VASN - vasorin Gene

Also Known as SLITL2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 114990

About VASN

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:4,371,848-4,383,538 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 255 orthologues and 22 paralogues. Broad expression in placenta (RPKM 16.9), kidney (RPKM 16.4) and 24 other tissues.

Summary

Enables transforming growth factor beta binding activity. Involved in negative regulation of epithelial to mesenchymal transition and negative regulation of transforming growth factor beta receptor signaling pathway. Located in cell surface and extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

VASN Products (1)

mRNA Protein Name
NM_138440.3 NP_612449.2 vasorin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables transforming growth factor beta binding IPI
IPI: Inferred from physical interaction
15247411 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
21170088 GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
15247411 GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
21170088 GOA
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
15247411 GOA
located in extracellular exosome IDA
IDA: Inferred from direct assay
21082674 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
15247411 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VASN Protein Structure

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (23 - 51)

LRR_1

LRR_1: Leucine Rich Repeat (78 - 98)

LRR_8

LRR_8: Leucine rich repeat (101 - 160)

LRR_8

LRR_8: Leucine rich repeat (193 - 249)

  • 0
  • 200
  • 400
  • 600
  • 673 a.a.
Protein Preferred Names Protein Names

vasorin

  • protein slit-like 2

VASN Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
VASN Q6EMK4 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 KRTAP10-7 Homo sapiens P60409
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP4-2 Homo sapiens Q9BYR5
Validated Y2H
32296183
Intra
VASN Q6EMK4 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 ADAMTSL4 Homo sapiens Q6UY14-3
Validated Y2H
32296183
Intra
VASN Q6EMK4 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP12-2 Homo sapiens P59991
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 KRTAP12-2 Homo sapiens P59991
Y2H Array
32296183
Intra
VASN Q6EMK4 RGS20 Homo sapiens O76081-6
Y2H Array
32296183
Intra
VASN Q6EMK4 RGS20 Homo sapiens O76081-6
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 RNF31 Homo sapiens Q96EP0-3
Validated Y2H
25416956
Intra
VASN Q6EMK4 RNF31 Homo sapiens Q96EP0-3
Y2H Array
25416956
Intra
VASN Q6EMK4 LCE2D Homo sapiens Q5TA82
Y2H Array
32296183
Intra
VASN Q6EMK4 LCE2D Homo sapiens Q5TA82
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 KRTAP4-11 Homo sapiens Q9BYQ6
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 KRTAP4-11 Homo sapiens Q9BYQ6
Validated Y2H
32296183
Intra
VASN Q6EMK4 KRTAP4-11 Homo sapiens Q9BYQ6
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP9-3 Homo sapiens Q9BYQ3
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 KRTAP9-3 Homo sapiens Q9BYQ3
Validated Y2H
32296183
Intra
VASN Q6EMK4 KRTAP9-3 Homo sapiens Q9BYQ3
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP11-1 Homo sapiens Q8IUC1
Validated Y2H
32296183
Intra
VASN Q6EMK4 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP12-3 Homo sapiens P60328
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 KRTAP12-3 Homo sapiens P60328
Y2H Array
32296183
Intra
VASN Q6EMK4 VWC2 Homo sapiens Q2TAL6
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 VWC2 Homo sapiens Q2TAL6
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP9-8 Homo sapiens Q9BYQ0
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 KRTAP9-8 Homo sapiens Q9BYQ0
Validated Y2H
32296183
Intra
VASN Q6EMK4 KRTAP9-8 Homo sapiens Q9BYQ0
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 ZNF837 Homo sapiens Q96EG3
Validated Y2H
32296183
Intra
VASN Q6EMK4 LCE2C Homo sapiens Q5TA81
Y2H Array
32296183
Intra
VASN Q6EMK4 LCE2C Homo sapiens Q5TA81
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 GUCD1 Homo sapiens Q96NT3-2
Validated Y2H
32296183
Intra
VASN Q6EMK4 KRTAP17-1 Homo sapiens Q9BYP8
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 KRTAP17-1 Homo sapiens Q9BYP8
Validated Y2H
32296183
Intra
VASN Q6EMK4 KRTAP17-1 Homo sapiens Q9BYP8
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP5-11 Homo sapiens Q6L8G4
Validated Y2H
32296183
Intra
VASN Q6EMK4 KRTAP10-6 Homo sapiens P60371
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 KRTAP10-6 Homo sapiens P60371
Y2H Array
32296183
Intra
VASN Q6EMK4 CELF5 Homo sapiens Q8N6W0
Validated Y2H
32296183
Intra
VASN Q6EMK4 LCE1C Homo sapiens Q5T751
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 LCE1C Homo sapiens Q5T751
Y2H Array
32296183
Intra
VASN Q6EMK4 CIB4 Homo sapiens A0PJX0
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 CIB4 Homo sapiens A0PJX0
Y2H Array
32296183
Intra
VASN Q6EMK4 NR4A3 Homo sapiens Q92570
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 NR4A3 Homo sapiens Q92570
Validated Y2H
32296183
Intra
VASN Q6EMK4 NR4A3 Homo sapiens Q92570
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP2-4 Homo sapiens Q9BYR9
Validated Y2H
32296183
Intra
VASN Q6EMK4 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
VASN Q6EMK4 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
VASN Q6EMK4 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 TGM1 Homo sapiens P22735
Y2H Array
32296183
Intra
VASN Q6EMK4 TGM1 Homo sapiens P22735
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 AQP3 Homo sapiens Q92482
Validated Y2H
32296183
Intra
VASN Q6EMK4 KRTAP4-1 Homo sapiens Q9BYQ7
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 KRTAP4-1 Homo sapiens Q9BYQ7
Y2H Array
32296183
Intra
VASN Q6EMK4 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
VASN Q6EMK4 RGS17 Homo sapiens Q9UGC6
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 RGS17 Homo sapiens Q9UGC6
Validated Y2H
32296183
Intra
VASN Q6EMK4 RGS17 Homo sapiens Q9UGC6
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP26-1 Homo sapiens Q6PEX3
Validated Y2H
32296183
Intra
VASN Q6EMK4 KRTAP26-1 Homo sapiens Q6PEX3
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP26-1 Homo sapiens Q6PEX3
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra
VASN Q6EMK4 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
VASN Q6EMK4 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
VASN Q6EMK4 ZNF417 Homo sapiens Q8TAU3
Validated Y2H
32296183
Intra
VASN Q6EMK4 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 HOXA1 Homo sapiens P49639
Y2H Array
32296183
Intra
VASN Q6EMK4 TRIP6 Homo sapiens Q15654
Y2H Array
32296183
Intra
VASN Q6EMK4 TRIP6 Homo sapiens Q15654
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 SMCP Homo sapiens P49901
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 SMCP Homo sapiens P49901
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 KRTAP3-2 Homo sapiens Q9BYR7
Validated Y2H
32296183
Intra
VASN Q6EMK4 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Array
32296183
Intra
VASN Q6EMK4 RGS19 Homo sapiens P49795
Y2H Array
32296183
Intra
VASN Q6EMK4 RGS19 Homo sapiens P49795
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra
VASN Q6EMK4 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
VASN Q6EMK4 KRTAP3-1 Homo sapiens Q9BYR8
Validated Y2H
32296183
Intra
VASN Q6EMK4 KRTAP3-1 Homo sapiens Q9BYR8
Y2H Array
32296183
Intra
VASN Q6EMK4 KRTAP3-1 Homo sapiens Q9BYR8
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant VASN Proteins

Cat. No. Product Name Accession Purity
HY-P70999 Vasorin Protein, Human (552a.a, HEK293, His) Q6EMK4/AAH68575.1 (C24-P575, E384A) ≥ 95%, as determined by reducing SDS-PAGE.

VASN Antibodies

Cat. No. Product Name Application Reactivity
HY-P810157 Vasorin Antibody (YA9501) WB, ELISA human

Related Diseases

Diseases Alias
Hematuria, Benign Familial

  • Benign Familial Hematuria

  • BFH

  • Thin Membrane Nephropathy

  • Tmn

  • Thin Basement Membrane Nephropathy

  • Thin-Basement-Membrane Nephropathy

  • Hematuria, Familial Benign

  • Hematuria Benign Familial

  • Hematuria, Benign, Familial

  • Thin Basement Membrane Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15608 VASN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18980 Vasn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25469 Vasn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus VASN MGD MGI:2177651
Canis familiaris VASN VGNC VGNC:54089
Rattus norvegicus VASN RGD RGD:1598149
Felis catus VASN VGNC VGNC:66921
Others VASN NCBI