2. Gene
  3. TM4SF4 - transmembrane 4 L six family member 4 Gene

TM4SF4 - transmembrane 4 L six family member 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ILTMP; il-TMP

Gene ID: 7104 | Gene type: protein coding

About TM4SF4

Cytogenetic location: 3q25.1 Genomic coordinates (GRCh38): 3:149,474,697-149,503,394 (from NCBI)

This gene has 3 transcripts (splice variants), 211 orthologues and 5 paralogues. Biased expression in gall bladder (RPKM 554.1), duodenum (RPKM 308.9) and 2 other tissues.

Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation.[provided by RefSeq, Mar 2011]

TM4SF4 Products(1)

mRNA Protein Name
NM_004617.4 NP_004608.1 transmembrane 4 L6 family member 4

TM4SF4 Protein Structure

L6_membrane

L6_membrane: L6 membrane protein (1 - 192)

  • 0
  • 100
  • 202 a.a.
Protein Preferred Names Protein Names

transmembrane 4 L6 family member 4

intestinal and liver (il) tetraspan membrane protein

Related Diseases

Diseases Alias
Cutis Laxa, Autosomal Dominant 2

ADCL2

Autosomal Dominant Cutis Laxa 2

Cutis Laxa, Autosomal Dominant, 2

Cutis Laxa, Autosomal Dominant, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14609 TM4SF4 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TM4SF4 VGNC VGNC:102855
Macaca mulatta TM4SF4 VGNC VGNC:78564
Mus musculus TM4SF4 MGD MGI:2385173
Canis familiaris TM4SF4 VGNC VGNC:47409
Rattus norvegicus TM4SF4 RGD RGD:621784
Bos taurus TM4SF4 VGNC VGNC:35906