EMC6 - ER membrane protein complex subunit 6 Gene

Homo sapiens

Also known as TMEM93; RAB5IFL

Gene ID: 83460 | Gene type: protein coding

About EMC6

This gene has 2 transcripts (splice variants) and 193 orthologues. Ubiquitous expression in kidney (RPKM 12.0), testis (RPKM 10.6) and 25 other tissues.

Summary

Contributes to membrane insertase activity. Involved in autophagosome assembly; protein insertion into ER membrane by stop-transfer membrane-anchor sequence; and tail-anchored membrane protein insertion into ER membrane. Is integral component of endoplasmic reticulum membrane and integral component of omegasome membrane. Part of EMC complex. [provided by Alliance of Genome Resources, Apr 2022]

EMC6 Products(2)

mRNA	Protein	Name
NM_001014764.3	NP_001014764.1	ER membrane protein complex subunit 6
NM_031298.4	NP_112588.1	ER membrane protein complex subunit 6

EMC6 Protein Structure

Rab5ip

0
100
110 a.a.

Protein Preferred Names

Protein Names

ER membrane protein complex subunit 6

transmembrane protein 93

Related Diseases

Diseases

Alias

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04340	EMC6 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	EMC6	VGNC	VGNC:28466
Rattus norvegicus	EMC6	RGD	RGD:1309231
Canis familiaris	EMC6	VGNC	VGNC:40335
Macaca mulatta	EMC6	VGNC	VGNC:72130
Mus musculus	EMC6	MGD	MGI:1913298
Felis catus	EMC6	VGNC	VGNC:61836