RGS19 - regulator of G protein signaling 19 Gene

Also Known as GAIP; RGSGAIP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10287

About RGS19

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:64,073,181-64,079,964 (from NCBI)

This gene has 4 transcripts (splice variants), 184 orthologues and 23 paralogues. Broad expression in spleen (RPKM 10.5), bone marrow (RPKM 8.6) and 21 other tissues.

Summary

G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]

RGS19 Products (7)

mRNA	Protein	Name
XM_005260182.4	XP_005260239.1	regulator of G-protein signaling 19 isoform X3
NM_001039467.2	NP_001034556.1	regulator of G-protein signaling 19
NM_005873.3	NP_005864.1	regulator of G-protein signaling 19
XM_011528484.3	XP_011526786.1	regulator of G-protein signaling 19 isoform X1
XM_011528485.3	XP_011526787.1	regulator of G-protein signaling 19 isoform X2
XM_047439824.1	XP_047295780.1	regulator of G-protein signaling 19 isoform X2
XM_005260183.3	XP_005260240.1	regulator of G-protein signaling 19 isoform X3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	8524874	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RGS19 Protein Structure

RGS

0
100
200
217 a.a.

Protein Preferred Names	Protein Names
regulator of G-protein signaling 19	G alpha interacting protein G protein signalling regulator 19 guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein regulator of G-protein signalling 19

RGS19 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RGS19	P49795	LCE4A	Homo sapiens	Q5TA78	Validated Y2H	32296183
Intra	RGS19	P49795	VASN	Homo sapiens	Q6EMK4	Validated Y2H	32296183
Intra	RGS19	P49795	KRTAP5-6	Homo sapiens	Q6L8G9	Validated Y2H	32296183
Intra	RGS19	P49795	NUFIP2	Homo sapiens	Q7Z417	Validated Y2H	32296183
Intra	RGS19	P49795	POU4F2	Homo sapiens	Q12837	Validated Y2H	32296183
Intra	RGS19	P49795	CATSPER1	Homo sapiens	Q8NEC5	Validated Y2H	32296183
Cross	RGS19	P49795	Gnai3	Rattus norvegicus	P08753	Y2H	8524874
Cross	RGS19	P49795	Gnai3	Rattus norvegicus	P08753	Pull Down	8524874

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Deafness, Autosomal Recessive 15	DFNB15 Dfnb72 Dfnb95 Deafness, Autosomal Recessive 72 Autosomal Recessive Nonsyndromic Deafness 15 Deafness, Autosomal Recessive 95 Autosomal Recessive Deafness 15 Autosomal Recessive Deafness 72 Autosomal Recessive Deafness 95 Deafness, Autosomal Recessive, 15 Deafness Autosomal Recessive 72 Deafness Autosomal Recessive 95 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 15 Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 15 Deafness, Autosomal Recessive, Type 15

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13509	CCG-50014	Inhibitor	99.62%	Unkown
HY-U00431	CCG 203769	Inhibitor	99.76%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RGS19	VGNC	VGNC:45528
Felis catus	RGS19	VGNC	VGNC:64594
Rattus norvegicus	RGS19	RGD	RGD:629471
Mus musculus	RGS19	MGD	MGI:1915153
Macaca mulatta	RGS19	VGNC	VGNC:108027
Bos taurus	RGS19	VGNC	VGNC:33918
Others	RGS19	NCBI