AQP9 - aquaporin 9 Gene

Also Known as SSC1; AQP-9; T17287; HsT17287

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 366

About AQP9

Cytogenetic location: 15q21.3 Genomic coordinates (GRCh38): 15:58,138,169-58,185,911 (from NCBI)

This gene has 4 transcripts (splice variants), 298 orthologues and 11 paralogues. Biased expression in liver (RPKM 174.7), appendix (RPKM 48.0) and 3 other tissues.

Summary

The aquaporins are a family of water-selective membrane channels. This gene encodes a member of a subset of aquaporins called the aquaglyceroporins. This protein allows passage of a broad range of noncharged solutes and also stimulates urea transport and osmotic water permeability. This protein may also facilitate the uptake of glycerol in hepatic tissue . The encoded protein may also play a role in specialized leukocyte functions such as immunological response and bactericidal activity. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

AQP9 Products (3)

mRNA Protein Name
NM_001320635.2 NP_001307564.1 aquaporin-9 isoform 2
NM_001320636.1 NP_001307565.1 aquaporin-9 isoform 3
NM_020980.5 NP_066190.2 aquaporin-9 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glycerol channel activity EXP
EXP: Inferred from Experiment
10564231 GOA
enables glycerol channel activity IDA
IDA: Inferred from direct assay
30420639 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables urea channel activity IMP
IMP: Inferred from mutant phenotype
9514918 GOA
enables water channel activity IDA
IDA: Inferred from direct assay
30420639 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to cAMP IEP
IEP: Inferred from expression pattern
17636236 GOA
involved in glycerol transmembrane transport IDA
IDA: Inferred from direct assay
30420639 GOA
involved in urea transmembrane transport IMP
IMP: Inferred from mutant phenotype
9514918 GOA
involved in water transport IDA
IDA: Inferred from direct assay
30420639 GOA
Cellular Component GO Annotation Evidence References Source
located in intracellular membrane-bounded organelle IDA
IDA: Inferred from direct assay
18718702 GOA
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
9514918 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AQP9 Protein Structure

MIP

MIP: Major intrinsic protein (20 - 262)

  • 0
  • 100
  • 200
  • 295 a.a.
Protein Preferred Names Protein Names

aquaporin-9

  • aquaglyceroporin-9

AQP9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
AQP9 O43315 ADAM33 Homo sapiens Q08AM2
Validated Y2H
32296183
Intra
AQP9 O43315 SLC38A7 Homo sapiens Q9NVC3
Validated Y2H
32296183
Intra
AQP9 O43315 SGPL1 Homo sapiens O95470
Validated Y2H
32296183
Intra
AQP9 O43315 SGPL1 Homo sapiens O95470
Y2H Array
32296183
Intra
AQP9 O43315 SGPL1 Homo sapiens O95470
Y2H Prey Pooling
32296183
Intra
AQP9 O43315 TMED9 Homo sapiens Q9BVK6
Y2H Prey Pooling
32296183
Intra
AQP9 O43315 TMED9 Homo sapiens Q9BVK6
Validated Y2H
32296183
Intra
AQP9 O43315 TMED9 Homo sapiens Q9BVK6
Y2H Array
32296183
Intra
AQP9 O43315 TMEM109 Homo sapiens Q9BVC6
Validated Y2H
32296183
Intra
AQP9 O43315 AIG1 Homo sapiens Q9NVV5-2
Validated Y2H
32296183
Intra
AQP9 O43315 CTXN3 Homo sapiens Q4LDR2
Validated Y2H
32296183
Intra
AQP9 O43315 FXYD3 Homo sapiens Q14802-3
Validated Y2H
32296183
Intra
AQP9 O43315 CLDN19 Homo sapiens Q8N6F1-2
Validated Y2H
32296183
Intra
AQP9 O43315 CPLX4 Homo sapiens Q7Z7G2
Validated Y2H
32296183
Intra
AQP9 O43315 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra
AQP9 O43315 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra
AQP9 O43315 SERINC1 Homo sapiens Q9NRX5
Validated Y2H
32296183
Intra
AQP9 O43315 EMC6 Homo sapiens Q9BV81
Validated Y2H
32296183
Intra
AQP9 O43315 LHFPL5 Homo sapiens Q8TAF8
Validated Y2H
32296183
Intra
AQP9 O43315 HHLA2 Homo sapiens Q9UM44
Y2H Array
32296183
Intra
AQP9 O43315 HHLA2 Homo sapiens Q9UM44
Y2H Prey Pooling
32296183
Intra
AQP9 O43315 HHLA2 Homo sapiens Q9UM44
Validated Y2H
32296183
Intra
AQP9 O43315 GAST Homo sapiens P01350
Validated Y2H
32296183
Intra
AQP9 O43315 PAEP Homo sapiens P09466
Validated Y2H
32296183
Intra
AQP9 O43315 TF Homo sapiens P02787
Validated Y2H
32296183
Intra
AQP9 O43315 APOD Homo sapiens P05090
Validated Y2H
32296183
Intra
AQP9 O43315 IGFBP5 Homo sapiens P24593
Validated Y2H
32296183
Intra
AQP9 O43315 FZD7 Homo sapiens O75084
Validated Y2H
32296183
Intra
AQP9 O43315 MIP Homo sapiens P30301
Validated Y2H
32296183
Intra
AQP9 O43315 CCDC167 Homo sapiens Q9P0B6
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hydrarthrosis
Polyhydramnios
Bilateral Renal Aplasia
Constipation
Psoriasis 11

  • PSORS11

  • Psoriasis Susceptibility 11

  • Psoriasis

  • Psoriasis Vulgaris

  • Psoriasis 11, Susceptibility To

  • Pv
Oligohydramnios

  • Oligohydramnios - Delivered

  • Antepartum Oligohydramnios

  • Delivered Oligohydramnios

  • Oligohydramnios, Antepartum Condition Or Complication

  • Deficient Liquor

  • Oligohydramnios, Unspecified Trimester

  • Reduced Liquor Volume
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-126073 DFP00173 99.46% Unkown
HY-161834 RG100204 Inhibitor 99.50% Unkown
HY-126074 Z433927330 98.20% Unkown
HY-148600 HTS13286 Inhibitor 98.98% Unkown
HY-148823 RF03176 Inhibitor / Unkown
HY-RS00881 AQP9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17944 Aqp9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24415 Aqp9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris AQP9 VGNC VGNC:38021
Rattus norvegicus AQP9 RGD RGD:68433
Bos taurus AQP9 VGNC VGNC:26051
Macaca mulatta AQP9 VGNC VGNC:69996
Mus musculus AQP9 MGD MGI:1891066
Felis catus AQP9 VGNC VGNC:67986
Others AQP9 NCBI