2. Metabolic Enzyme/Protease Immunology/Inflammation GPCR/G Protein NF-κB
  3. Apolipoprotein NO Synthase CXCR NF-κB IKK
  4. COG112

COG112 is an antennapedia-linked apoE-mimetic peptide. COG112 attenuates induction of NO production, inhibits CXC chemokines KC and MIP-2. COG112 reduces nuclear translocation of NF-κB. COG112 inhibits phosphorylation of IκB-α and prevents the degradation of IκB-α. COG112 inhibits the inflammatory response to Citrobacter rodentium .

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COG112

COG112 Chemical Structure

CAS No. : 1314623-74-9

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COG112 Related Antibodies

Top Publications Citing Use of Products

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apoE apoB apoA1 apoA2 apoA4 apoC1 apoC2 apoC3

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nNOS iNOS eNOS

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CXCR CXCR1 CXCR2 CXCR3 CXCR4 CXCR7 CXCR6

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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IKK-α IKK-β IKK IKKε TBK1

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Description

COG112 is an antennapedia-linked apoE-mimetic peptide. COG112 attenuates induction of NO production, inhibits CXC chemokines KC and MIP-2. COG112 reduces nuclear translocation of NF-κB. COG112 inhibits phosphorylation of IκB-α and prevents the degradation of IκB-α. COG112 inhibits the inflammatory response to Citrobacter rodentium [1].

IC50 & Target[1]

apoE

 

Molecular Weight

4501.57

Formula

C204H352N72O39S2
CAS No.
Sequence

Ac-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Cys-Leu-Arg-Val-Arg-Leu-Ala-Ser-His-Leu-Arg-Lys-Leu-Arg-Lys-Arg-Leu-Leu-NH2
Sequence Shortening

Ac-RQIKIWFQNRRMKWKKCLRVRLASHLRKLRKRLL-NH2
SMILES

O=C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCSC)C(N[C@@H](CCCCN)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CS)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H](CC6=CNC=N6)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCNC(N)=N)NC(C)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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COG112 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COG1121314623-74-9COG 112COG-112ApolipoproteinNO SynthaseCXCRNF-κBIKKNitric oxide synthasesNOSCXC chemokine receptorsC-X-C motif chemokine receptorsNuclear factor-κBNuclear factor-kappaBIκB kinaseI kappa B kinaseinflammatory responseCitrobacter rodentiumYAMC cellsInhibitorinhibitorinhibit

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