MIP - major intrinsic protein of lens fiber Gene

Also Known as AQP0; LIM1; MP26; MIP26; CTRCT15

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4284

About MIP

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:56,449,502-56,456,553 (from NCBI)

This gene has 4 transcripts (splice variants), 271 orthologues, 11 paralogues and is associated with 8 phenotypes. Low expression observed in reference dataset.

Summary

Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13. [provided by RefSeq, Jul 2008]

MIP Products (1)

mRNA	Protein	Name
NM_012064.4	NP_036196.1	lens fiber major intrinsic protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables water channel activity	IDA IDA: Inferred from direct assay	24120416	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in gap junction-mediated intercellular transport	IDA IDA: Inferred from direct assay	24120416	GOA
involved in positive regulation of cell adhesion	IDA IDA: Inferred from direct assay	24120416	GOA
involved in protein homotetramerization	IDA IDA: Inferred from direct assay	24120416	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	24120416	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	24120416	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MIP Protein Structure

MIP

0
100
200
263 a.a.

Protein Preferred Names	Protein Names
lens fiber major intrinsic protein	aquaporin 0

MIP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	MIP	P30301	FKBP1A	Homo sapiens	Q0VDC6	Validated Y2H	32814053
Intra	MIP	P30301	FKBP1A	Homo sapiens	Q0VDC6	Y2H Pooling	32814053
Intra	MIP	P30301	FKBP1A	Homo sapiens	Q0VDC6	Y2H Array	32814053
Intra	MIP	P30301	RELL2	Homo sapiens	Q8NC24	Y2H Array	32296183
Intra	MIP	P30301	RELL2	Homo sapiens	Q8NC24	Y2H Prey Pooling	32296183
Intra	MIP	P30301	RELL2	Homo sapiens	Q8NC24	Validated Y2H	32296183
Intra	MIP	P30301	MRM3	Homo sapiens	Q9HC36	Validated Y2H	32296183
Intra	MIP	P30301	MRM3	Homo sapiens	Q9HC36	Y2H Array	32296183
Intra	MIP	P30301	MRM3	Homo sapiens	Q9HC36	Y2H Prey Pooling	32296183
Intra	MIP	P30301	CISD2	Homo sapiens	Q8N5K1	Y2H Prey Pooling	32296183
Intra	MIP	P30301	CISD2	Homo sapiens	Q8N5K1	Validated Y2H	32296183
Intra	MIP	P30301	CISD2	Homo sapiens	Q8N5K1	Y2H Array	32296183
Intra	MIP	P30301	SGPL1	Homo sapiens	O95470	Y2H Array	32296183
Intra	MIP	P30301	SGPL1	Homo sapiens	O95470	Y2H Prey Pooling	32296183
Intra	MIP	P30301	SYAP1	Homo sapiens	Q96A49	Validated Y2H	32296183
Intra	MIP	P30301	SYAP1	Homo sapiens	Q96A49	Y2H Array	32296183
Intra	MIP	P30301	SYAP1	Homo sapiens	Q96A49	Y2H Prey Pooling	32296183
Intra	MIP	P30301	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	MIP	P30301	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	MIP	P30301	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	MIP	P30301	MFF	Homo sapiens	Q9GZY8-5	Y2H Array	32296183
Intra	MIP	P30301	MFF	Homo sapiens	Q9GZY8-5	Y2H Prey Pooling	32296183
Intra	MIP	P30301	MFF	Homo sapiens	Q9GZY8-5	Validated Y2H	32296183
Intra	MIP	P30301	STX2	Homo sapiens	P32856-2	Y2H Prey Pooling	32296183
Intra	MIP	P30301	STX2	Homo sapiens	P32856-2	Validated Y2H	32296183
Intra	MIP	P30301	STX2	Homo sapiens	P32856-2	Y2H Array	32296183
Intra	MIP	P30301	KCNJ6	Homo sapiens	P48051	Y2H Array	32296183
Intra	MIP	P30301	KCNJ6	Homo sapiens	P48051	Y2H Prey Pooling	32296183
Intra	MIP	P30301	KCNJ6	Homo sapiens	P48051	Validated Y2H	32296183
Intra	MIP	P30301	TMEM154	Homo sapiens	Q6P9G4	Validated Y2H	32296183
Intra	MIP	P30301	TMEM154	Homo sapiens	Q6P9G4	Y2H Array	32296183
Intra	MIP	P30301	TMEM154	Homo sapiens	Q6P9G4	Y2H Prey Pooling	32296183
Intra	MIP	P30301	TM4SF18	Homo sapiens	Q96CE8	Y2H Prey Pooling	32296183
Intra	MIP	P30301	TM4SF18	Homo sapiens	Q96CE8	Validated Y2H	32296183
Intra	MIP	P30301	TM4SF18	Homo sapiens	Q96CE8	Y2H Array	32296183
Intra	MIP	P30301	FCGR2A	Homo sapiens	P12318-2	Y2H Prey Pooling	32296183
Intra	MIP	P30301	FCGR2A	Homo sapiens	P12318-2	Y2H Array	32296183
Intra	MIP	P30301	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	MIP	P30301	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	MIP	P30301	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	MIP	P30301	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	MIP	P30301	SSMEM1	Homo sapiens	Q8WWF3	Validated Y2H	32296183
Intra	MIP	P30301	AQP9	Homo sapiens	O43315	Y2H Array	32296183
Intra	MIP	P30301	AQP9	Homo sapiens	O43315	Y2H Prey Pooling	32296183
Intra	MIP	P30301	SLC18A1	Homo sapiens	P54219-3	Y2H Array	32296183
Intra	MIP	P30301	SLC18A1	Homo sapiens	P54219-3	Y2H Prey Pooling	32296183
Intra	MIP	P30301	SLC18A1	Homo sapiens	P54219-3	Validated Y2H	32296183
Intra	MIP	P30301	ERVFRD-1	Homo sapiens	P60508	Y2H Prey Pooling	32296183
Intra	MIP	P30301	ERVFRD-1	Homo sapiens	P60508	Validated Y2H	32296183
Intra	MIP	P30301	ERVFRD-1	Homo sapiens	P60508	Y2H Array	32296183
Intra	MIP	P30301	TMEM52B	Homo sapiens	Q4KMG9	Y2H Prey Pooling	32296183
Intra	MIP	P30301	TMEM52B	Homo sapiens	Q4KMG9	Validated Y2H	32296183
Intra	MIP	P30301	TMEM52B	Homo sapiens	Q4KMG9	Y2H Array	32296183
Intra	MIP	P30301	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	MIP	P30301	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	MIP	P30301	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	MIP	P30301	CLDN5	Homo sapiens	O00501	Y2H Prey Pooling	32296183
Intra	MIP	P30301	CLDN5	Homo sapiens	O00501	Y2H Array	32296183
Intra	MIP	P30301	AMIGO1	Homo sapiens	Q86WK6	Validated Y2H	32296183
Intra	MIP	P30301	AMIGO1	Homo sapiens	Q86WK6	Y2H Array	32296183
Intra	MIP	P30301	AMIGO1	Homo sapiens	Q86WK6	Y2H Prey Pooling	32296183
Intra	MIP	P30301	SLC14A1	Homo sapiens	Q13336-2	Y2H Prey Pooling	32296183
Intra	MIP	P30301	SLC14A1	Homo sapiens	Q13336-2	Validated Y2H	32296183
Intra	MIP	P30301	SLC14A1	Homo sapiens	Q13336-2	Y2H Array	32296183
Intra	MIP	P30301	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
Intra	MIP	P30301	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	32296183
Intra	MIP	P30301	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183
Intra	MIP	P30301	LRP10	Homo sapiens	Q7Z4F1	Y2H Prey Pooling	32296183
Intra	MIP	P30301	LRP10	Homo sapiens	Q7Z4F1	Validated Y2H	32296183
Intra	MIP	P30301	LRP10	Homo sapiens	Q7Z4F1	Y2H Array	32296183
Intra	MIP	P30301	ATP6V0B	Homo sapiens	Q99437	Y2H Prey Pooling	32296183
Intra	MIP	P30301	ATP6V0B	Homo sapiens	Q99437	Y2H Array	32296183
Intra	MIP	P30301	ATP6V0B	Homo sapiens	Q99437	Validated Y2H	32296183
Intra	MIP	P30301	GJB5	Homo sapiens	O95377	Y2H Array	32296183
Intra	MIP	P30301	GJB5	Homo sapiens	O95377	Y2H Prey Pooling	32296183
Intra	MIP	P30301	SAR1A	Homo sapiens	Q9NR31	Y2H Prey Pooling	32296183
Intra	MIP	P30301	SAR1A	Homo sapiens	Q9NR31	Validated Y2H	32296183
Intra	MIP	P30301	SAR1A	Homo sapiens	Q9NR31	Y2H Array	32296183
Intra	MIP	P30301	LRRC4C	Homo sapiens	Q9HCJ2	Validated Y2H	32296183
Intra	MIP	P30301	LRRC4C	Homo sapiens	Q9HCJ2	Y2H Array	32296183
Intra	MIP	P30301	LRRC4C	Homo sapiens	Q9HCJ2	Y2H Prey Pooling	32296183
Intra	MIP	P30301	SYT1	Homo sapiens	P21579	Y2H Array	32296183
Intra	MIP	P30301	SYT1	Homo sapiens	P21579	Y2H Prey Pooling	32296183
Intra	MIP	P30301	CD40	Homo sapiens	P25942	Y2H Array	32296183
Intra	MIP	P30301	CD40	Homo sapiens	P25942	Y2H Prey Pooling	32296183
Intra	MIP	P30301	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	MIP	P30301	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	MIP	P30301	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	MIP	P30301	GOLM1	Homo sapiens	Q8NBJ4	Y2H Array	32296183
Intra	MIP	P30301	GOLM1	Homo sapiens	Q8NBJ4	Y2H Prey Pooling	32296183
Intra	MIP	P30301	GOLM1	Homo sapiens	Q8NBJ4	Validated Y2H	32296183
Intra	MIP	P30301	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	MIP	P30301	STX1A	Homo sapiens	Q16623	Validated Y2H	32296183
Intra	MIP	P30301	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	MIP	P30301	PDZK1IP1	Homo sapiens	Q13113	Y2H Array	32296183
Intra	MIP	P30301	PDZK1IP1	Homo sapiens	Q13113	Validated Y2H	32296183
Intra	MIP	P30301	PDZK1IP1	Homo sapiens	Q13113	Y2H Prey Pooling	32296183
Intra	MIP	P30301	TMEM139	Homo sapiens	Q8IV31	Y2H Prey Pooling	32296183
Intra	MIP	P30301	TMEM139	Homo sapiens	Q8IV31	Validated Y2H	32296183
Intra	MIP	P30301	TMEM139	Homo sapiens	Q8IV31	Y2H Array	32296183
Intra	MIP	P30301	MGST3	Homo sapiens	O14880	Y2H Prey Pooling	32296183
Intra	MIP	P30301	MGST3	Homo sapiens	O14880	Y2H Array	32296183
Intra	MIP	P30301	MRPS18B	Homo sapiens	Q9Y676	Validated Y2H	32296183
Intra	MIP	P30301	MRPS18B	Homo sapiens	Q9Y676	Y2H Prey Pooling	32296183
Intra	MIP	P30301	MRPS18B	Homo sapiens	Q9Y676	Y2H Array	32296183
Intra	MIP	P30301	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	MIP	P30301	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	MIP	P30301	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	MIP	P30301	SYT2	Homo sapiens	Q8N9I0	Y2H Prey Pooling	32296183
Intra	MIP	P30301	SYT2	Homo sapiens	Q8N9I0	Validated Y2H	32296183
Intra	MIP	P30301	SYT2	Homo sapiens	Q8N9I0	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cataract 15, Multiple Types	CTRCT15 Cataract 15 Multiple Types Cataract, Type 15, Multiple Types
Cataract 7	Cca1 CTRCT7 Cerulean Cataract Cataract 7, Cerulean Type Cataract, Congenital, Cerulean Type, 1 Cerulean Type Cataract 7 Congenital Cerulean Type Cataract 1 Cataract, Congenital, Blue Dot Type 1 Cataract, Congenital, Cerulean Type 1 Blue-Dot Cataract
Early-Onset Sutural Cataract	Early-Onset Cataract With Y-Shaped Suture Opacities
Early-Onset Posterior Polar Cataract
Early-Onset Lamellar Cataract
Cataract 44	CTRCT44 Total Early-Onset Cataract Cataract 44 And Hypotrichosis Cataract And Hypotrichosis Cataract, Type 44
Early-Onset Nuclear Cataract
Brain Edema	Cerebral Edema Intracranial Swelling Wet Brain
Nephrogenic Diabetes Insipidus	Vasopressin-Resistant Diabetes Insipidus Diabetes Insipidus, Nephrogenic Diabetes Insipidus Nephrogenic Congenital Nephrogenic Diabetes Insipidus Adh Resistant Diabetes Insipidus Diabetes Insipidus Nephrogenic X-Linked Diabetes Insipidus Nephrogenic Type 1 Adh-Resistant Diabetes Insipidus Diabetes Insipidus Renalis Ndi Renal Diabetes Insipidus Familial Nephrogenic Diabetes Antidiuretic-Hormone-Resistant Diabetes Insipidus Adiuretin-Resistant Diabetes Insipidus Ndi - [Nephrogenic Diabetes Insipidus] Diabetes Tenuifluus Adh - [Antidiuretic-Hormone] Resistant Diabetes Insipidus Hereditary Nephrogenic Diabetes Insipidus Familial Nephrogenic Diabetes Insipidus Primary Nephrogenic Diabetes Insipidus
Presbyopia	Subnormal Accommodation Accommodation Insufficiency Of Old Age
Eye Accommodation Disease
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities
Diabetes Insipidus
Hydrarthrosis
Priapism	Mentulagra Priapism, Familial Idiopathic Familial Idiopathic Priapism Pathologic Erection Painful Erection
Meniere Disease	Meniere'S Disease Otogenic Vertigo Ménière Disease Ménière'S Disease Mnire'S Vertigo Auditory Vertigo Aural Vertigo Meniere'S Syndrome Ménière'S Vertigo Primary Endolymphatic Hydrops Menieres Disease Vertigo, Aural Labyrinth Hydrops Labyrinthine Hydrops Labyrinthine Vertigo Ménière Syndrome Ménière Vertigo Idiopathic Endolymphatic Hydrops
Mature Cataract	Total Or Mature Cataract Total, Mature Senile Cataract
Intraocular Pressure Quantitative Trait Locus	Glaucoma IOPQTL Glaucoma, Susceptibility To Postinfectious Glaucoma Glaucoma With Ocular Inflammation Glaucoma Secondary To Eye Inflammation Traumatic Glaucoma Glaucoma With Concussion Of Globe Glaucoma Due To Ocular Trauma Glaucoma Associated With Ocular Trauma Glaucoma Secondary To Drugs
Lens Disease	Lens Diseases
Diabetic Cataract	Cataract - Diabetic
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Inner Ear Disease	Labyrinthine Dysfunction Diseases Of Inner Ear Labyrinthine Disease Abnormality Of The Inner Ear Labyrinth Diseases Labyrinthine Disorder Nonfunctioning Labyrinth Labyrinthine Loss Of Function Labyrinthine Syndrome Labyrinthine Disorder Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-B1829A	Dexamethasone phosphate disodium		99.94%	Yes
HY-B1829AR	Dexamethasone phosphate disodium (Standard)		99.88%	Unkown

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-B0498	Bindarit	Inhibitor	99.59%	Phase 3
HY-B0155	Vicriviroc		/	Phase 3
HY-118962	E913		/	Phase 3
HY-19974	TAK-220		99.95%	Phase 1
HY-P3627	Nagrestipen		/	Phase 1

Pre-clinical Phase

Bioactive Molecules (36)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-156371	MIPS-21335	Inhibitor	99.61%	Unkown
HY-139644	MIPS521	Agonist	98.21%	Unkown
HY-P4191A	Met-RANTES (human) acetate	Antagonist	99.39%	Unkown
HY-P5523A	iE-DAP dihydrochloride		99.72%	Unkown
HY-120265	MIPS-9922	Inhibitor	99.25%	Unkown
HY-123733A	MIP-1095 TFA	Inhibitor	99.76%	Unkown
HY-149650	TLR4 agonist-1	Agonist	/	Unkown
HY-161901	BC-1293	Inhibitor	98.40%	Unkown
HY-N10116A	Calamenene		/	Unkown
HY-P4191	Met-RANTES (human)	Antagonist	/	Unkown
HY-W014081	Ethyl 3-coumarincarboxylate		99.81%	Unkown
HY-B1829	Dexamethasone phosphate		98.89%	Yes
HY-110391	BX-513	Antagonist	/	Unkown
HY-123661	MIPS1455		/	Unkown
HY-123733	MIP-1095	Inhibitor	/	Unkown
HY-129615	MIP-1072	Inhibitor	/	Unkown
HY-149650A	TLR4 agonist-1 TEA	Agonist	/	Unkown
HY-149861	Mip-IN-1	Inhibitor	/	Unkown
HY-15544	CCR1 antagonist 10	Antagonist	/	Unkown
HY-179277	MIPS3526	Agonist	/	Unkown
HY-B0155B	Vicriviroc malate		/	Unkown
HY-P11093	Papiliocin		/	Unkown
HY-P11502	COG112	Inhibitor	/	Unkown
HY-P5523	iE-DAP		/	Unkown
HY-RS08460	MIP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08461	MIPEP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14859	TNPO1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-103360B	trans-J-113863	Antagonist	/	Unkown
HY-168149	Mip-IN-2	Inhibitor	/	Unkown
HY-174744	Human CCR4 mRNA		/	Unkown
HY-B1829R	Dexamethasone phosphate (Standard)		/	Unkown
HY-N10175	Berkeleyacetal C		/	Unkown
HY-RS19300	Mip Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20118	Tnpo1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22639	Mipep Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25791	Mip Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MIP	MGD	MGI:96990
Rattus norvegicus	MIP	RGD	RGD:3090
Felis catus	MIP	VGNC	VGNC:68259
Macaca mulatta	MIP	VGNC	VGNC:74872
Canis familiaris	MIP	VGNC	VGNC:43241
Bos taurus	MIP	VGNC	VGNC:31482
Others	MIP	NCBI