DNAJC1 - DnaJ heat shock protein family (Hsp40) member C1 Gene

Also Known as HTJ1; MTJ1; ERdj1; DNAJL1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64215

About DNAJC1

Cytogenetic location: 10p12.31 Genomic coordinates (GRCh38): 10:21,756,548-22,003,730 (from NCBI)

This gene has 5 transcripts (splice variants), 208 orthologues and 20 paralogues. Ubiquitous expression in thyroid (RPKM 13.9), prostate (RPKM 10.4) and 25 other tissues.

Summary

The membrane protein encoded by this gene is a DNAJ-like heat shock protein that binds the molecular chaperone BiP. In addition, the encoded protein contains two SANT domains that have been shown to bind Serpin alpha1-antichymotrypsin and inter-alpha trypsin inhibitor heavy chain 4. [provided by RefSeq, Jul 2016]

DNAJC1 Products (1)

mRNA Protein Name
NM_022365.4 NP_071760.2 dnaJ homolog subfamily C member 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14668352 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of protein secretion IDA
IDA: Inferred from direct assay
14668352 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNAJC1 Protein Structure

DnaJ

DnaJ: DnaJ domain (65 - 126)

Myb_DNA-binding

Myb_DNA-binding: Myb-like DNA-binding domain (495 - 540)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 554 a.a.
Protein Preferred Names Protein Names

dnaJ homolog subfamily C member 1

  • DnaJ (Hsp40) homolog, subfamily C, member 1

DNAJC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DNAJC1 Q96KC8 CYP4F2 Homo sapiens P78329
Y2H Prey Pooling
32296183
Intra
DNAJC1 Q96KC8 LAMP2 Homo sapiens P13473-2
Validated Y2H
32814053
Intra
DNAJC1 Q96KC8 LAMP2 Homo sapiens P13473-2
Y2H Array
32814053
Intra
DNAJC1 Q96KC8 LAMP2 Homo sapiens P13473-2
Y2H Pooling
32814053
Intra
DNAJC1 Q96KC8 SH3GLB1 Homo sapiens Q9Y371
Y2H Pooling
32814053
Intra
DNAJC1 Q96KC8 SH3GLB1 Homo sapiens Q9Y371
Validated Y2H
32814053
Intra
DNAJC1 Q96KC8 SH3GLB1 Homo sapiens Q9Y371
Y2H Array
32814053
Intra
DNAJC1 Q96KC8 RMND1 Homo sapiens Q9NWS8
Anti Tag CoIP
33961781
Intra
DNAJC1 Q96KC8 RMND1 Homo sapiens Q9NWS8
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Pyometritis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03872 DNAJC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus DNAJC1 RGD RGD:2322144
Macaca mulatta DNAJC1 VGNC VGNC:106033
Mus musculus DNAJC1 MGD MGI:103268
Felis catus DNAJC1 VGNC VGNC:83868
Canis familiaris DNAJC1 VGNC VGNC:52128
Others DNAJC1 NCBI