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KCNK5 - potassium two pore domain channel subfamily K member 5 Gene

Also Known as TASK2; K2p5.1; KCNK5b; TASK-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8645

About KCNK5

Cytogenetic location: 6p21.2 Genomic coordinates (GRCh38): 6:39,188,971-39,229,475 (from NCBI)

This gene has 1 transcript (splice variant), 285 orthologues and 14 paralogues. Broad expression in small intestine (RPKM 18.5), kidney (RPKM 17.9) and 19 other tissues.

Summary

This gene encodes one of the members of the superfamily of Potassium Channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport. [provided by RefSeq, Jul 2008]

KCNK5 Products (1)

mRNA	Protein	Name
NM_003740.4	NP_003731.1	potassium channel subfamily K member 5

KCNK5 Protein Structure

Ion_trans_2

0
100
200
300
400
499 a.a.

Protein Preferred Names	Protein Names
potassium channel subfamily K member 5	K2P5.1 potassium channel

KCNK5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KCNK5	O95279	TMEM128	Homo sapiens	Q5BJH2-2	Validated Y2H	32296183
Intra	KCNK5	O95279	ADIPOQ	Homo sapiens	Q15848	Validated Y2H	32296183
Intra	KCNK5	O95279	AGTRAP	Homo sapiens	Q6RW13-2	Validated Y2H	32296183
Intra	KCNK5	O95279	CMTM5	Homo sapiens	Q96DZ9-2	Validated Y2H	32296183
Intra	KCNK5	O95279	TSPAN33	Homo sapiens	Q86UF1	Validated Y2H	32296183
Intra	KCNK5	O95279	STRIT1	Homo sapiens	P0DN84	Validated Y2H	32296183
Intra	KCNK5	O95279	MAN2B2	Homo sapiens	Q9Y2E5	Validated Y2H	32296183
Intra	KCNK5	O95279	ATP5PF	Homo sapiens	P18859	Validated Y2H	32296183
Intra	KCNK5	O95279	TMEM14A	Homo sapiens	Q9Y6G1	Validated Y2H	32296183
Intra	KCNK5	O95279	TMEM176A	Homo sapiens	Q96HP8	Validated Y2H	32296183
Intra	KCNK5	O95279	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	32296183
Intra	KCNK5	O95279	TMEM60	Homo sapiens	Q9H2L4	Validated Y2H	32296183
Intra	KCNK5	O95279	COMT	Homo sapiens	P21964	Validated Y2H	32296183
Intra	KCNK5	O95279	GJB2	Homo sapiens	P29033	Validated Y2H	32296183
Intra	KCNK5	O95279	SLC66A2	Homo sapiens	Q8N2U9	Validated Y2H	32296183
Intra	KCNK5	O95279	TMEM54	Homo sapiens	Q969K7	Validated Y2H	32296183
Intra	KCNK5	O95279	IGFBP5	Homo sapiens	P24593	Validated Y2H	32296183
Intra	KCNK5	O95279	ORMDL3	Homo sapiens	Q8N138	Validated Y2H	32296183
Intra	KCNK5	O95279	VAMP3	Homo sapiens	Q15836	Validated Y2H	32296183
Intra	KCNK5	O95279	AQP1	Homo sapiens	P29972	Validated Y2H	32296183
Intra	KCNK5	O95279	YIPF6	Homo sapiens	Q96EC8	Validated Y2H	32296183
Intra	KCNK5	O95279	BNIP2	Homo sapiens	Q12982	Validated Y2H	32296183
Intra	KCNK5	O95279	SMCO4	Homo sapiens	Q9NRQ5	Validated Y2H	32296183
Intra	KCNK5	O95279	TM4SF4	Homo sapiens	P48230	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

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Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07161	KCNK5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	KCNK5	VGNC	VGNC:42277
Mus musculus	KCNK5	MGD	MGI:1336175
Macaca mulatta	KCNK5	VGNC	VGNC:73995
Felis catus	KCNK5	VGNC	VGNC:67922
Rattus norvegicus	KCNK5	RGD	RGD:1564985
Bos taurus	KCNK5	VGNC	VGNC:30475
Others	KCNK5	NCBI