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DFP00173 

Cat. No.: HY-126073 Purity: 99.33%
Handling Instructions

DFP00173 is a potent and selective aquaporin-3 (AQP3) inhibitor. DFP00173 inhibits mouse and human AQP3 with an IC50 of ∼0.1-0.4 μM. DFP00173 is selective for AQP3 over the homologous AQP isoforms AQP7 and AQP9.

For research use only. We do not sell to patients.

DFP00173 Chemical Structure

DFP00173 Chemical Structure

CAS No. : 672286-03-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
25 mg USD 990 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

DFP00173 is a potent and selective aquaporin-3 (AQP3) inhibitor. DFP00173 inhibits mouse and human AQP3 with an IC50 of ∼0.1-0.4 μM. DFP00173 is selective for AQP3 over the homologous AQP isoforms AQP7 and AQP9[1].

In Vitro

DFP00173 inhibits the glycerol permeability of human erythrocytes with an IC50 of ~0.2 µM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

332.16

Formula

C₁₁H₇Cl₂N₃O₃S

CAS No.

672286-03-2

SMILES

O=C(NC1=CSC([N+]([O-])=O)=C1)NC2=C(Cl)C=CC=C2Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (376.32 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0106 mL 15.0530 mL 30.1060 mL
5 mM 0.6021 mL 3.0106 mL 6.0212 mL
10 mM 0.3011 mL 1.5053 mL 3.0106 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.26 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.26 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.26 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.33%

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Keywords:

DFP00173DFP 00173DFP-00173OthershomologousAQPisoformsglycerolpermeabilityselectivehumanerythrocytesInhibitorinhibitorinhibit

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DFP00173
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HY-126073
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