Cat. No.: HY-126855

Cholic acid 7-sulfate

(Synonyms: 7-Sulfocholic acid)

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

Cholic acid 7-sulfate (7-Sulfocholic acid) is a selective agonist targeting TGR5 (EC₅₀=0.17 μM) and a ligand for MHC class I-related protein (MR1). As a gut-restricted TGR5 agonist, cholic acid 7-sulfate binds to TGR5 on enteroendocrine L cells, induces GLP-1 secretion, and improves glucose tolerance in a TGR5-dependent manner. Cholic acid 7-sulfate also acts as an endogenous ligand for MR1, promoting the survival of mucosal-associated invariant T cells MAIT and the expression of homeostatic gene signatures, affecting MAIT cell development and function. Cholic acid 7-sulfate is mainly used in the research of diabetes and MAIT cell-related immune regulation.

For research use only. We do not sell to patients.

Purity: 99.92%
CAS No.: 60320-05-0
Formula: C₂₄H₄₀O₈S
Molecular Weight:488.63

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Cholic acid 7-sulfate Chemical Structure

CAS No.: 60320-05-0

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

TGR^[1]

All MHC Isoforms :

MHC I
MHC II

In Vitro

Cholic acid 7-sulfate activates human TGR5 in a dose-dependent manner and induces GLP-1 secretion from NCI-H716 cells (EC₅₀=0.17 μM), and this effect can be inhibited by TGR5 siRNA knockdown^[1].
Cholic acid 7-sulfate (1 mM; 6 d) promotes MAIT cell survival and induces CXCR4 and IL7R expression when stimulated with human PBMCs, without causing cell proliferation or CD69 upregulation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

PBMCs
Concentration:

1 mM
Incubation Time:

6 days
Result:

Promotes MAIT cell survival.

In Vivo

Cholic acid 7-sulfate (1 mg; enteral administration; single dose; 15 min) increases circulating GLP-1 levels, decreases blood glucose, and increases insulin in diet-induced obese (DIO) mice, while inducing colonic Tgr5 gene expression^[1]. Cholic acid 7-sulfate (100 mg/kg; oral gavage; single dose; 5 h) improves glucose tolerance and increases circulating GLP-1 in DIO mice, and the glucose clearance effect is dependent on TGR5^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 60320-05-0
Appearance Solid
Molecular Weight 488.63
Formula C₂₄H₄₀O₈S
Color White to off-white
SMILES

C[C@H](CCC(O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@H](OS(=O)(O)=O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@]12C
Synonyms

7-Sulfocholic acid
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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SSRN

2025 Jul 10.

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (204.65 mM)

DMF : 1 mg/mL (2.05 mM; Need ultrasonic and warming)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.0465 mL

10.2327 mL

20.4654 mL

5 mM

0.4093 mL

2.0465 mL

4.0931 mL

10 mM

0.2047 mL

1.0233 mL

2.0465 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chaudhari SN, et, al. Bariatric surgery reveals a gut-restricted TGR5 agonist with anti-diabetic effects. Nat Chem Biol. 2021 Jan;17(1):20-29. [Content Brief]

[2]. Ito E, et al. Sulfated bile acid is a host-derived ligand for MAIT cells. Sci Immunol. 2024 Jan 26;9(91):eade6924. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMF / H₂O	1 mM	2.0465 mL	10.2327 mL	20.4654 mL	51.1635 mL
H₂O	5 mM	0.4093 mL	2.0465 mL	4.0931 mL	10.2327 mL
	10 mM	0.2047 mL	1.0233 mL	2.0465 mL	5.1163 mL
	15 mM	0.1364 mL	0.6822 mL	1.3644 mL	3.4109 mL
	20 mM	0.1023 mL	0.5116 mL	1.0233 mL	2.5582 mL
	25 mM	0.0819 mL	0.4093 mL	0.8186 mL	2.0465 mL
	30 mM	0.0682 mL	0.3411 mL	0.6822 mL	1.7054 mL
	40 mM	0.0512 mL	0.2558 mL	0.5116 mL	1.2791 mL
	50 mM	0.0409 mL	0.2047 mL	0.4093 mL	1.0233 mL
	60 mM	0.0341 mL	0.1705 mL	0.3411 mL	0.8527 mL
	80 mM	0.0256 mL	0.1279 mL	0.2558 mL	0.6395 mL
	100 mM	0.0205 mL	0.1023 mL	0.2047 mL	0.5116 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Cholic acid 7-sulfate

1 Cited Publications

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Cholic acid 7-sulfate

Bioactive Compound Library Max

Bioactive Compound Library

GPCR/G Protein Compound Library

Immunology/Inflammation Compound Library

Anti-diabetic Compound Library

Lipid Compound Library

Anti-Obesity Compound Library

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Mass Spectrometry Human Metabolite Library

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Publications Citing Use of MedChemExpress (MCE) Cholic acid 7-sulfate

All MHC Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Cholic acid 7-sulfate

Bioactive Compound Library Max

Bioactive Compound Library

GPCR/G Protein Compound Library

Immunology/Inflammation Compound Library

Anti-diabetic Compound Library

Lipid Compound Library

Anti-Obesity Compound Library

Food-Sourced Compound Library

Human Metabolite Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Highly Selective Activators Library

MCE Bioactive Compound Library

Fatty Acids Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) Cholic acid 7-sulfate

All MHC Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Cholic acid 7-sulfate Related Classifications

HY-126855 Related Classifications