1. GPCR/G Protein
  2. GPCR19
  3. SB756050

SB756050 

Cat. No.: HY-102016 Purity: 99.32%
Handling Instructions

SB756050 is a selective TGR5 agonist. SB756050 has the potential for type 2 diabetes treatment.

For research use only. We do not sell to patients.

SB756050 Chemical Structure

SB756050 Chemical Structure

CAS No. : 447410-57-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 83 In-stock
Estimated Time of Arrival: December 31
10 mg USD 75 In-stock
Estimated Time of Arrival: December 31
25 mg USD 135 In-stock
Estimated Time of Arrival: December 31
50 mg USD 220 In-stock
Estimated Time of Arrival: December 31
100 mg USD 350 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products

    SB756050 purchased from MCE. Usage Cited in: Cell Death Discov. 2020 Jul 6.

    GES-1 cells are treated with SB756050 (2, 5, and 10 μM) for 24 h. KLF4 and CDX2 protein expression is examined by WB. The results show that KLF4 and CDX2 expression is significantly increased.
    • Biological Activity

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    • References

    • Customer Review

    Description

    SB756050 is a selective TGR5 agonist. SB756050 has the potential for type 2 diabetes treatment.

    In Vitro

    TGR5 is a bile acid receptor and a potential target for the treatment of type 2 diabetes (T2D)[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    SB756050 is well‐tolerated; it is readily absorbed, exhibited nonlinear pharmacokinetics with a less than dose‐proportional increase in plasma exposure above 100 mg, and demonstrates no significant changes in exposure when co‐administered with sitagliptin. SB756050 demonstrates highly variable pharmacodynamic effects both within dose groups and between doses, with increases in glucose seen at the two lowest doses and no reduction in glucose seen at the two highest doses. The glucose effects of SB756050 sitagliptin are comparable to those of sitagliptin alone, even though gut hormone plasma profiles are different[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight

    500.59

    Formula

    C₂₁H₂₈N₂O₈S₂

    CAS No.

    447410-57-3

    SMILES

    O=S(N1CCN(S(=O)(C2=CC=C(OC)C(OC)=C2)=O)CCC1)(C3=CC=C(OC)C(OC)=C3)=O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 150 mg/mL (299.65 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9976 mL 9.9882 mL 19.9764 mL
    5 mM 0.3995 mL 1.9976 mL 3.9953 mL
    10 mM 0.1998 mL 0.9988 mL 1.9976 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
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    Keywords:

    SB756050SB 756050SB-756050GPCR19G-protein coupled receptor 19Inhibitorinhibitorinhibit

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    Product Name:
    SB756050
    Cat. No.:
    HY-102016
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