1. GPCR/G Protein
  2. RGS Protein
  3. CCG-50014

CCG-50014 

Cat. No.: HY-13509
Handling Instructions

CCG-50014 is a G-Protein signaling (RGS) protein 4 inhibitor (IC50 =30 nM) and is >20-fold selective for RGS4 over other RGS proteins. CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site. CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test.

For research use only. We do not sell to patients.

CCG-50014 Chemical Structure

CCG-50014 Chemical Structure

CAS No. : 883050-24-6

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Description

CCG-50014 is a G-Protein signaling (RGS) protein 4 inhibitor (IC50 =30 nM) and is >20-fold selective for RGS4 over other RGS proteins. CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site[1]. CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test[2].

IC50 & Target[1]

RGS4

30 nM (IC50)

In Vivo

CCG50014 (10, 30, or 100 nM) attenuated the nociceptive responses during the late phase in a dose-dependent manner[2].

Molecular Weight

316.35

Formula

C₁₆H₁₃FN₂O₂S

CAS No.

883050-24-6

SMILES

O=C(N1CC2=CC=C(F)C=C2)N(C3=CC=C(C)C=C3)SC1=O

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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CCG-50014
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HY-13509
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