1. Metabolic Enzyme/Protease
  2. FXR
  3. NDB

NDB 

Cat. No.: HY-138937
Handling Instructions

NDB is a selective human FXRα (hFXRα) antagonist that is effective in modulating transcription of FXRα downstream genes. NDB can be used in anti-diabetes research.

For research use only. We do not sell to patients.

NDB Chemical Structure

NDB Chemical Structure

CAS No. : 1660153-08-1

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Description

NDB is a selective human FXRα (hFXRα) antagonist that is effective in modulating transcription of FXRα downstream genes. NDB can be used in anti-diabetes research[1].

IC50 & Target

Human FXRα (hFXRα)[1]

In Vitro

NDB induces rearrangements of helix 11 (H11) and helix 12 (H12, AF-2) by forming a homodimer of hFXRα-LBD, totally different from the active conformation in monomer state[1].
NDB (25 μM) effectively antagonizes the GW4064-stimulated FXR/RXR interaction and FXRα target gene expression in primary mouse hepatocytes, including the small heterodimer partner (SHP) and bile-salt export pump (BSEP)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NDB (24 mg/kg; intraperitoneal injection; once a day; for 4 weeks) efficiently decreases the gene expressions of phosphoenolpyruvate carboxykinase (PEPCK), glucose 6-phosphatase (G6-pase), small heterodimer partner, and BSEP in db/db mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J db/db mice (8 weeks of age)[1]
Dosage: 24 mg/kg
Administration: Intraperitoneal injection; once a day; for 4 weeks
Result: Decreased the gene expressions of PEPCK, G6-pase, small heterodimer partner, and BSEP.
Molecular Weight

471.42

Formula

C26H28Cl2N2O2

CAS No.
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NDB
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