2. Metabolic Enzyme/Protease
  3. FXR
  4. Tauro-β-muricholic acid sodium

Tauro-β-muricholic acid sodium  (Synonyms: T-βMCA sodium)

Cat. No.: HY-135103 Purity: 98.60%
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Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite, is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC50 of 40 μM.

For research use only. We do not sell to patients.

Tauro-β-muricholic acid sodium Chemical Structure

Tauro-β-muricholic acid sodium Chemical Structure

CAS No. : 145022-92-0

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Based on 1 publication(s) in Google Scholar

Other Forms of Tauro-β-muricholic acid sodium:

Tauro-β-muricholic acid sodium Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Tauro-β-muricholic acid sodium

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite, is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC50 of 40 μM[1][2][3].

IC50 & Target

IC50: 40 μM (FXR)[1]
In Vitro

T-βMCA sodium inhibits FXR reporter activity in the CRC cell line HT29 (EC50 ~10 μM)[3].
T-βMCA sodium dose-dependently increases WNT signaling in HT29 and HCT116 cells[3].
T-βMCA sodium induces proliferation and DNA damage in Lgr5+ cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tauro-β-muricholic acid sodium Related Antibodies
In Vivo

T-βMCA sodium (400 mg/kg; i.g.; twice a week; for 6 weeks) can effectively recapitulate the ability of HFD to promote CRC progression[3].
T-βMCA sodium treatment also significantly increases levels of serum cytokines, including IFN-γ, IL-6, and IL-17[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: APCmin/+ mice[3]
Dosage: 400 mg/kg
Administration: Oral gavage; twice a week; for 6 weeks
Result: Markedly decreased intestinal integrity and accelerated tumor growth in the intestine and colon.
Molecular Weight

537.68

Formula

C26H44NNaO7S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]([C@]1([H])[C@H](O)[C@@H]2O)(CC[C@@H](O)C1)[C@]3([H])[C@]2([H])[C@@](CC[C@]4([H])[C@H](C)CCC(NCCS(=O)(O[Na])=O)=O)([H])[C@]4(C)CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (18.60 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8598 mL 9.2992 mL 18.5984 mL
5 mM 0.3720 mL 1.8598 mL 3.7197 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.60%

COA (250 KB) HNMR (225 KB) RP-HPLC (265 KB) MS (72 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8598 mL 9.2992 mL 18.5984 mL 46.4961 mL
5 mM 0.3720 mL 1.8598 mL 3.7197 mL 9.2992 mL
10 mM 0.1860 mL 0.9299 mL 1.8598 mL 4.6496 mL
15 mM 0.1240 mL 0.6199 mL 1.2399 mL 3.0997 mL
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Tauro-β-muricholic acid sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tauro-β-muricholic acid145022-92-0T-βMCAFXRNR1H4BileacidcolorectalcancerCRCInhibitorinhibitorinhibit

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