ATP5PF - ATP synthase peripheral stalk subunit F6 Gene

Also Known as F6; CF6; ATP5; ATPM; ATP5A; ATP5J

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 522

About ATP5PF

Cytogenetic location: 21q21.3 Genomic coordinates (GRCh38): 21:25,724,500-25,735,653 (from NCBI)

This gene has 8 transcripts (splice variants) and 293 orthologues. Ubiquitous expression in heart (RPKM 71.0), kidney (RPKM 49.2) and 25 other tissues.

Summary

Mitochondrial ATP Synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during Oxidative Phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the Other 3. The Fo complex has nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the F6 subunit of the Fo complex. The F6 subunit is required for F1 and Fo interactions. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. This gene has 1 or more pseudogenes. [provided by RefSeq, Feb 2016]

ATP5PF Products (7)

mRNA Protein Name
NM_001003696.2 NP_001003696.1 ATP synthase-coupling factor 6, mitochondrial isoform a precursor
NM_001003697.2 NP_001003697.1 ATP synthase-coupling factor 6, mitochondrial isoform a precursor
NM_001003701.2 NP_001003701.1 ATP synthase-coupling factor 6, mitochondrial isoform b precursor
NM_001003703.2 NP_001003703.1 ATP synthase-coupling factor 6, mitochondrial isoform a precursor
NM_001320266.2 NP_001307195.1 ATP synthase-coupling factor 6, mitochondrial isoform a precursor
NM_001320267.2 NP_001307196.1 ATP synthase-coupling factor 6, mitochondrial isoform a precursor
NM_001685.5 NP_001676.2 ATP synthase-coupling factor 6, mitochondrial isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
27499296 GOA
contributes to proton-transporting ATP synthase activity, rotational mechanism IDA
IDA: Inferred from direct assay
12110673 GOA
Biological Process GO Annotation Evidence References Source
involved in proton motive force-driven mitochondrial ATP synthesis IDA
IDA: Inferred from direct assay
12110673 GOA
Cellular Component GO Annotation Evidence References Source
part of proton-transporting ATP synthase complex IDA
IDA: Inferred from direct assay
12110673 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATP5PF Protein Structure

ATP-synt_F6

ATP-synt_F6: Mitochondrial ATP synthase coupling factor 6 (1 - 97)

  • 0
  • 100
  • 108 a.a.
Protein Preferred Names Protein Names

ATP synthase-coupling factor 6, mitochondrial

  • ATP synthase subunit h

ATP5PF Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ATP5PF P18859 NDRG4 Homo sapiens Q9ULP0-2
Validated Y2H
32296183
Intra
ATP5PF P18859 MIEF2 Homo sapiens Q96C03-3
Validated Y2H
32296183
Intra
ATP5PF P18859 REEP6 Homo sapiens Q96HR9-2
Validated Y2H
32296183
Intra
ATP5PF P18859 REEP6 Homo sapiens Q96HR9-2
Y2H Array
32296183
Intra
ATP5PF P18859 REEP6 Homo sapiens Q96HR9-2
Y2H Prey Pooling
32296183
Intra
ATP5PF P18859 SIGLEC12 Homo sapiens Q96PQ1
Y2H Array
32296183
Intra
ATP5PF P18859 SIGLEC12 Homo sapiens Q96PQ1
Y2H Prey Pooling
32296183
Intra
ATP5PF P18859 SIGLEC12 Homo sapiens Q96PQ1
Validated Y2H
32296183
Intra
ATP5PF P18859 PHOSPHO2 Homo sapiens Q8TCD6
Validated Y2H
32296183
Intra
ATP5PF P18859 ATP5F1A Homo sapiens P25705
Crosslink
30021884
Intra
ATP5PF P18859 ATP5F1A Homo sapiens P25705
Anti Tag CoIP
33961781
Intra
ATP5PF P18859 KCNK5 Homo sapiens O95279
Y2H Prey Pooling
32296183
Intra
ATP5PF P18859 KCNK5 Homo sapiens O95279
Y2H Array
32296183
Intra
ATP5PF P18859 PLP2 Homo sapiens Q04941
Validated Y2H
32296183
Intra
ATP5PF P18859 BCL2L2 Homo sapiens Q92843
Validated Y2H
32296183
Intra
ATP5PF P18859 ATP5PD Homo sapiens O75947
Anti Tag CoIP
33961781
Intra
ATP5PF P18859 MIEF1 Homo sapiens Q9NQG6
Validated Y2H
32296183
Intra
ATP5PF P18859 PTPN9 Homo sapiens P43378
Validated Y2H
32296183
Intra
ATP5PF P18859 INPP5K Homo sapiens Q9BT40
Validated Y2H
32296183
Intra
ATP5PF P18859 MALL Homo sapiens Q13021
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

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Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01212 ATP5PF Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ATP5PF VGNC VGNC:26304
Rattus norvegicus ATP5PF RGD RGD:621376
Felis catus ATP5PF VGNC VGNC:68647
Mus musculus ATP5PF MGD MGI:107777
Canis familiaris ATP5PF VGNC VGNC:38265
Macaca mulatta ATP5PF VGNC VGNC:81288
Others ATP5PF NCBI