significantly inhibits the production of IFN-β in natural killer T (NKT) cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD40L/CD154 Antibody (MR-1) Related Antibodies

ELISA Assay[1]

Cell Line: NKT cells, co-cultivation with peritoneal macrophages
Concentration: 200 μg/mL
Incubation Time: 48 h
Result: Reduced the level of IFN-β.
In Vivo

Anti-Mouse CD40L/CD154 Antibody (MR-1) (500 μg, i.p., once every 2 days, from 2 days before tumor inoculation to 12 days after inoculation) significantly reduces the expression of type I IFN signaling pathway related genes in male C57BL/6J mice bearing KPC1242 tumors[1].
Anti-Mouse CD40L/CD154 Antibody (MR-1) (20 mg/kg, i.p., once daily for 4 days at 1 day before surgery, once a week until the end of the experiment) extends the survival time of human neural stem cells (hNSCs) in 5XFAD transgenic mice[2].
Anti-Mouse CD40L/CD154 Antibody (MR-1) (25 mg/kg, i.p., on day 0, 2, 4 and 7 for initial stage, once weekly for maintenance stage) can temporarily delay the progression of cholangitis in dnTGFβRII mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 1×104 KPC1242 cells injected male C57BL/6J mice (8-12 weeks)[1]
Dosage: 500 μg
Administration: Intraperitoneal injection (i.p.), once every 2 days, from 2 days before tumor inoculation to 12 days after inoculation
Result: Significantly reduced the expression of IFN signaling pathway.
Animal Model: 5XFAD transgenic mice[2]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection (i.p.), once daily for 4 days at 1 day before surgery, once a week until the end of the experiment
Result: Extended the survival time of hNSCs to 34 weeks.
Significantly suppressed transplant rejection reaction.
Animal Model: dnTGFβRII mice (3-4 weeks)[3]
Dosage: 25 mg/kg
Administration: Intraperitoneal injection (i.p.), on day 0, 2, 4 and 7 for initial stage, once weekly for maintenance stage
Result: Significantly reduced portal vein inflammation and bile duct injury scores for short-term treatment.
Reduced intrahepatic NKT cells and effector T cells in short-term treatment.
Reduced the levels of IFN-γ, IL-4 and IL-17A for short-term treatment.
Gene ID

21947  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse CD40L/CD154 Antibody (MR-1)]
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
  • Clinical disease scores of mice with active intestinal inflammation and upon Anti-Mouse CD40L/CD154 Antibody (MR-1, HY-P990134) remission in colitis.
  • Histopathological scores of naive mice, mice with active disease, or Anti-Mouse CD40L/CD154 Antibody (MR-1, HY-P990134) in colitis.
Purity & Documentation

Purity: 99.62%

SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (603 KB)
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Anti-Mouse CD40L/CD154 Antibody (MR-1) Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD40L/CD154 Antibody (MR-1)TNF ReceptorIFNARTumor Necrosis Factor ReceptorTNFRInterferon-α/β receptorInterferon-alpha/beta receptorCD40L/CD154IFNtransplantsKPC1242Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Anti-Mouse CD40L/CD154 Antibody (MR-1)
Cat. No.:
HY-P990134
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (251 KB) Français - FR (251 KB) Deutsch - DE (251 KB) Norwegian - NO (251 KB) Español - ES (251 KB) Swedish - SV (251 KB) Italian - IT (251 KB) Korean - KR (251 KB) Portuguese - PT (251 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.