SYNDIG1 - synapse differentiation inducing 1 Gene

Also Known as DSPC2; IFITMD5; TMEM90B; C20orf39

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79953

About SYNDIG1

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:24,469,629-24,666,616 (from NCBI)

This gene has 2 transcripts (splice variants), 192 orthologues and 3 paralogues. Biased expression in brain (RPKM 1.9), heart (RPKM 1.6) and 11 other tissues.

Summary

This gene encodes a protein that belongs to the interferon-induced transmembrane family of proteins. A similar protein in rat is thought to regulate the development of excitatory synapses. [provided by RefSeq, Jul 2013]

SYNDIG1 Products (3)

mRNA Protein Name
NM_001323606.2 NP_001310535.1 synapse differentiation-inducing gene protein 1
NM_001323607.2 NP_001310536.1 synapse differentiation-inducing gene protein 1
NM_024893.3 NP_079169.1 synapse differentiation-inducing gene protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of synapse assembly IDA
IDA: Inferred from direct assay
20152115 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYNDIG1 Protein Structure

CD225

CD225: Interferon-induced transmembrane protein (177 - 244)

  • 0
  • 100
  • 200
  • 258 a.a.
Protein Preferred Names Protein Names

synapse differentiation-inducing gene protein 1

  • dispanin subfamily C member 2

SYNDIG1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SYNDIG1 Q9H7V2 SLC16A13 Homo sapiens Q7RTY0
Y2H Array
32296183
Intra
SYNDIG1 Q9H7V2 SLC16A13 Homo sapiens Q7RTY0
Y2H Prey Pooling
32296183
Intra
SYNDIG1 Q9H7V2 TLCD4 Homo sapiens Q96MV1
Y2H Array
32296183
Intra
SYNDIG1 Q9H7V2 TLCD4 Homo sapiens Q96MV1
Y2H Prey Pooling
32296183
Intra
SYNDIG1 Q9H7V2 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
SYNDIG1 Q9H7V2 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
SYNDIG1 Q9H7V2 GPRC5D Homo sapiens Q9NZD1
Validated Y2H
32296183
Intra
SYNDIG1 Q9H7V2 SLC35C2 Homo sapiens Q9NQQ7-3
Validated Y2H
32296183
Intra
SYNDIG1 Q9H7V2 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra
SYNDIG1 Q9H7V2 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra
SYNDIG1 Q9H7V2 GPR42 Homo sapiens O15529
Y2H Array
32296183
Intra
SYNDIG1 Q9H7V2 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra
SYNDIG1 Q9H7V2 ELOVL4 Homo sapiens Q9GZR5
Y2H Prey Pooling
32296183
Intra
SYNDIG1 Q9H7V2 ELOVL4 Homo sapiens Q9GZR5
Y2H Array
32296183
Intra
SYNDIG1 Q9H7V2 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra
SYNDIG1 Q9H7V2 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra
SYNDIG1 Q9H7V2 FATE1 Homo sapiens Q969F0
Y2H Prey Pooling
32296183
Intra
SYNDIG1 Q9H7V2 FATE1 Homo sapiens Q969F0
Y2H Array
32296183
Intra
SYNDIG1 Q9H7V2 FATE1 Homo sapiens Q969F0
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Osteogenesis Imperfecta, Type V

  • Osteogenesis Imperfecta Type 5

  • OI5

  • Osteogenesis Imperfecta Type V

  • Oi Type 5

  • Oi Type V

  • Oi, Type V

  • Oi With Calcification In Interosseous Membranes

  • Type V Oi

  • Osteogenesis Imperfecta 5

  • Oi-V
Gliofibroma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14083 SYNDIG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14084 SYNDIG1L Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SYNDIG1 VGNC VGNC:35519
Macaca mulatta SYNDIG1 VGNC VGNC:78130
Rattus norvegicus SYNDIG1 RGD RGD:1310753
Felis catus SYNDIG1 VGNC VGNC:81233
Canis familiaris SYNDIG1 VGNC VGNC:47025
Mus musculus SYNDIG1 MGD MGI:3702158
Others SYNDIG1 NCBI