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EMC6 - ER membrane protein complex subunit 6 Gene

Also Known as TMEM93; RAB5IFL

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 83460

About EMC6

This gene has 2 transcripts (splice variants) and 193 orthologues. Ubiquitous expression in kidney (RPKM 12.0), testis (RPKM 10.6) and 25 other tissues.

Summary

Contributes to membrane insertase activity. Involved in autophagosome assembly; protein insertion into ER membrane by stop-transfer membrane-anchor sequence; and tail-anchored membrane protein insertion into ER membrane. Is integral component of endoplasmic reticulum membrane and integral component of omegasome membrane. Part of EMC complex. [provided by Alliance of Genome Resources, Apr 2022]

EMC6 Products (2)

mRNA	Protein	Name
NM_001014764.3	NP_001014764.1	ER membrane protein complex subunit 6
NM_031298.4	NP_112588.1	ER membrane protein complex subunit 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to membrane insertase activity	IMP IMP: Inferred from mutant phenotype	29809151	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22119785	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in autophagosome assembly	IMP IMP: Inferred from mutant phenotype	23182941	GOA
involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence	IDA IDA: Inferred from direct assay	29242231	GOA
involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence	IMP IMP: Inferred from mutant phenotype	29809151	GOA
involved in tail-anchored membrane protein insertion into ER membrane	IDA IDA: Inferred from direct assay	29242231	GOA
involved in tail-anchored membrane protein insertion into ER membrane	IMP IMP: Inferred from mutant phenotype	29242231	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of EMC complex	IDA IDA: Inferred from direct assay	22119785	GOA
part of EMC complex	IPI IPI: Inferred from physical interaction	32439656	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	23182941	GOA
located in membrane	IDA IDA: Inferred from direct assay	22119785	GOA
located in omegasome membrane	IDA IDA: Inferred from direct assay	23182941	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EMC6 Protein Structure

Rab5ip

0
100
110 a.a.

Protein Preferred Names	Protein Names
ER membrane protein complex subunit 6	transmembrane protein 93

EMC6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	EMC6	Q9BV81	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	EMC6	Q9BV81	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	EMC6	Q9BV81	SLC39A2	Homo sapiens	Q9NP94	Validated Y2H	32296183
Intra	EMC6	Q9BV81	SLC39A2	Homo sapiens	Q9NP94	Y2H Array	32296183
Intra	EMC6	Q9BV81	SLC39A2	Homo sapiens	Q9NP94	Y2H Prey Pooling	32296183
Intra	EMC6	Q9BV81	TLCD4	Homo sapiens	Q96MV1	Y2H Prey Pooling	32296183
Intra	EMC6	Q9BV81	TLCD4	Homo sapiens	Q96MV1	Y2H Array	32296183
Intra	EMC6	Q9BV81	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	EMC6	Q9BV81	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	EMC6	Q9BV81	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	EMC6	Q9BV81	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	EMC6	Q9BV81	AQP9	Homo sapiens	O43315	Y2H Prey Pooling	32296183
Intra	EMC6	Q9BV81	AQP9	Homo sapiens	O43315	Y2H Array	32296183
Intra	EMC6	Q9BV81	MMD	Homo sapiens	Q15546	Y2H Prey Pooling	32296183
Intra	EMC6	Q9BV81	MMD	Homo sapiens	Q15546	Y2H Array	32296183
Intra	EMC6	Q9BV81	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	EMC6	Q9BV81	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	EMC6	Q9BV81	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	EMC6	Q9BV81	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	EMC6	Q9BV81	MFSD14B	Homo sapiens	Q5SR56	Y2H Array	32296183
Intra	EMC6	Q9BV81	MFSD14B	Homo sapiens	Q5SR56	Y2H Prey Pooling	32296183
Intra	EMC6	Q9BV81	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	EMC6	Q9BV81	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	EMC6	Q9BV81	SLC7A1	Homo sapiens	P30825	Y2H Array	32296183
Intra	EMC6	Q9BV81	SLC7A1	Homo sapiens	P30825	Y2H Prey Pooling	32296183
Intra	EMC6	Q9BV81	MMGT1	Homo sapiens	Q8N4V1	Y2H Prey Pooling	32296183
Intra	EMC6	Q9BV81	MMGT1	Homo sapiens	Q8N4V1	Y2H Array	32296183
Intra	EMC6	Q9BV81	MMGT1	Homo sapiens	Q8N4V1	Anti Tag CoIP	32439656
Intra	EMC6	Q9BV81	MMGT1	Homo sapiens	Q8N4V1	Anti Tag CoIP	33961781
Intra	EMC6	Q9BV81	PDZK1IP1	Homo sapiens	Q13113	Y2H Array	32296183
Intra	EMC6	Q9BV81	PDZK1IP1	Homo sapiens	Q13113	Y2H Prey Pooling	32296183
Intra	EMC6	Q9BV81	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	EMC6	Q9BV81	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	EMC6	Q9BV81	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	EMC6	Q9BV81	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	EMC6	Q9BV81	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	EMC6	Q9BV81	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	EMC6	Q9BV81	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	EMC6	Q9BV81	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04340	EMC6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22158	Emc6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	EMC6	VGNC	VGNC:28466
Rattus norvegicus	EMC6	RGD	RGD:1309231
Canis familiaris	EMC6	VGNC	VGNC:40335
Macaca mulatta	EMC6	VGNC	VGNC:72130
Mus musculus	EMC6	MGD	MGI:1913298
Felis catus	EMC6	VGNC	VGNC:61836
Others	EMC6	NCBI