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TM4SF4 - transmembrane 4 L six family member 4 Gene

Also Known as ILTMP; il-TMP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7104

About TM4SF4

Cytogenetic location: 3q25.1 Genomic coordinates (GRCh38): 3:149,474,697-149,503,394 (from NCBI)

This gene has 3 transcripts (splice variants), 211 orthologues and 5 paralogues. Biased expression in gall bladder (RPKM 554.1), duodenum (RPKM 308.9) and 2 other tissues.

Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation.[provided by RefSeq, Mar 2011]

TM4SF4 Products (1)

mRNA	Protein	Name
NM_004617.4	NP_004608.1	transmembrane 4 L6 family member 4

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TM4SF4 Protein Structure

L6_membrane

0
100
202 a.a.

Protein Preferred Names	Protein Names
transmembrane 4 L6 family member 4	intestinal and liver (il) tetraspan membrane protein

TM4SF4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TM4SF4	P48230	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	TM4SF4	P48230	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	TM4SF4	P48230	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	TM4SF4	P48230	CLEC17A	Homo sapiens	Q6ZS10	Y2H Prey Pooling	32296183
Intra	TM4SF4	P48230	CLEC17A	Homo sapiens	Q6ZS10	Validated Y2H	32296183
Intra	TM4SF4	P48230	CLEC17A	Homo sapiens	Q6ZS10	Y2H Array	32296183
Intra	TM4SF4	P48230	OPRM1	Homo sapiens	P35372-10	Y2H Prey Pooling	32296183
Intra	TM4SF4	P48230	OPRM1	Homo sapiens	P35372-10	Y2H Array	32296183
Intra	TM4SF4	P48230	GJB4	Homo sapiens	Q9NTQ9	Y2H Prey Pooling	32296183
Intra	TM4SF4	P48230	GJB4	Homo sapiens	Q9NTQ9	Y2H Array	32296183
Intra	TM4SF4	P48230	GJB4	Homo sapiens	Q9NTQ9	Validated Y2H	32296183
Intra	TM4SF4	P48230	GJB1	Homo sapiens	P08034	Y2H Prey Pooling	32296183
Intra	TM4SF4	P48230	GJB1	Homo sapiens	P08034	Y2H Array	32296183
Intra	TM4SF4	P48230	GPR101	Homo sapiens	Q96P66	Y2H Prey Pooling	32296183
Intra	TM4SF4	P48230	GPR101	Homo sapiens	Q96P66	Validated Y2H	32296183
Intra	TM4SF4	P48230	GPR101	Homo sapiens	Q96P66	Y2H Array	32296183
Intra	TM4SF4	P48230	GPR42	Homo sapiens	O15529	Y2H Prey Pooling	32296183
Intra	TM4SF4	P48230	GPR42	Homo sapiens	O15529	Y2H Array	32296183
Intra	TM4SF4	P48230	SLC10A6	Homo sapiens	Q3KNW5	Validated Y2H	32296183
Intra	TM4SF4	P48230	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	TM4SF4	P48230	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	TM4SF4	P48230	TBXA2R	Homo sapiens	Q0VAB0	Validated Y2H	32296183
Intra	TM4SF4	P48230	TBXA2R	Homo sapiens	Q0VAB0	Y2H Array	32296183
Intra	TM4SF4	P48230	TBXA2R	Homo sapiens	Q0VAB0	Y2H Prey Pooling	32296183
Intra	TM4SF4	P48230	CMTM2	Homo sapiens	Q8TAZ6	Y2H Array	32296183
Intra	TM4SF4	P48230	CMTM2	Homo sapiens	Q8TAZ6	Y2H Prey Pooling	32296183
Intra	TM4SF4	P48230	CMTM2	Homo sapiens	Q8TAZ6	Validated Y2H	32296183
Intra	TM4SF4	P48230	APH1B	Homo sapiens	Q8WW43	Validated Y2H	32296183
Intra	TM4SF4	P48230	APH1B	Homo sapiens	Q8WW43	Y2H Prey Pooling	32296183
Intra	TM4SF4	P48230	APH1B	Homo sapiens	Q8WW43	Y2H Array	32296183
Intra	TM4SF4	P48230	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183
Intra	TM4SF4	P48230	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	32296183
Intra	TM4SF4	P48230	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
Intra	TM4SF4	P48230	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	TM4SF4	P48230	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	TM4SF4	P48230	GPR37L1	Homo sapiens	O60883	Y2H Array	32296183
Intra	TM4SF4	P48230	GPR37L1	Homo sapiens	O60883	Y2H Prey Pooling	32296183
Intra	TM4SF4	P48230	GJB5	Homo sapiens	O95377	Y2H Array	32296183
Intra	TM4SF4	P48230	GJB5	Homo sapiens	O95377	Y2H Prey Pooling	32296183
Intra	TM4SF4	P48230	KCNK5	Homo sapiens	O95279	Y2H Prey Pooling	32296183
Intra	TM4SF4	P48230	KCNK5	Homo sapiens	O95279	Y2H Array	32296183
Intra	TM4SF4	P48230	FATE1	Homo sapiens	Q969F0	Y2H Array	25416956
Intra	TM4SF4	P48230	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	25416956
Intra	TM4SF4	P48230	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	TM4SF4	P48230	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	TM4SF4	P48230	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	TM4SF4	P48230	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	TM4SF4	P48230	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	TM4SF4	P48230	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	TM4SF4	P48230	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	TM4SF4	P48230	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cutis Laxa, Autosomal Dominant 2	ADCL2 Autosomal Dominant Cutis Laxa 2 Cutis Laxa, Autosomal Dominant, 2 Cutis Laxa, Autosomal Dominant, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14609	TM4SF4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TM4SF4	VGNC	VGNC:102855
Macaca mulatta	TM4SF4	VGNC	VGNC:78564
Mus musculus	TM4SF4	MGD	MGI:2385173
Canis familiaris	TM4SF4	VGNC	VGNC:47409
Rattus norvegicus	TM4SF4	RGD	RGD:621784
Bos taurus	TM4SF4	VGNC	VGNC:35906
Others	TM4SF4	NCBI