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MMD - monocyte to macrophage differentiation associated Gene

Also Known as MMA; MMD1; PAQR11

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23531

About MMD

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:55,392,622-55,421,835 (from NCBI)

This gene has 4 transcripts (splice variants), 217 orthologues and 10 paralogues. Biased expression in fat (RPKM 97.6), brain (RPKM 27.2) and 9 other tissues.

Summary

This protein is expressed by in vitro differentiated macrophages but not freshly isolated monocytes. Although sequence analysis identifies seven potential transmembrane domains, this protein has little homology to G-protein receptors and it has not been positively identified as a receptor. A suggested alternative function is that of an ion channel protein in maturing macrophages. [provided by RefSeq, Jul 2008]

MMD Products (1)

mRNA	Protein	Name
NM_012329.3	NP_036461.2	monocyte to macrophage differentiation factor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	21968647	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in positive regulation of neuron differentiation	IDA IDA: Inferred from direct assay	21968647	GOA
involved in positive regulation of protein kinase activity	IDA IDA: Inferred from direct assay	21968647	GOA
involved in regulation of protein localization	IDA IDA: Inferred from direct assay	21968647	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	21968647	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MMD Protein Structure

HlyIII

0
100
200
238 a.a.

Protein Preferred Names	Protein Names
monocyte to macrophage differentiation factor	macrophage maturation-associated

MMD Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	MMD	Q15546	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	MMD	Q15546	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	MMD	Q15546	ARL13B	Homo sapiens	Q3SXY8	Validated Y2H	32296183
Intra	MMD	Q15546	AGTRAP	Homo sapiens	Q6RW13-2	Validated Y2H	32296183
Intra	MMD	Q15546	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	MMD	Q15546	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	MMD	Q15546	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	MMD	Q15546	C4orf3	Homo sapiens	Q8WVX3-2	Validated Y2H	32296183
Intra	MMD	Q15546	TMEM42	Homo sapiens	Q69YG0	Validated Y2H	32296183
Intra	MMD	Q15546	ATP13A1	Homo sapiens	Q9HD20-3	Validated Y2H	32296183
Intra	MMD	Q15546	TMEM203	Homo sapiens	Q969S6	Validated Y2H	32296183
Intra	MMD	Q15546	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	MMD	Q15546	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	MMD	Q15546	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	MMD	Q15546	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	MMD	Q15546	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	MMD	Q15546	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	MMD	Q15546	OCIAD1	Homo sapiens	Q9NX40	Validated Y2H	32296183
Intra	MMD	Q15546	EMC6	Homo sapiens	Q9BV81	Validated Y2H	32296183
Intra	MMD	Q15546	TMEM60	Homo sapiens	Q9H2L4	Validated Y2H	32296183
Intra	MMD	Q15546	SFXN1	Homo sapiens	Q9H9B4	Validated Y2H	32296183
Intra	MMD	Q15546	YIPF6	Homo sapiens	Q96EC8	Validated Y2H	32296183
Intra	MMD	Q15546	PLEKHO1	Homo sapiens	Q53GL0	Validated Y2H	32296183
Intra	MMD	Q15546	PLEKHO1	Homo sapiens	Q53GL0	Y2H Array	32296183
Intra	MMD	Q15546	PLEKHO1	Homo sapiens	Q53GL0	Y2H Prey Pooling	32296183
Intra	MMD	Q15546	SELENOK	Homo sapiens	Q9Y6D0	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Slate Pneumoconiosis	Schistosis
Spondyloepiphyseal Dysplasia, Maroteaux Type	Spondyloepiphyseal Dysplasia Maroteaux Type Pseudo-Morquio Syndrome Type 2 Sed, Maroteaux Type Brachyolmia Type 2 Pseudo-Morquio Syndrome, Type 2 Spondyloepiphyseal Dysplasia Of Maroteaux Brachyolmia Maroteaux Type SEDM Sed Maroteaux Type Dysplasia, Spondyloepiphyseal, Maroteaux Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS08511	MMD Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08512	MMD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20683	Mmd Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27194	Mmd Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MMD	VGNC	VGNC:31512
Canis familiaris	MMD	VGNC	VGNC:43270
Felis catus	MMD	VGNC	VGNC:68277
Macaca mulatta	MMD	VGNC	VGNC:74885
Mus musculus	MMD	MGD	MGI:1914718
Rattus norvegicus	MMD	RGD	RGD:1592079
Others	MMD	NCBI