483-77-2
Chemical Structure
Calamenene
- CAS No.: 483-77-2
- Formula:C15H22
- Molecular Weight:202.34
IUPAC Name: methyl 2-(4-fluorophenyl)propanoate
InChIKey: PGTJIOWQJWHTJJ-STQMWFEESA-N
SMILES: CC([C@H]1C2=CC(C)=CC=C2[C@H](CC1)C)C
Biological Activity: Calamenene is a sesquiterpene compound. Calamenene promotes dendritic cell maturation, upregulates CD1a, CD80, CD83, CD86, HLA-DR and CCR7 on the cell surface, reduces endocytic activity, enhances T cell-stimulating capacity, drives Th1 polarization through the secretion of IL-12, induces IFN-γ production, decreases IL-4 generation, and triggers intracellular Ca2+ mobilization as well as dendritic cell migration towards MIP-3β. Calamenene exerts bacteriostatic and bactericidal growth-inhibitory effects against pathogenic *Vibrio harveyi*. Calamenene can be used in studies related to cancer and bacterial infections[1][2].
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Calamenene | Calamenene is a sesquiterpene compound. Calamenene promotes dendritic cell maturation, upregulates CD1a, CD80, CD83, CD86, HLA-DR and CCR7 on the cell surface, reduces endocytic activity, enhances T cell-stimulating capacity, drives Th1 polarization through the secretion of IL-12, induces IFN-γ production, decreases IL-4 generation, and triggers intracellular Ca2+ mobilization as well as dendritic cell migration towards MIP-3β. Calamenene exerts bacteriostatic and bactericidal growth-inhibitory effects against pathogenic *Vibrio harveyi*. Calamenene can be used in studies related to cancer and bacterial infections. | |||||||||||||||||||||
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- [1]. Takei M, et al. T-cadinol and calamenene induce dendritic cells from human monocytes and drive Th1 polarization. Eur J Pharmacol. 2006;537(1-3):190-199. [Content Brief]
- [2]. Limna Mol VP, et al. Inhibition of pathogenic Vibrio harveyi using calamenene, derived from the Indian gorgonian Subergorgia reticulata, and its synthetic analog. 3 Biotech. 2020 Jun;10(6):248. [Content Brief]
Keywords
