SGPL1 - sphingosine-1-phosphate lyase 1 Gene

Also Known as SPL; S1PL; NPHS14

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8879

About SGPL1

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:70,815,948-70,881,184 (from NCBI)

This gene has 18 transcripts (splice variants), 212 orthologues, 7 paralogues and is associated with 2 phenotypes. Ubiquitous expression in urinary bladder (RPKM 14.9), skin (RPKM 13.8) and 25 other tissues.

Summary

Enables sphinganine-1-phosphate aldolase activity. Involved in apoptotic signaling pathway; fatty acid metabolic process; and sphingolipid metabolic process. Located in endoplasmic reticulum. Implicated in nephrotic syndrome type 14. [provided by Alliance of Genome Resources, Apr 2022]

SGPL1 Products (1)

mRNA	Protein	Name
NM_003901.4	NP_003892.2	sphingosine-1-phosphate lyase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21903422	GOA
enables sphinganine-1-phosphate aldolase activity	IDA IDA: Inferred from direct assay	14570870	GOA
enables sphinganine-1-phosphate aldolase activity	IMP IMP: Inferred from mutant phenotype	28165339	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in apoptotic signaling pathway	IDA IDA: Inferred from direct assay	14570870	GOA
involved in ceramide metabolic process	IDA IDA: Inferred from direct assay	14570870	GOA
involved in fatty acid metabolic process	IDA IDA: Inferred from direct assay	24809814	GOA
involved in sphingolipid catabolic process	IDA IDA: Inferred from direct assay	24809814	GOA
involved in sphingolipid catabolic process	IMP IMP: Inferred from mutant phenotype	28165339	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	14570870	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SGPL1 Protein Structure

Pyridoxal_deC

0
100
200
300
400
500
568 a.a.

Protein Preferred Names	Protein Names
sphingosine-1-phosphate lyase 1	SP-lyase 1

SGPL1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SGPL1	O95470	RTP2	Homo sapiens	Q5QGT7	Validated Y2H	32296183
Intra	SGPL1	O95470	CCL4L1	Homo sapiens	Q8NHW4	Validated Y2H	32296183
Intra	SGPL1	O95470	SLC30A3	Homo sapiens	Q99726	Validated Y2H	32296183
Intra	SGPL1	O95470	TMEM242	Homo sapiens	Q9NWH2	Validated Y2H	32296183
Intra	SGPL1	O95470	PAQR5	Homo sapiens	Q9NXK6	Y2H Prey Pooling	32296183
Intra	SGPL1	O95470	PAQR5	Homo sapiens	Q9NXK6	Validated Y2H	32296183
Intra	SGPL1	O95470	PLPP4	Homo sapiens	Q5VZY2	Y2H Array	32296183
Intra	SGPL1	O95470	PLPP4	Homo sapiens	Q5VZY2	Validated Y2H	32296183
Intra	SGPL1	O95470	FA2H	Homo sapiens	Q7L5A8	Validated Y2H	32296183
Intra	SGPL1	O95470	TMEM97	Homo sapiens	Q5BJF2	Validated Y2H	32296183
Intra	SGPL1	O95470	FXYD3	Homo sapiens	Q14802-3	Validated Y2H	32296183
Intra	SGPL1	O95470	FAM177A1	Homo sapiens	Q8N128-2	Validated Y2H	32296183
Intra	SGPL1	O95470	BRICD5	Homo sapiens	Q6PL45-2	Validated Y2H	32296183
Intra	SGPL1	O95470	CLDN19	Homo sapiens	Q8N6F1-2	Validated Y2H	32296183
Intra	SGPL1	O95470	RNASE10	Homo sapiens	Q5GAN6	Validated Y2H	32296183
Intra	SGPL1	O95470	MMD2	Homo sapiens	Q8IY49-2	Validated Y2H	32296183
Intra	SGPL1	O95470	EFNA5	Homo sapiens	P52803	Validated Y2H	32296183
Intra	SGPL1	O95470	MARCHF5	Homo sapiens	Q9NX47	Validated Y2H	32296183
Intra	SGPL1	O95470	SCAMP5	Homo sapiens	Q8TAC9	Validated Y2H	32296183
Intra	SGPL1	O95470	TMEM176A	Homo sapiens	Q96HP8	Validated Y2H	32296183
Intra	SGPL1	O95470	AQP3	Homo sapiens	Q92482	Validated Y2H	32296183
Intra	SGPL1	O95470	MFSD6	Homo sapiens	Q6ZSS7	Validated Y2H	32296183
Intra	SGPL1	O95470	PLP2	Homo sapiens	Q04941	Validated Y2H	32296183
Intra	SGPL1	O95470	BCL2L2	Homo sapiens	Q92843	Validated Y2H	32296183
Intra	SGPL1	O95470	ERG28	Homo sapiens	Q9UKR5	Validated Y2H	32296183
Intra	SGPL1	O95470	HMOX2	Homo sapiens	P30519	Validated Y2H	32296183
Intra	SGPL1	O95470	STX8	Homo sapiens	Q9UNK0	Validated Y2H	32296183
Intra	SGPL1	O95470	STATH	Homo sapiens	P02808	Validated Y2H	32296183
Intra	SGPL1	O95470	STX4	Homo sapiens	Q12846	Validated Y2H	32296183
Intra	SGPL1	O95470	UNC50	Homo sapiens	Q53HI1	Validated Y2H	32296183
Intra	SGPL1	O95470	IFITM3	Homo sapiens	Q01628	Validated Y2H	32296183
Intra	SGPL1	O95470	MIP	Homo sapiens	P30301	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Nephrotic Syndrome, Type 14	Sphingosine Phosphate Lyase Insufficiency Syndrome Nephrotic Syndrome 14 NPHS14 Splis Nephrotic Syndrome Type 14 Sgpl1 Deficiency Steroid-Resistant Nephrotic Syndrome Type 14 Familial Steroid-Resistant Nephrotic Syndrome With Adrenal Insufficiency Primary Adrenal Insufficiency-Steroid-Resistant Nephrotic Syndrome Due To Sgpl1 Deficiency
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies
Nephrotic Syndrome	Finnish Congenital Nephrotic Syndrome Ns - [Nephrotic Syndrome] Nephrosis Syndrome Nephrosis Nos Glomerular Lesion Nephrosis
Ichthyosis	Ichthyoses Non-Syndromic Ichthyosis Congenital Ichthyosis
Focal Segmental Glomerulosclerosis	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Focal Glomerulosclerosis Fsgs Segmental Glomerulosclerosis Glomerulosclerosis, Focal Segmental Fgs Focal Glomerular Sclerosis Familial Idiopathic Nephrotic Syndrome Focal Sclerosis With Hyalinosis Glomerulosclerosis, Focal Glomerulosclerosis Focal Glomerulosclerosis, Segmental, Focal Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Niemann-Pick Disease, Type B	Niemann-Pick Disease Type B Acid Sphingomyelinase Deficiency, Visceral Type Asmd, Visceral Type Niemann Pick Disease Type B Chronic Visceral Acid Sphingomyelinase Deficiency Chronic Visceral Asmd Npd-B Niemann-Pick Disease B NPDB Niemann-Pick Disease Adult Non-Neuronopathic Form Niemann-Pick Disease Intermediate With Visceral Involvement And Rapid Progression Niemann-Pick Disease Type E Niemann-Pick Disease Type F Niemann-Pick Disease Type I Niemann-Pick Disease Visceral Form Npb Sphingomyelinase Deficiency Sphingomyelin Lipidosis Niemann-Picks Disease Type B Niemann-Pick Disease, Type E Niemann-Pick Diseases Niemann-Pick Disease, Type A
Achalasia-Addisonianism-Alacrima Syndrome	Allgrove Syndrome Triple-A Syndrome Achalasia-Addisonianism-Alacrimia Syndrome Alacrima-Achalasia-Adrenal Insufficiency Neurologic Disorder Triple A Syndrome Aaa Syndrome AAAS Glucocorticoid Deficiency With Achalasia Glucocorticoid Deficiency And Achalasia Addisonian-Achalasia Syndrome Hypoadrenalism With Achalasia Alacrima-Achalasia-Addisonianism Aaa Acth-Resistant Adrenal Insufficiency, Achalasia And Alacrima Achalasia Addisonianism Alacrimia Syndrome Achalasia Alacrima Syndrome Addisonian Achalasia Syndrome Achalasia-Addisonian Syndrome Achalasia-Alacrima Syndrome 2a Syndrome 3a Syndrome 4a Syndrome Adrenal Insufficiency-Achalasia-Alacrima Syndrome Double A Syndrome Quaternary A Syndrome Acth-Resistant Adrenal Insufficiency With Achalasia And Alacrima Allgrove'S Syndrome Adrenal Gland Hypofunction Adrenal Cortical Hypofunction
Familial Glucocorticoid Deficiency	Glucocorticoid Deficiency Acth Resistance Adrenal Unresponsiveness To Acth Hereditary Unresponsiveness To Adrenocorticotropic Hormone Isolated Glucocorticoid Deficiency Glucocorticoid Deficiency, Familial Glucocorticoid Deficiency 1
Galloway-Mowat Syndrome	Galloway Mowat Syndrome Galloway Syndrome Hiatal Hernia-Microcephaly-Nephrosis, Galloway Type Microcephaly Nephrosis Syndrome Microcephaly, Hiatal Hernia, And Nephrotic Syndrome Nephrosis Neuronal Dysmigration Syndrome Microcephaly-Hiatus Hernia-Nephrotic Syndrome Nephrosis-Neuronal Dysmigration Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-D2284	SGPL1 fluorogenic substrate		98.81%	Unkown
HY-RS12809	SGPL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21755	Sgpl1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28273	Sgpl1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SGPL1	VGNC	VGNC:46102
Bos taurus	SGPL1	VGNC	VGNC:34547
Macaca mulatta	SGPL1	VGNC	VGNC:77196
Felis catus	SGPL1	VGNC	VGNC:65083
Rattus norvegicus	SGPL1	RGD	RGD:628599
Mus musculus	SGPL1	MGD	MGI:1261415
Others	SGPL1	NCBI