Aquaporin 3 Antibody (YA1145)(PBS only)

Cat. No.: HY-P81400A: Data Sheet User Guide for Antibodies
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Aquaporin 3 Antibody (YA1145) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aquaporin 3.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

Aquaporin 3 Antibody (YA1145) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aquaporin 3.

Host

Rabbit

Molecular Weight

Predicted band size: 32 kDa;

Observed band size: 32 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q92482

Gene ID

360 [NCBI]

Immunogen

A synthesized peptide derived from human AQP3

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:100-1:200

Purity	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed:12239222, PubMed:30420639). Could also be permeable to urea (By similarity). Also participates in cell permeability to H2O2 and H2O2-mediated signaling (PubMed:20724658). In skin, transports glycerol to the epidermis and stratum corneum, where it maintains hydration, elasticity, and supports lipid biosynthesis for barrier repair (By similarity). In kidney, contributes to the reabsorption of water, helping the body maintain proper fluid balance (By similarity)

Subcellular Localization：Cell membrane; Multi-pass membrane protein; Basolateral cell membrane; Multi-pass membrane protein

Expression：
Tissue_specificity:Widely expressed in epithelial cells of kidney (collecting ducts) and airways, in keratinocytes, immature dendritic cells and erytH2O2ytes. Isoform 2 is not detectable in erytH2O2ytes at the protein level

Induction:Up-regulated by magnesium

Isoforms & Post-Translational Modification：Q92482 has 2 isomers: Q92482-1: 31544 Da (predicted); Q92482-2: 29987 Da (predicted).

Subunit：Homotetramer; each monomer provides an independent glycerol/water pore (By similarity). Could also exist in other oligomeric states (PubMed:11751877)

Research Field

Cell Biology

Synonyms

Aquaporin 3; AQP-3; Aquaglyceroporin-3; AQP3

Documentation

User Guide for Antibodies (1077 KB)