Tauro-α-muricholic acid sodium
Based on 2 publication(s) in Google Scholar
Tauro-α-muricholic acid sodium (T-α-MCA sodium) is a Taurine (HY-B0351)-conjugated primary Bile acid. Tauro-α-muricholic acid sodium is a FXR antagonist with an IC50 of 28 µM. Tauro-α-muricholic acid sodium attenuates other bile acid-activated FXR signaling. Tauro-α-muricholic acid sodium can be used in the research of Alzheimer's disease, glucose metabolism, and lipid metabolism.
For research use only. We do not sell to patients.
- Purity: 99.9%
- CAS No.: 2260905-08-4
- Formula: C26H44NNaO7S
- Molecular Weight:537.68
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-135103
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HY-N2027
Taurochenodeoxycholic acid -
HY-113308A
Taurolithocholic acid sodium salt -
HY-76847A
Chenodeoxycholic acid sodium -
HY-133707
β-Muricholic acid -
HY-76847
Chenodeoxycholic Acid -
HY-12222
Obeticholic acid -
HY-50108
GW 4064 -
HY-10626
T0901317 -
HY-122141
Glycohyocholic acid
Publications Citing Use of MedChemExpress (MCE) Tauro-α-muricholic acid sodium
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
Human Endogenous Metabolite |
FXR 28 μM (IC50) |
In Vitro
Tauro-α-muricholic acid sodium is a FXR antagonist with an IC50 of 28 µM. Tauro-α-muricholic acid sodium attenuates other bile acid-activated FXR signaling. Tauro-α-muricholic acid sodium can be used in the research of Alzheimer's disease, glucose metabolism, and lipid metabolism[1][2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2260905-08-4
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Appearance Solid
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Molecular Weight 537.68
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Formula C26H44NNaO7S
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Color White to off-white
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SMILES
C[C@H](CCC(NCCS(=O)(O[Na])=O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@H](O)[C@@H](O)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
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Synonyms
T-α-MCA sodium
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
J Pharm Biomed Anal
Integrating 16S rDNA sequencing analysis and targeted metabolomics to explore the mechanism of Xiexin Tang in treating atherosclerosis mice induced by high-fat diet. [Abstract]2025 Jul 15:259:116760. PMID: 40014894
Solvent & Solubility
In Vitro:
DMSO : 10 mg/mL (18.60 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Miyata M, et al. Cholesterol-lowering effects of taurine through the reduction of ileal FXR signaling due to the alteration of ileal bile acid composition. Amino Acids. 2021 Oct;53(10):1523-1532. [Content Brief]
[2]. Wu J, et al. Gender differences in the bile acid profiles of APP/PS1 transgenic AD mice. Brain Res Bull. 2020 Aug;161:116-126. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8598 mL | 9.2992 mL | 18.5984 mL | 46.4961 mL |
| 5 mM | 0.3720 mL | 1.8598 mL | 3.7197 mL | 9.2992 mL | |
| 10 mM | 0.1860 mL | 0.9299 mL | 1.8598 mL | 4.6496 mL | |
| 15 mM | 0.1240 mL | 0.6199 mL | 1.2399 mL | 3.0997 mL |
Tauro-α-muricholic acid sodium Related Classifications
HY-133890A Related Classifications
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