Taurohyocholic acid sodium salt
Based on 1 Customer Validation
Taurohyocholic acid (THCA) sodium salt is a taurine-conjugated hyocholic acid. Taurohyocholic acid sodium salt is predictor of the efficacy of tyrosine kinase inhibitors combined withPD-1 inhibitors in hepatocellular carcinoma (HCC).
For research use only. We do not sell to patients.
- Purity: 98.08%
- CAS No.: 117997-17-8
- Formula: C26H44NNaO7S
- Molecular Weight:537.68
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All Endogenous Metabolite Isoforms
More
Biological Activity
Description
Chemical Information
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CAS No. 117997-17-8
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Appearance Solid
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Molecular Weight 537.68
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Formula C26H44NNaO7S
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Color White to off-white
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SMILES
C[C@@]12[C@]3([H])[C@]([C@@H]([C@@H]([C@]1([H])C[C@@H](CC2)O)O)O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)CCC(NCCS(=O)(O[Na])=O)=O)C
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Synonyms
THCA sodium salt
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
H2O : ≥ 100 mg/mL (185.98 mM)
DMSO : 20 mg/mL (37.20 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. He J, et al. Semi-Preparative Isolation and Purification of Three Tauro-Conjugated Cholic Acids from Pulvis Fellis Suis by HSCCC Coupled with ELSD Detection. Chromatographia. 2011;73(3-4):361-365. [Content Brief]
[2]. Chen Y, et al. Taurohyocholic acid acts as a potential predictor of the efficacy of tyrosine kinase inhibitors combined with programmed cell death-1 inhibitors in hepatocellular carcinoma. Front Pharmacol. 2024 Feb 23;15:1364924. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 1.8598 mL | 9.2992 mL | 18.5984 mL | 46.4961 mL |
| 5 mM | 0.3720 mL | 1.8598 mL | 3.7197 mL | 9.2992 mL | |
| 10 mM | 0.1860 mL | 0.9299 mL | 1.8598 mL | 4.6496 mL | |
| 15 mM | 0.1240 mL | 0.6199 mL | 1.2399 mL | 3.0997 mL | |
| 20 mM | 0.0930 mL | 0.4650 mL | 0.9299 mL | 2.3248 mL | |
| 25 mM | 0.0744 mL | 0.3720 mL | 0.7439 mL | 1.8598 mL | |
| 30 mM | 0.0620 mL | 0.3100 mL | 0.6199 mL | 1.5499 mL | |
| H2O | 40 mM | 0.0465 mL | 0.2325 mL | 0.4650 mL | 1.1624 mL |
| 50 mM | 0.0372 mL | 0.1860 mL | 0.3720 mL | 0.9299 mL | |
| 60 mM | 0.0310 mL | 0.1550 mL | 0.3100 mL | 0.7749 mL | |
| 80 mM | 0.0232 mL | 0.1162 mL | 0.2325 mL | 0.5812 mL | |
| 100 mM | 0.0186 mL | 0.0930 mL | 0.1860 mL | 0.4650 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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