1. GPCR/G Protein
  2. RGS Protein
  3. CCG-50014

CCG-50014 

Cat. No.: HY-13509 Purity: 99.33%
Handling Instructions

CCG-50014 is the most potent against the regulator of G-protein signaling protein type 4 (RGS4) (IC50 =30 nM) and is >20-fold selective for RGS4 over other RGS proteins. CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site. CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test.

For research use only. We do not sell to patients.

CCG-50014 Chemical Structure

CCG-50014 Chemical Structure

CAS No. : 883050-24-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 59 In-stock
Estimated Time of Arrival: December 31
1 mg USD 50 In-stock
Estimated Time of Arrival: December 31
5 mg USD 85 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

CCG-50014 is the most potent against the regulator of G-protein signaling protein type 4 (RGS4) (IC50 =30 nM) and is >20-fold selective for RGS4 over other RGS proteins. CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site[1]. CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test[2].

IC50 & Target[1]

RGS4

30 nM (IC50)

RGS8

11 μM (IC50)

RGS16

3.5 μM (IC50)

RGS19

0.12 μM (IC50)

In Vivo

CCG50014 (10, 30, or 100 nM) attenuates the nociceptive responses during the late phase in a dose-dependent manner[2].

Molecular Weight

316.35

Formula

C₁₆H₁₃FN₂O₂S

CAS No.

883050-24-6

SMILES

O=C(N1CC2=CC=C(F)C=C2)N(C3=CC=C(C)C=C3)SC1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (197.57 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1611 mL 15.8053 mL 31.6106 mL
5 mM 0.6322 mL 3.1611 mL 6.3221 mL
10 mM 0.3161 mL 1.5805 mL 3.1611 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

CCG-50014CCG50014CCG 50014RGS ProteinRegulators of G-protein SignalingRegulator of G-protein SignalingInhibitorinhibitorinhibit

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Product Name:
CCG-50014
Cat. No.:
HY-13509
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