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Cat. No.: HY-157979

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AQP3-IN-1

AQP3-IN-1 (compounds 3) is an AQP3 inhibitor with a IC₅₀ value of 8.91 μM. AQP3-IN-1 inhibits cell proliferation of melanoma cells.

For research use only. We do not sell to patients.

CAS No.: 198711-19-2
Formula: C₁₁H₉AuCl₂N₂
Molecular Weight:437.08

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

AQP3-IN-1 Chemical Structure

CAS No.: 198711-19-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

AQP3-IN-1 (compounds 3) is an AQP3 inhibitor with a IC₅₀ value of 8.91 μM. AQP3-IN-1 inhibits cell proliferation of melanoma cells^[1].

IC₅₀ & Target

AQP3

8.91 μM (IC₅₀)

In Vitro

AQP3-IN-1 (compound 3) (5 μM, 30 min) inhibits cell permeability and glycerol permeability of erythrocytes overexpressing AQP3, but does not affect their water permeability^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

MNT-1, A375 and HEK-293T
Concentration:

2.5-10 μM
Incubation Time:

24 h
Result:

Had no toxic effect on MNT-1 and A375 cells and did not affect cell viability.

Cell Migration Assay ^[1]

Cell Line:

MNT-1, A375
Concentration:

5 μM
Incubation Time:

0, 9, 24 h
Result:

Inhibited melanoma cell adhesion, proliferation, and migration.

Chemical Information

CAS No. 198711-19-2
Molecular Weight 437.08
Formula C₁₁H₉AuCl₂N₂
SMILES

[Cl-][Au+3]1([C-]2=C(NC3=[N]1C=CC=C3)C=CC=C2)[Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Rodrigues C, et al. Human Aquaporin-5 Facilitates Hydrogen Peroxide Permeation Affecting Adaption to Oxidative Stress and Cancer Cell Migration. Cancers (Basel). 2019 Jul 3;11(7):932.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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