RGS19 - regulator of G protein signaling 19 Gene

Homo sapiens

Also known as GAIP; RGSGAIP

Gene ID: 10287 | Gene type: protein coding

About RGS19

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:64,073,181-64,079,964 (from NCBI)

This gene has 4 transcripts (splice variants), 184 orthologues and 23 paralogues. Broad expression in spleen (RPKM 10.5), bone marrow (RPKM 8.6) and 21 other tissues.

Summary

G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]

RGS19 Products(7)

mRNA	Protein	Name
XM_005260182.4	XP_005260239.1	regulator of G-protein signaling 19 isoform X3
NM_001039467.2	NP_001034556.1	regulator of G-protein signaling 19
NM_005873.3	NP_005864.1	regulator of G-protein signaling 19
XM_011528484.3	XP_011526786.1	regulator of G-protein signaling 19 isoform X1
XM_011528485.3	XP_011526787.1	regulator of G-protein signaling 19 isoform X2
XM_047439824.1	XP_047295780.1	regulator of G-protein signaling 19 isoform X2
XM_005260183.3	XP_005260240.1	regulator of G-protein signaling 19 isoform X3

RGS19 Protein Structure

RGS

0
100
200
217 a.a.

Protein Preferred Names

Protein Names

regulator of G-protein signaling 19

G alpha interacting protein	G protein signalling regulator 19
guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein	regulator of G-protein signalling 19

Related Diseases

Diseases

Alias

Deafness, Autosomal Recessive 15

DFNB15	Dfnb72
Dfnb95	Deafness, Autosomal Recessive 72
Autosomal Recessive Nonsyndromic Deafness 15	Deafness, Autosomal Recessive 95
Autosomal Recessive Deafness 15	Autosomal Recessive Deafness 72
Autosomal Recessive Deafness 95	Deafness, Autosomal Recessive, 15
Deafness Autosomal Recessive 72	Deafness Autosomal Recessive 95
Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 15	Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 15
Deafness, Autosomal Recessive, Type 15

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13509	CCG-50014	Inhibitor	99.42%	Unkown
HY-U00431	CCG 203769	Inhibitor	99.76%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RGS19	VGNC	VGNC:45528
Felis catus	RGS19	VGNC	VGNC:64594
Rattus norvegicus	RGS19	RGD	RGD:629471
Mus musculus	RGS19	MGD	MGI:1915153
Macaca mulatta	RGS19	VGNC	VGNC:108027
Bos taurus	RGS19	VGNC	VGNC:33918

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