1. GPCR/G Protein
  2. RGS Protein
  3. CCG-50014

CCG-50014 

Cat. No.: HY-13509
Handling Instructions

CCG-50014 is the most potent against the regulator of G-protein signaling protein type 4 (RGS4) (IC50 =30 nM) and is >20-fold selective for RGS4 over other RGS proteins. CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site. CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test.

For research use only. We do not sell to patients.

CCG-50014 Chemical Structure

CCG-50014 Chemical Structure

CAS No. : 883050-24-6

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Description

CCG-50014 is the most potent against the regulator of G-protein signaling protein type 4 (RGS4) (IC50 =30 nM) and is >20-fold selective for RGS4 over other RGS proteins. CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site[1]. CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test[2].

IC50 & Target[1]

RGS4

30 nM (IC50)

RGS8

11 μM (IC50)

RGS16

3.5 μM (IC50)

RGS19

0.12 μM (IC50)

In Vivo

CCG50014 (10, 30, or 100 nM) attenuates the nociceptive responses during the late phase in a dose-dependent manner[2].

Molecular Weight

316.35

Formula

C₁₆H₁₃FN₂O₂S

CAS No.

883050-24-6

SMILES

O=C(N1CC2=CC=C(F)C=C2)N(C3=CC=C(C)C=C3)SC1=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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CCG-50014
Cat. No.:
HY-13509
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