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AQP3 - aquaporin 3 (Gill blood group) Gene

Also Known as GIL; AQP-3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 360

About AQP3

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:33,441,160-33,447,593 (from NCBI)

This gene has 7 transcripts (splice variants), 265 orthologues, 11 paralogues and is associated with 1 phenotype. Biased expression in esophagus (RPKM 430.5), skin (RPKM 178.1) and 9 other tissues.

Summary

This gene encodes the water channel protein Aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as Aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, Aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

AQP3 Products (2)

mRNA	Protein	Name
NM_001318144.2	NP_001305073.1	aquaporin-3 isoform 2
NM_004925.5	NP_004916.1	aquaporin-3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables glycerol channel activity	IDA IDA: Inferred from direct assay	17943189	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables water channel activity	EXP EXP: Inferred from Experiment	9369468	GOA
enables water channel activity	IDA IDA: Inferred from direct assay	30420639	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cellular response to hypoxia	IDA IDA: Inferred from direct assay	24462679	GOA
involved in glycerol transmembrane transport	IDA IDA: Inferred from direct assay	30420639	GOA
involved in odontogenesis	IEP IEP: Inferred from expression pattern	12522663	GOA
involved in positive regulation of immune system process	IDA IDA: Inferred from direct assay	17943189	GOA
involved in response to retinoic acid	IDA IDA: Inferred from direct assay	17943189	GOA
involved in water transport	IDA IDA: Inferred from direct assay	30420639	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell-cell junction	IDA IDA: Inferred from direct assay	18718702	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	18718702	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	14521551	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AQP3 Protein Structure

MIP

0
100
200
292 a.a.

Protein Preferred Names	Protein Names
aquaporin-3	aquaglyceroporin-3

AQP3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AQP3	Q92482	VASN	Homo sapiens	Q6EMK4	Y2H Prey Pooling	32296183
Intra	AQP3	Q92482	VASN	Homo sapiens	Q6EMK4	Y2H Array	32296183
Intra	AQP3	Q92482	SGPL1	Homo sapiens	O95470	Y2H Array	32296183
Intra	AQP3	Q92482	SGPL1	Homo sapiens	O95470	Y2H Prey Pooling	32296183
Intra	AQP3	Q92482	HIBADH	Homo sapiens	P31937	Y2H Prey Pooling	32296183
Intra	AQP3	Q92482	HIBADH	Homo sapiens	P31937	Y2H Array	32296183
Intra	AQP3	Q92482	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	AQP3	Q92482	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	AQP3	Q92482	MFF	Homo sapiens	Q9GZY8-5	Y2H Array	32296183
Intra	AQP3	Q92482	MFF	Homo sapiens	Q9GZY8-5	Y2H Prey Pooling	32296183
Intra	AQP3	Q92482	MFF	Homo sapiens	Q9GZY8-5	Validated Y2H	32296183
Intra	AQP3	Q92482	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	AQP3	Q92482	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	AQP3	Q92482	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	AQP3	Q92482	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	AQP3	Q92482	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	AQP3	Q92482	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	AQP3	Q92482	LEUTX	Homo sapiens	A8MZ59	Y2H Array	32296183
Intra	AQP3	Q92482	LEUTX	Homo sapiens	A8MZ59	Y2H Prey Pooling	32296183
Intra	AQP3	Q92482	EVI2B	Homo sapiens	P34910-2	Y2H Array	32296183
Intra	AQP3	Q92482	EVI2B	Homo sapiens	P34910-2	Y2H Prey Pooling	32296183
Intra	AQP3	Q92482	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	AQP3	Q92482	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	AQP3	Q92482	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	AQP3	Q92482	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	AQP3	Q92482	GIMAP5	Homo sapiens	Q96F15	Validated Y2H	32296183
Intra	AQP3	Q92482	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	AQP3	Q92482	ERG28	Homo sapiens	Q9UKR5	Validated Y2H	32296183
Intra	AQP3	Q92482	AQP3	Homo sapiens	Q92482	Y2H Prey Pooling	32296183
Intra	AQP3	Q92482	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	AQP3	Q92482	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	AQP3	Q92482	AQP3	Homo sapiens	Q92482	Validated Y2H	32296183
Intra	AQP3	Q92482	AQP3	Homo sapiens	Q92482	Y2H Array	32296183
Intra	AQP3	Q92482	SAR1A	Homo sapiens	Q9NR31	Validated Y2H	32296183
Intra	AQP3	Q92482	SAR1A	Homo sapiens	Q9NR31	Y2H Prey Pooling	32296183
Intra	AQP3	Q92482	SAR1A	Homo sapiens	Q9NR31	Y2H Array	32296183
Intra	AQP3	Q92482	MRM1	Homo sapiens	Q6IN84	Y2H Prey Pooling	32296183
Intra	AQP3	Q92482	MRM1	Homo sapiens	Q6IN84	Y2H Array	32296183
Intra	AQP3	Q92482	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	AQP3	Q92482	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

AQP3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81400	Aquaporin 3 Antibody (YA1145)	IHC-P	Human
HY-P81400A	Aquaporin 3 Antibody (YA1145)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Acrokeratoderma, Hereditary Papulotranslucent	Hereditary Papulotranslucent Acrokeratoderma
Oligohydramnios	Oligohydramnios - Delivered Antepartum Oligohydramnios Delivered Oligohydramnios Oligohydramnios, Antepartum Condition Or Complication Deficient Liquor Oligohydramnios, Unspecified Trimester Reduced Liquor Volume
Nephrogenic Diabetes Insipidus	Vasopressin-Resistant Diabetes Insipidus Diabetes Insipidus, Nephrogenic Diabetes Insipidus Nephrogenic Congenital Nephrogenic Diabetes Insipidus Adh Resistant Diabetes Insipidus Diabetes Insipidus Nephrogenic X-Linked Diabetes Insipidus Nephrogenic Type 1 Adh-Resistant Diabetes Insipidus Diabetes Insipidus Renalis Ndi Renal Diabetes Insipidus Familial Nephrogenic Diabetes Antidiuretic-Hormone-Resistant Diabetes Insipidus Adiuretin-Resistant Diabetes Insipidus Ndi - [Nephrogenic Diabetes Insipidus] Diabetes Tenuifluus Adh - [Antidiuretic-Hormone] Resistant Diabetes Insipidus Hereditary Nephrogenic Diabetes Insipidus Familial Nephrogenic Diabetes Insipidus Primary Nephrogenic Diabetes Insipidus
Diabetes Insipidus
Polyhydramnios
Constipation
Hydrarthrosis
Pompholyx	Dyshidrosis Vesicular Eczema Of Hands And/Or Feet Cheiropompholyx Dyshydrotic Eczema Eczema, Dyshidrotic Vesicular Hand Eczema
X-Linked Nephrogenic Diabetes Insipidus	Nephrogenic Diabetes Insipidus Type 1 Doid:0081060
Nephrotic Syndrome	Finnish Congenital Nephrotic Syndrome Ns - [Nephrotic Syndrome] Nephrosis Syndrome Nephrosis Nos Glomerular Lesion Nephrosis
Gestational Diabetes Insipidus	Transient Diabetes Insipidus Of Pregnancy Diabetes Insipidus Gestational Gestagenic Diabetes Insipidus Doid:0081057
Adrenal Gland Pheochromocytoma	Pheochromocytoma
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0557	Bisacodyl	Inhibitor	99.71%	Yes

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-126073	DFP00173		99.46%	Unkown
HY-126074	Z433927330		98.20%	Unkown
HY-RS00875	AQP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-157979	AQP3-IN-1	Inhibitor	/	Unkown
HY-RS17446	Aqp3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23902	Aqp3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	AQP3	VGNC	VGNC:51701
Mus musculus	AQP3	MGD	MGI:1333777
Macaca mulatta	AQP3	VGNC	VGNC:103241
Rattus norvegicus	AQP3	RGD	RGD:68428
Felis catus	AQP3	VGNC	VGNC:102901
Bos taurus	AQP3	VGNC	VGNC:56935
Others	AQP3	NCBI