KCNK5 - potassium two pore domain channel subfamily K member 5 Gene

Homo sapiens

Also known as TASK2; K2p5.1; KCNK5b; TASK-2

Gene ID: 8645 | Gene type: protein coding

About KCNK5

Cytogenetic location: 6p21.2 Genomic coordinates (GRCh38): 6:39,188,971-39,229,475 (from NCBI)

This gene has 1 transcript (splice variant), 285 orthologues and 14 paralogues. Broad expression in small intestine (RPKM 18.5), kidney (RPKM 17.9) and 19 other tissues.

Summary

This gene encodes one of the members of the superfamily of Potassium Channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport. [provided by RefSeq, Jul 2008]

KCNK5 Products(1)

mRNA	Protein	Name
NM_003740.4	NP_003731.1	potassium channel subfamily K member 5

KCNK5 Protein Structure

Ion_trans_2

0
100
200
300
400
499 a.a.

Protein Preferred Names

Protein Names

potassium channel subfamily K member 5

K2P5.1 potassium channel

Related Diseases

Diseases

Alias

Migraine Without Aura

Common Migraine	Migraine With Or Without Aura, Susceptibility To
Migraine Without Aura, Susceptibility To	Acute Migraine Without Aura

Birk-Barel Syndrome

Birk-Barel Mental Retardation Dysmorphism Syndrome	BIBARS
Mental Retardation With Hypotonia And Facial Dysmorphism	Intellectual Disability-Hypotonia-Facial Dysmorphism Syndrome
Kcnk9 Imprinting Syndrome

Danubian Endemic Familial Nephropathy

Balkan Nephropathy	Balkan Endemic Nephropathy
Nephropathia Epidemica	Defn
Ben	Aristolochic Acid Nephropathy
Aan	Endemic Nephropathy Balkan
Balkan Nephritis

Congenital Central Hypoventilation Syndrome

Cchs	Haddad Syndrome
Ondine Curse	Ondine Syndrome
Congenital Central Hypoventilation	Congenital Central Alveolar Hypoventilation Syndrome
Congenital Failure Of Autonomic Control	Ondine'S Curse
Primary Alveolar Hypoventilation	Ondine-Hirschsprung Disease
Central Congenital Hypoventilation Syndrome	Congenital Ondine Curse
Idiopathic Congenital Central Alveolar Hypoventilation	Congenital Central Alveolar Hypoventilation-Hirschsprung Disease Syndrome
Ondine-Hirschsprung Syndrome

Osteopetrosis, Autosomal Recessive 3

Osteopetrosis With Renal Tubular Acidosis	Marble Brain Disease
OPTB3	Guibaud-Vainsel Syndrome
Carbonic Anhydrase Ii Deficiency	Osteopetrosis, Autosomal Recessive 3, With Renal Tubular Acidosis
Autosomal Recessive Osteopetrosis 3	Carbonic Anhydrase 2 Deficiency
Autosomal Recessive Osteopetrosis 3 With Renal Tubular Acidosis	Osteopetrosis Autosomal Recessive 3
Autosomal Recessive Osteopetrosis Type 3	Guibaud Vainsel Syndrome
Mixed Rta	Mixed Renal Tubular Acidosis
Renal Tubular Acidosis Type 3	Carbonic Anhydrase Ii Deficiency Syndrome
Carbonic Anhydrase Ii Variant	Osteopetrosis, Autosomal Recessive, Type 3
Carbonic Anhydrase 2

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07161	KCNK5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	KCNK5	VGNC	VGNC:42277
Mus musculus	KCNK5	MGD	MGI:1336175
Macaca mulatta	KCNK5	VGNC	VGNC:73995
Felis catus	KCNK5	VGNC	VGNC:67922
Rattus norvegicus	KCNK5	RGD	RGD:1564985
Bos taurus	KCNK5	VGNC	VGNC:30475

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