Cd40lg - CD40 ligand Gene

Also Known as IGM; IMD3; Ly62; TRAP; gp39; CD154; Cd40l; HIGM1; Ly-62; T-BAM; CD40-L; Tnfsf5; Tnlg8b

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21947

Summary

Predicted to enable CD40 receptor binding activity and Integrin binding activity. Involved in isotype switching. Acts upstream of or within B cell differentiation and regulation of immunoglobulin production. Located in external side of plasma membrane. Is expressed in Meckel's cartilage; dorsal root ganglion; and limb. Used to study inflammatory bowel disease and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; artery disease (multiple); autoimmune disease (multiple); combined T cell and B cell immunodeficiency (multiple); and hematologic Cancer (multiple). Orthologous to human CD40LG (CD40 ligand). [provided by Alliance of Genome Resources, Apr 2022]

Cd40lg Products (1)

mRNA Protein Name
NM_011616.3 NP_035746.2 CD40 ligand

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell differentiation IGI
IGI: Inferred from genetic interaction
14647274 MGI
acts upstream of or within immunoglobulin production IGI
IGI: Inferred from genetic interaction
15485634 MGI
involved in isotype switching IDA
IDA: Inferred from direct assay
7529792 MGI
acts upstream of or within regulation of immunoglobulin production IDA
IDA: Inferred from direct assay
12958312 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
17082577 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

CD40 ligand

  • T-cell antigen Gp39

  • TNF-related activation protein

  • tumor necrosis factor ligand 8b

  • tumor necrosis factor ligand superfamily member 5

Recombinant Cd40lg Proteins

Cat. No. Product Name Accession Purity
HY-P70808 CD40L/CD154/TRAP Protein, Mouse (HEK293, His) P27548 (M112-L260) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72908 CD40L/CD154/TRAP Protein, Mouse (HEK293, Fc) P27548 (G115-L260) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P78271 CD40L/CD154/TRAP Trimer Protein, Mouse (HEK293, Fc) P27548 (M112-L260) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02247 CD40LG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174737 Human CD40LG mRNA / Unkown
HY-RS17669 Cd40lg Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24130 Cd40lg Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd40lg NCBI NCBI:959