PLP2 - proteolipid protein 2 Gene

Also Known as A4; A4LSB

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5355

About PLP2

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:49,171,898-49,175,235 (from NCBI)

This gene has 2 transcripts (splice variants), 233 orthologues and 14 paralogues. Ubiquitous expression in skin (RPKM 154.7), esophagus (RPKM 126.0) and 23 other tissues.

Summary

This gene encodes an integral membrane protein that localizes to the endoplasmic reticulum in colonic epithelial cells. The encoded protein can multimerize and may function as an ion channel. A polymorphism in the promoter of this gene may be linked to an increased risk of X-linked cognitive disability. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Jan 2010]

PLP2 Products (1)

mRNA	Protein	Name
NM_002668.3	NP_002659.1	proteolipid protein 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chemokine binding	IPI IPI: Inferred from physical interaction	15474493	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15474493	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	15474493	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLP2 Protein Structure

MARVEL

0
100
152 a.a.

Protein Preferred Names	Protein Names
proteolipid protein 2	A4 differentiation-dependent protein

PLP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PLP2	Q04941	SPN	Homo sapiens	P16150	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	SPN	Homo sapiens	P16150	Y2H Array	32296183
Intra	PLP2	Q04941	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	RETREG3	Homo sapiens	Q86VR2	Validated Y2H	32296183
Intra	PLP2	Q04941	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	PLP2	Q04941	SGPL1	Homo sapiens	O95470	Y2H Array	32296183
Intra	PLP2	Q04941	SGPL1	Homo sapiens	O95470	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Array	32296183
Intra	PLP2	Q04941	HSD17B11	Homo sapiens	Q8NBQ5	Validated Y2H	32296183
Intra	PLP2	Q04941	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	ELOVL5	Homo sapiens	Q9NYP7	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	ELOVL5	Homo sapiens	Q9NYP7	Validated Y2H	32296183
Intra	PLP2	Q04941	ELOVL5	Homo sapiens	Q9NYP7	Y2H Array	32296183
Intra	PLP2	Q04941	PTGES	Homo sapiens	O14684	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	PTGES	Homo sapiens	O14684	Y2H Array	32296183
Intra	PLP2	Q04941	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	PLP2	Q04941	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	PLP2	Q04941	GPR151	Homo sapiens	Q8TDV0	Y2H Array	32296183
Intra	PLP2	Q04941	GPR151	Homo sapiens	Q8TDV0	Validated Y2H	32296183
Intra	PLP2	Q04941	GPR151	Homo sapiens	Q8TDV0	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	NDRG4	Homo sapiens	Q9ULP0-2	Validated Y2H	32296183
Intra	PLP2	Q04941	FNDC9	Homo sapiens	Q8TBE3	Validated Y2H	32296183
Intra	PLP2	Q04941	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
Intra	PLP2	Q04941	TMPRSS2	Homo sapiens	O15393-2	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	TMPRSS2	Homo sapiens	O15393-2	Y2H Array	32296183
Intra	PLP2	Q04941	ASGR2	Homo sapiens	P07307-3	Y2H Array	32296183
Intra	PLP2	Q04941	ASGR2	Homo sapiens	P07307-3	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	SLC14A2	Homo sapiens	Q15849	Y2H Array	32296183
Intra	PLP2	Q04941	SLC14A2	Homo sapiens	Q15849	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	SLC14A2	Homo sapiens	Q15849	Validated Y2H	32296183
Intra	PLP2	Q04941	CRB3	Homo sapiens	Q9BUF7-2	Y2H Array	32296183
Intra	PLP2	Q04941	CRB3	Homo sapiens	Q9BUF7-2	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	CRB3	Homo sapiens	Q9BUF7-2	Validated Y2H	32296183
Intra	PLP2	Q04941	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	SCN3B	Homo sapiens	Q9NY72	Validated Y2H	32296183
Intra	PLP2	Q04941	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	PLP2	Q04941	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	SLC35C2	Homo sapiens	Q9NQQ7-3	Validated Y2H	32296183
Intra	PLP2	Q04941	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Array	32296183
Intra	PLP2	Q04941	SLC18A1	Homo sapiens	P54219-3	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	SLC18A1	Homo sapiens	P54219-3	Y2H Array	32296183
Intra	PLP2	Q04941	PIGP	Homo sapiens	P57054	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	PIGP	Homo sapiens	P57054	Y2H Array	32296183
Intra	PLP2	Q04941	CPLX4	Homo sapiens	Q7Z7G2	Validated Y2H	32296183
Intra	PLP2	Q04941	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
Intra	PLP2	Q04941	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	HSD17B13	Homo sapiens	Q7Z5P4	Validated Y2H	32296183
Intra	PLP2	Q04941	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	PLP2	Q04941	SLC2A13	Homo sapiens	Q96QE2	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	SLC2A13	Homo sapiens	Q96QE2	Validated Y2H	32296183
Intra	PLP2	Q04941	SLC2A13	Homo sapiens	Q96QE2	Y2H Array	32296183
Intra	PLP2	Q04941	LHFPL1	Homo sapiens	Q86WI0	Validated Y2H	32296183
Intra	PLP2	Q04941	LHFPL1	Homo sapiens	Q86WI0	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	LHFPL1	Homo sapiens	Q86WI0	Y2H Array	32296183
Intra	PLP2	Q04941	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	PLP2	Q04941	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	PLP2	Q04941	CLDN5	Homo sapiens	O00501	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	CLDN5	Homo sapiens	O00501	Y2H Array	32296183
Intra	PLP2	Q04941	FAM210B	Homo sapiens	Q96KR6	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	FAM210B	Homo sapiens	Q96KR6	Validated Y2H	32296183
Intra	PLP2	Q04941	FAM210B	Homo sapiens	Q96KR6	Y2H Array	32296183
Intra	PLP2	Q04941	AQP8	Homo sapiens	O94778	Y2H Array	32296183
Intra	PLP2	Q04941	AQP8	Homo sapiens	O94778	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	ATP5PF	Homo sapiens	P18859	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	ATP5PF	Homo sapiens	P18859	Y2H Array	32296183
Intra	PLP2	Q04941	CERS4	Homo sapiens	Q9HA82	Validated Y2H	32296183
Intra	PLP2	Q04941	CERS4	Homo sapiens	Q9HA82	Y2H Array	32296183
Intra	PLP2	Q04941	CERS4	Homo sapiens	Q9HA82	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	CYBC1	Homo sapiens	Q9BQA9	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	CYBC1	Homo sapiens	Q9BQA9	Validated Y2H	32296183
Intra	PLP2	Q04941	CYBC1	Homo sapiens	Q9BQA9	Y2H Array	32296183
Intra	PLP2	Q04941	AQP3	Homo sapiens	Q92482	Validated Y2H	32296183
Intra	PLP2	Q04941	AQP3	Homo sapiens	Q92482	Y2H Array	32296183
Intra	PLP2	Q04941	AQP3	Homo sapiens	Q92482	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	32296183
Intra	PLP2	Q04941	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
Intra	PLP2	Q04941	EVI2A	Homo sapiens	P22794	Y2H Array	32296183
Intra	PLP2	Q04941	EVI2A	Homo sapiens	P22794	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	DNAJC1	Homo sapiens	Q96KC8	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	DNAJC1	Homo sapiens	Q96KC8	Validated Y2H	32296183
Intra	PLP2	Q04941	DNAJC1	Homo sapiens	Q96KC8	Y2H Array	32296183
Intra	PLP2	Q04941	RNF5	Homo sapiens	Q99942	Validated Y2H	32296183
Intra	PLP2	Q04941	RNF5	Homo sapiens	Q99942	Y2H Array	32296183
Intra	PLP2	Q04941	RNF5	Homo sapiens	Q99942	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	PLP2	Q04941	EBP	Homo sapiens	Q15125	Validated Y2H	32296183
Intra	PLP2	Q04941	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	DARS2	Homo sapiens	Q6PI48	Validated Y2H	32296183
Intra	PLP2	Q04941	DARS2	Homo sapiens	Q6PI48	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	DARS2	Homo sapiens	Q6PI48	Y2H Array	32296183
Intra	PLP2	Q04941	PVR	Homo sapiens	P15151	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	PVR	Homo sapiens	P15151	Y2H Array	32296183
Intra	PLP2	Q04941	SAR1A	Homo sapiens	Q9NR31	Validated Y2H	32296183
Intra	PLP2	Q04941	SAR1A	Homo sapiens	Q9NR31	Y2H Array	32296183
Intra	PLP2	Q04941	SAR1A	Homo sapiens	Q9NR31	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	LRRC4C	Homo sapiens	Q9HCJ2	Validated Y2H	32296183
Intra	PLP2	Q04941	LRRC4C	Homo sapiens	Q9HCJ2	Y2H Array	32296183
Intra	PLP2	Q04941	LRRC4C	Homo sapiens	Q9HCJ2	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	PACC1	Homo sapiens	Q9H813	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	PACC1	Homo sapiens	Q9H813	Validated Y2H	32296183
Intra	PLP2	Q04941	PACC1	Homo sapiens	Q9H813	Y2H Array	32296183
Intra	PLP2	Q04941	CCR1	Homo sapiens	P32246	Anti Tag CoIP	15474493
Intra	PLP2	Q04941	CCR1	Homo sapiens	P32246	Y2H	15474493
Intra	PLP2	Q04941	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	PLP2	Q04941	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	PLP2	Q04941	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	TM4SF19	Homo sapiens	Q96DZ7	Validated Y2H	32296183
Intra	PLP2	Q04941	TM4SF19	Homo sapiens	Q96DZ7	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	TM4SF19	Homo sapiens	Q96DZ7	Y2H Array	32296183
Intra	PLP2	Q04941	CD53	Homo sapiens	P19397	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	CD53	Homo sapiens	P19397	Y2H Array	32296183
Intra	PLP2	Q04941	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	PLP2	Q04941	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	PLP2	Q04941	BIK	Homo sapiens	Q13323	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	BIK	Homo sapiens	Q13323	Validated Y2H	32296183
Intra	PLP2	Q04941	BIK	Homo sapiens	Q13323	Y2H Array	32296183
Intra	PLP2	Q04941	PDZK1IP1	Homo sapiens	Q13113	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	PDZK1IP1	Homo sapiens	Q13113	Validated Y2H	32296183
Intra	PLP2	Q04941	PDZK1IP1	Homo sapiens	Q13113	Y2H Array	32296183
Intra	PLP2	Q04941	MGST3	Homo sapiens	O14880	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	MGST3	Homo sapiens	O14880	Y2H Array	32296183
Intra	PLP2	Q04941	TMEM51	Homo sapiens	Q9NW97	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	TMEM51	Homo sapiens	Q9NW97	Validated Y2H	32296183
Intra	PLP2	Q04941	TMEM51	Homo sapiens	Q9NW97	Y2H Array	32296183
Intra	PLP2	Q04941	THAP4	Homo sapiens	Q8WY91	Validated Y2H	32296183
Intra	PLP2	Q04941	THAP4	Homo sapiens	Q8WY91	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	THAP4	Homo sapiens	Q8WY91	Y2H Array	32296183
Intra	PLP2	Q04941	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183
Intra	PLP2	Q04941	FATE1	Homo sapiens	Q969F0	Validated Y2H	32296183
Intra	PLP2	Q04941	FATE1	Homo sapiens	Q969F0	Y2H Array	32296183
Intra	PLP2	Q04941	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	25416956
Intra	PLP2	Q04941	BNIP3	Homo sapiens	Q12983	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	BNIP3	Homo sapiens	Q12983	Validated Y2H	32296183
Intra	PLP2	Q04941	BNIP3	Homo sapiens	Q12983	Y2H Array	32296183
Intra	PLP2	Q04941	CIAO2A	Homo sapiens	Q9H5X1	Validated Y2H	32296183
Intra	PLP2	Q04941	CIAO2A	Homo sapiens	Q9H5X1	Y2H Array	32296183
Intra	PLP2	Q04941	CIAO2A	Homo sapiens	Q9H5X1	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
Intra	PLP2	Q04941	REEP4	Homo sapiens	Q9H6H4	Validated Y2H	32296183
Intra	PLP2	Q04941	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	PLP2	Q04941	CYBRD1	Homo sapiens	Q53TN4	Y2H Array	32296183
Intra	PLP2	Q04941	CYBRD1	Homo sapiens	Q53TN4	Validated Y2H	32296183
Intra	PLP2	Q04941	CYBRD1	Homo sapiens	Q53TN4	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	PLP2	Q04941	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	PLP2	Q04941	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	CYB561	Homo sapiens	P49447	Y2H Array	32296183
Intra	PLP2	Q04941	CYB561	Homo sapiens	P49447	Y2H Prey Pooling	32296183
Intra	PLP2	Q04941	TMEM79	Homo sapiens	Q9BSE2	Y2H Array	31515488

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Croup	Acute Obstructive Laryngitis Laryngotracheobronchitis Acute Laryngotracheobronchitis Croup Syndrome Acute Laryngitis With Obstruction Obstructive Laryngitis Obstructive Laryngitis Nos Obstructive Laryngotracheitis Nos
Breast Adenocarcinoma	Mammary Adenocarcinoma Adenocarcinoma Of Breast

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P2296	Abz-FRLKGGAPIKGV-EDDNP TFA		/	Unkown
HY-RS10732	PLP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18492	Plp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24974	Plp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PLP2	VGNC	VGNC:56949
Mus musculus	PLP2	MGD	MGI:1298382
Felis catus	PLP2	VGNC	VGNC:101462
Rattus norvegicus	PLP2	RGD	RGD:1587363
Macaca mulatta	PLP2	VGNC	VGNC:76179
Others	PLP2	NCBI