Calamenene 

Calamenene is a sesquiterpene compound. Calamenene promotes dendritic cell maturation, upregulates CD1a, CD80, CD83, CD86, HLA-DR and CCR7 on the cell surface, reduces endocytic activity, enhances T cell-stimulating capacity, drives Th1 polarization through the secretion of IL-12, induces IFN-γ production, decreases IL-4 generation, and triggers intracellular Ca²⁺ mobilization as well as dendritic cell migration towards MIP-3β. Calamenene exerts bacteriostatic and bactericidal growth-inhibitory effects against pathogenic *Vibrio harveyi*. Calamenene can be used in studies related to cancer and bacterial infections^[1][2].

Calamenene (0.1-10 μM; 2 days) dose-dependently upregulates the expression of maturation markers (CD1a, CD80, CD83, CD86, HLA-DR) and reduces the endocytic activity in human monocyte-derived dendritic cells^[1].
Calamenene (10 μM; 2 days) induces the maturation of human monocyte-derived dendritic cells. Following stimulation with CD40-L, these cells secrete high levels of Th1-promoting cytokines IL-12p70 and IL-6, as well as low levels of the anti-inflammatory cytokine IL-10, driving allogeneic naive CD4⁺ T cells to differentiate into Th1 cells that secrete high levels of IFN-γ and low levels of IL-4^[1].
Calamenene (10 μM; 2 days) induces the maturation of human monocyte-derived dendritic cells, upregulates the expression of CCR7, enhances their migratory capacity toward MIP-3β, and exhibits stronger intracellular Ca²⁺ mobilization in response to MIP-3β^[1].
Calamenene (0.1-5.0 µg/mL; 1 h at room temperature, followed by 24 h at 28 °C post-plating) inhibits the growth of Vibrio harveyi MMRF1107, and the bacterial mortality increases in a concentration-dependent manner^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

202.34

C₁₅H₂₂

483-77-2

CC([C@H]1C2=CC(C)=CC=C2[C@H](CC1)C)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Takei M, et al. T-cadinol and calamenene induce dendritic cells from human monocytes and drive Th1 polarization. Eur J Pharmacol. 2006;537(1-3):190-199.  [Content Brief]

  [2]. Limna Mol VP, et al. Inhibition of pathogenic Vibrio harveyi using calamenene, derived from the Indian gorgonian Subergorgia reticulata, and its synthetic analog. 3 Biotech. 2020 Jun;10(6):248.  [Content Brief]